3,5,3′-Triiodothyronine thyrotoxicosis due to increased conversion of administered levothyroxine in patients with massive metastatic follicular thyroid carcinoma

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 6, 2008, Pages 2239-2242

  Miyauchi, Akira ^a   Takamura, Yuuki ^a   Ito, Yasuhiro ^a   Miya, Akihiro ^a   Kobayashi, Kaoru ^a   Matsuzuka, Fumio ^a   Amino, Nobuyuki ^a   Toyoda, Nagaoki ^b   Nomura, Emiko ^b   Nishikawa, Mitsushige ^b  

^a KUMA HOSPITAL   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CONTROLLED STUDY; DRUG WITHDRAWAL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; LIOTHYRONINE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METASTASIS; PREVALENCE; PRIORITY JOURNAL; THYROID FOLLICULAR CARCINOMA; THYROID MEDULLARY CARCINOMA; THYROID PAPILLARY CARCINOMA; THYROTOXICOSIS; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

EID: 45149095027     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2282     Document Type: Article

References (13)

1. Grebe SK, Hay ID 1995 Follicular thyroid cancer. Endocrinol Metab Clin North Am 24:761-801
2. Bianco AC, Kim BW 2006 Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest 116:2571-2579
3. 3 in euthyroid humans. J Clin Invest 115:2524-2533
4. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89
5. Salvatore D, Tu H, Harney JW, Larsen PR 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 98:962-968
6. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, Fishman SJ, Larsen PR 2000 Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 343:185-189
7. Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR 2002 A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab 87:4457-4461
8. Takano T, Miyauchi A, Ito Y, Amino N 2006 Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma. Thyroid 16:615-618
9. Kim BW, Daniels GH, Harrison BJ, Price A, Harney JW, Larsen PR, Weetman AP 2003 Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. J Clin Endocrinol Metab 88:594-598
10. Yasuzawa-Amano S, Toyoda N, Maeda A, Kosaki A, Mori Y, Iwasaka T, Nishikawa M 2004 Expression and regulation of type 2 iodothyronine deiodinase in rat aorta media. Endocrinology 145:5638-5645
11. 3 hyperthyroidism with metastatic follicular thyroid carcinoma in substitution therapy]. Nuklearmedizin 35:186-189 (German)
12. Murakami M, Araki O, Hosoi Y, Kamiya Y, Morimura T, Ogiwara T, Mizuma H, Mori M 2001 Expression and regulation of type II iodothyronine deiodinase in human thyroid gland. Endocrinology 142:2961-2967
13. de Souza Meyer EL, Dora JM, Wagner MS, Maia AL 2005 Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. Clin Endocrinol (Oxf) 62:672-678