Synthesis of 8-substituted xanthines via 5,6-diaminouracils: an efficient route to A2A adenosine receptor antagonists

Tetrahedron Letters

Volumn 49, Issue 31, 2008, Pages 4633-4635

  Dong, Ma ^a   Sitkovsky, Mikhail ^a   Kallmerten, Amy E ^a   Jones, Graham B ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

(Bromodimethyl)sulfonium bromide; Adenosine antagonist; Diaminouracils; Xanthine

Indexed keywords

ADENOSINE A2 RECEPTOR ANTAGONIST; ALDEHYDE; ISTRADEFYLLINE; URACIL DERIVATIVE; XANTHINE DERIVATIVE;

ANNULATION REACTION; ARTICLE; BROMINATION; DRUG SYNTHESIS;

EID: 45049085428     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.05.071     Document Type: Article

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14. All new compounds were fully characterized by appropriate spectroscopic and analytical techniques.
15. Ma, D.; Sitkovsky, M.; Jones, G. B., in preparation.
16. We acknowledge financial support for this work from the PRF (33920-AC1) and NIH (RO1GM57123).