Chromogranin B regulates calcium signaling, nuclear factor κb activity, and brain natriuretic peptide production in cardiomyocytes

Circulation Research

Volumn 102, Issue 10, 2008, Pages 1230-1238

  Heidrich, Felix M ^a   Zhang, Kun ^a,c   Estrada, Manuel ^b,d   Huang, Yan ^a   Giordano, Frank J ^a   Ehrlich, Barbara E ^a,e  

^a YALE UNIVERSITY   (United States)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF CHILE   (Chile)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain natriuretic peptide; Calcium; Chromogranin B; Inositol 1,4,5 trisphosphate receptor; Nuclear factor NF B

Indexed keywords

ANGIOTENSIN II; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CALCIUM; CALCIUM ION; CHROMOGRANIN B; FLUORESCENT DYE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; LUCIFERASE; TRANSCRIPTION FACTOR NFAT; CHROMOGRANIN B, RAT; NATRIURETIC PEPTIDE PRECURSOR TYPE B, RAT; VASOCONSTRICTOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; UPREGULATION; AGE; ANIMAL; CARDIOMEGALY; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT; SECRETION;

AGE FACTORS; ANGIOTENSIN II; ANIMALS; CALCIUM; CALCIUM SIGNALING; CARDIOMEGALY; CELLS, CULTURED; CHROMOGRANIN B; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RATS; TRANSCRIPTION, GENETIC; VASOCONSTRICTOR AGENTS;

EID: 45149104973     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.166033     Document Type: Article

References (33)

1. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589-600.
2. Swynghedauw B. Phenotypic plasticity of adult myocardium: molecular mechanisms. J Exp Biol. 2006;209:2320-2327.
3. Go LO, Moschella MC, Watras J, Handa KK, Fyfe BS, Marks AR. Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. J Clin Invest. 1995;95:888-894.
4. de Lemos JA, McGuire DK, Drazner MH. B-type natriuretic peptide in cardiovascular disease. Lancet. 2003;362:316-322.
5. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004; 94:110-118.
6. Hall G, Hasday JD, Rogers TB. Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol. 2006;41:580-591.
7. Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994;12:141-179.
8. Helle KB. The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects. Biol Rev Camb Philos Soc. 2004;79:769-794.
9. Yoo SH, Oh YS, Kang MK, Huh YH, So SH, Park HS, Park HY. Localization of three types of the inositol 1,4,5-trisphosphate receptor/Ca(2 +) channel in the secretory granules and coupling with the Ca(2 +) storage proteins chromogranins A and B. J Biol Chem. 2001;276: 45806-45812.
10. Thrower EC, Choe CU, So SH, Jeon SH, Ehrlich BE, Yoo SH. A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel. J Biol Chem. 2003;278:49699-49706.
11. Choe CU, Ehrlich BE. The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamwork. Sci STKE. 2006;2006:re15.
12. Jacob SN, Choe CU, Uhlen P, DeGray B, Yeckel MF, Ehrlich BE. Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons. J Neurosci. 2005;25: 2853-2864.
13. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. Local InsP3-dependent perinuclear Ca2 + signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006;116:675-682.
14. Uhlen P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM. Gain-of-function/Noonan syndrome SHP-2/Ptpn 11 mutants enhance calcium oscillations and impair NFAT signaling. Proc Natl Acad Sci USA. 2006;103:2160-2165.
15. LaPointe MC, Wu G, Garami M, Yang XP, Gardner DG. Tissue-specific expression of the human brain natriuretic peptide gene in cardiac myocytes. Hypertension. 1996;27:715-722.
16. Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Nunez G. An induced proximity model for NF-kappa B activation in the Nodl/RICK and RIP signaling pathways. J Biol Chem. 2000;275: 27823-27831.
17. Huh YH, Jeon SH, Yoo JA, Park SY, Yoo SH. Effects of chromogranin expression on inositol 1,4,5-trisphosphate-induced intracellular Ca2 + mobilization. Biochemistry. 2005;44:6122-6132.
18. Urushitani M, Sik A, Sakurai T, Nukina N, Takahashi R, Julien JP. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci. 2006;9: 108-118.
19. Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D. NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci. 2003;6:1072-1078.
20. Johenning FW, Zochowski M, Conway SJ, Holmes AB, Koulen P, Ehrlich BE. Distinct intracellular calcium transients in neuntes and somata integrate neuronal signals. J Neurosci. 2002;22:5344-5353.
21. Dostal DE, Hunt RA, Kule CE, Bhat GJ, Karoor V, McWhinney CD, Baker KM. Molecular mechanisms of angiotensin II in modulating cardiac function: intracardiac effects and signal transduction pathways. J Mol Cell Cardiol. 1997;29:2893-2902.
22. Sadoshima J, Izumo S. Signal transduction pathways of angiotensin Il-induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res. 1993;73:424-438.
23. Wiese S, Breyer T, Dragu A, Wakili R, Burkard T, Schmidt-Schweda S, Fuchtbauer EM, Dohrmann U, Beyersdorf F, Radicke D, Holubarsch CJ. Gene expression of brain natriuretic peptide in isolated atrial and ventricular human myocardium: influence of angiotensin II and diastolic fiber length. Circulation. 2000;102:3074-3079.
24. Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, Nishino K, Yoshimasa T, Nakao K. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. J Clin Invest. 1995;96:1280-1287.
25. Lokuta AJ, Cooper C, Gaa ST, Wang HE, Rogers TB. Angiotensin II stimulates the release of phospholipid-derived second messengers through multiple receptor subtypes in heart cells. J Biol Chem. 1994;269: 4832-4838.
26. Valdes JA, Hidalgo J, Galaz JL, Puentes N, Silva M, Jaimovich E, Carrasco MA. NF-kappaB activation by depolarization of skeletal muscle cells depends on ryanodine and IP3 receptor-mediated calcium signals. Am J Physiol Cell Physiol. 2007;292:C1960-C1970.
27. Lipp P, Laine M, Tovey SC, Burrell KM, Berridge MJ, Li W, Bootman MD. Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart. Curr Biol. 2000;10:939-942.
28. Mackenzie L, Roderick HL, Proven A, Conway SJ, Bootman MD. Inositol 1,4,5-trisphosphate receptors in the heart. Biol Res. 2004;37: 553-557.
29. Thrower EC, Hagar RE, Ehrlich BE. Regulation of Ins(1,4,5)P3 receptor isoforms by endogenous modulators. Trends Pharmacol Sci. 2001;22: 580-586.
30. Perez PJ, Ramos-Franco J, Fill M, Mignery GA. Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J Biol Chem. 1997;272:23961-23969.
31. Bare DJ, Kettlun CS, Liang M, Bers DM, Mignery GA. Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II. J Biol Chem. 2005;280: 15912-15920.
32. Dolmetsch RE, Lewis RS, Goodnow CC, Healy JL Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature. 1997;386:855-858.
33. Liang F, Gardner DG. Mechanical strain activates BNP gene transcription through a p38/NF-kappaB-dependent mechanism. J Clin Invest. 1999; 104:1603-1612.