Outbreak of OXY-2-producing Klebsiella oxytoca in a renal transplant unit

Journal of Clinical Microbiology

Volumn 46, Issue 6, 2008, Pages 2099-2101

  Zárate, Mariela Soledad ^a,c   Gales, Ana C ^b   Picão, Renata C ^b   Pujol, Gervasio Soler ^a   Lanza, Alejandra ^a   Smayevsky, Jorgelina ^a  

^a CEMIC   (Argentina)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c Guemes 3066 1o Dpto 4   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAMASE; CEFEPIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; IMIPENEM; PIPERACILLIN PLUS TAZOBACTAM;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CLINICAL ARTICLE; ENTEROBACTER INFECTION; ENZYME SYNTHESIS; EPIDEMIC; HOSPITAL DEPARTMENT; HUMAN; KIDNEY GRAFT; KLEBSIELLA OXYTOCA; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PULSED FIELD GEL ELECTROPHORESIS;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; DISEASE OUTBREAKS; ELECTROPHORESIS, GEL, PULSED-FIELD; HOSPITAL UNITS; HUMANS; KIDNEY TRANSPLANTATION; KLEBSIELLA INFECTIONS; KLEBSIELLA OXYTOCA; MICROBIAL SENSITIVITY TESTS; POINT MUTATION; PROMOTER REGIONS (GENETICS);

KLEBSIELLA OXYTOCA;

EID: 45149116494     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.00194-08     Document Type: Article

References (21)

1. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233.
2. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial disk susceptibility tests, 9th ed. Approved standard M2-A9. Clinical End Laboratory Standards Institute, Wayne, PA.
3. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. Approved standard M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
4. Decre, D., B. Burghoffer, V. Gautier, J. C. Petit, and G. Arlet. 2004. Outbreak of multi-resistant Klebsiella oxytoca involving strains with extended-spectrum beta-lactamases and strains with extended-spectrum activity of the chromosomal beta-lactamase. J. Antimicrob. Chemother. 54:881-888.
5. Farmer, J., III. 2003. Enterobacteriaceae: introduction and identification, p. 636-653. In P. R. Murray, E. J. Baron, M. A. Pfaller, J. H. Jorgensen, and R. H. Yolken (ed.), Manual of clinical microbiology, 8th ed. ASM Press, Washington, DC.
6. Fevre, C., M. Jbel, V. Passet, F. X. Weill, P. A. Grimont, and S. Brisse. 2005. Six groups of the OXY β-lactamase evolved over millions of years in Klebsiella oxytoca. Antimicrob. Agents Chemother. 49:3453-3462.
7. Filip, C., G. Fletcher, J. L. Wulf, and C. F. Earhart. 1973. Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate. J. Bacteriol. 115:717-722.
8. Fishman, J. A. 2007. Infection in renal transplant recipients. Semin. Nephrol. 27:445-461.
9. Fournier, B., P. H. Lagrange, and A. Philippon. 1996. β-Lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca. Antimicrob. Agents Chemother. 40:460-463.
10. Fournier, B., A. Gravel, D. C. Hooper, and P. Roy. 1999. Strength and regulation of the different promoters for chromosomal β-lactamase of Klebsiella oxytoca. Antimicrob. Agents Chemother. 43:850-855.
11. OXY-2. Antimicrob. Agents Chemother. 40:454-459.
12. Fournier, B., and P. H. Roy. 1997. Variability of chromosomally encoded β-lactamases from Klebsiella oxytoca. Antimicrob. Agents Chemother. 41:1641-1648.
13. Fournier, B., C. Y. Liu, P. H. Lagrange, R. Krishnamoorthy, and A. Philippon. 1995. Point mutation in the Pribnow box, the molecular basis of β-lactamase overproduction in Klebsiella oxytoca. Antimicrob. Agents Chemother. 39:1365-1368.
14. Hogenauer, C., C. Langner, E. Beubler, I. T. Lippe, R. Schicho, G. Gorkiewicz, R. Krause, N. Gerstgrasser, G. J. Krejs, and T. A. Hinterleitner. 2006. Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitis. N. Engl. J. Med. 355:2418- 2426.
15. Jeong, S. H., W. M. Kim, C. L. Chang, J. M. Kim, K. Lee, Y. Chong, H. Y. Hwang, Y. W. Baek, H. K. Chung, I. G. Woo, and J. Y. Ku. 2001. Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal b-lactamase. J. Hosp. Infect. 48:281-288.
16. Maslow, J. N., M. E. Mulligan, and R. D. Arbeit. 1993. Molecular epidemiology: application of contemporary techniques to the typing of microorganisms. Clin. Infect. Dis. 17:153-162.
17. Podschun, R., and U. Ullmann. 1998. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 11:589-603.
18. Reiss, I., A. Borkhardt, R. Füssle, A. Sziegoleit, and L. Gortner. 2000. Disinfectant contaminated with Klebsiella oxytoca as a source of sepsis in babies. Lancet 356:310.
19. Sardan, Y. C., P. Zarakolu, A. Altun, A.Yildirim, G. Yildirim, G. Hascelik, and O. Uzun. 2004. A cluster of nosocomial Klebsiella oxytoca bloodstream infections in a university hospital. Infect. Control Hosp. Epidemiol. 25:878-882.
20. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
21. Watson, J. T., R. C. Jones, A. M. Siston, J. R. Fernandez, K. Martin, E. Beck, S. Sokalski, B. J. Jensen, M. J. Arduino, A. Srinivasan, and S. I. Gerber. 2005. Outbreak of catheter-associated Klebsiella oxytoca and Enterobacter cloacae bloodstream infections in an oncology chemotherapy center. Arch. Intern. Med. 165:2639-2643.