Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 5, 2008, Pages

  Grifoni, Samira C ^a   McKey, Susan E ^a   Drummond, Heather A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Acid sensing ion channel; Degenerin proteins; Heat shock protein 70; Interference ribonucleic acid; Ion channel; Vascular smooth muscle cell migration

Indexed keywords

ACID SENSING ION CHANNEL; HEAT SHOCK COGNATE PROTEIN 70; ASIC CHANNEL; DEGENERIN EPITHELIAL SODIUM CHANNELS; EPITHELIAL SODIUM CHANNEL; GLYCEROL; HSPA8 PROTEIN, RAT; MEMBRANE PROTEIN; NERVE PROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB; SMALL INTERFERING RNA; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL LINE; CELL MEMBRANE; CELL MOTION; CYTOPLASM; DRUG EFFECT; GENETICS; METABOLISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION;

ANIMALS; CELL LINE; CELL MEMBRANE; CELL MOVEMENT; CYTOPLASM; EPITHELIAL SODIUM CHANNEL; GLYCEROL; HSC70 HEAT-SHOCK PROTEINS; MEMBRANE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NERVE TISSUE PROTEINS; PLATELET-DERIVED GROWTH FACTOR; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SODIUM CHANNELS; UP-REGULATION;

EID: 44949234777     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01271.2007     Document Type: Article

References (40)

1. Berdiev BK, Xia J, McLean LA, Markert JM, Gillespie GY, Mapstone TB, Naren AP, Jovov B, Bubien JK, Ji HL, Fuller CM, Kirk KL, Benos DJ. Acid-sensing ion channels in malignant gliomas. J Biol Chem 278: 15023-15034, 2003.
2. Bertrand CA, Frizzell RA. The role of regulated CFTR trafficking in epithelial secretion. Am J Physiol Cell Physiol 285: C1-C18, 2003.
3. Brown CR, Hong-Brown LQ, Welch WJ. Correcting temperature- sensitive protein folding defects. J Clin Invest 99: 1432-1444, 1997.
4. Chiang HL, Terlecky SR, Plant CP, Dice JF. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 246: 382-385, 1989.
5. Chifflet S, Hernandez JA, Grasso S. A possible role for membrane depolarization in epithelial wound healing. Am J Physiol Cell Physiol 288: C1420-C1430, 2005.
6. Dormann D, Weijer CJ. Chemotactic cell movement during development. Curr Opin Genet Dev 13: 358-364, 2003.
7. Drummond HA, Furtado MM, Myers S, Grifoni S, Parker KA, Hoover A, Stec DE. ENaC proteins are required for NGF-induced neurite growth. Am J Physiol Cell Physiol 290: C404-C410, 2006.
8. Drummond HA, Gebremedhin D, Harder DR. Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. Hypertension 44: 643-648, 2004.
9. Gannon KP, Galmiche L, Drummond H. ASIC2 protein is required for pressure-induced constriction in mouse middle cerebral artery. FASEB J 21: 587-589, 2007.
10. Gething MJ, Sambrook J. Protein folding in the cell. Nature 355: 33-45, 1992.
11. Goldfarb SB, Kashlan OB, Watkins JN, Suaud L, Yan W, Kleyman TR, Rubenstein RC. Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proc Natl Acad Sci USA 103: 5817-5822, 2006.
12. Grifoni SC, Gannon KP, Stec DE, Drummond HA. ENaC proteins contribute to VSMC migration. Am J Physiol Heart Circ Physiol 291: H3076-H3086, 2006.
13. Grifoni SC, Jernigan NL, Hamilton G, Drummond HA. ASIC proteins regulate smooth muscle cell migration. Microvasc Res 75: 202-210, 2008.
14. Jernigan NL, Drummond HA. Myogenic vasoconstriction in mouse renal interlobar arteries: role of endogenous beta and gamma ENaC. Am J Physiol Renal Physiol 291: F1184-F1191, 2006.
15. Jernigan NL, Drummond HA. Vascular ENaC proteins are required for renal myogenic constriction. Am J Physiol Renal Physiol 289: F891-F901, 2005.
16. Jones GE. Cellular signaling in macrophage migration and chemotaxis. J Leukoc Biol 68: 593-602, 2000.
17. Kashlan OB, Mueller GM, Qamar MZ, Poland PA, Ahner A, Rubenstein RC, Hughey RP, Brodsky JL, Kleyman TR. Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression. J Biol Chem 282: 28149-28156, 2007.
18. Kassis J, Lauffenburger DA, Turner T, Wells A. Tumor invasion as dysregulated cell motility. Semin Cancer Biol 11: 105-117, 2001.
19. Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 82: 735-767, 2002.
20. Libby P, Warner SJ, Friedman GB. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest 81: 487-498, 1988.
21. Majeski AE, Dice JF. Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36: 2435-2444, 2004.
22. Meacham GC, Patterson C, Zhang W, Younger JM, Cyr DM. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol 3: 100-105, 2001.
23. Meltzer RH, Kapoor N, Qadri YJ, Anderson SJ, Fuller CM, Benos DJ. Heteromeric assembly of acid-sensitive ion channel and epithelial sodium channel subunits. J Biol Chem 282: 25548-25559, 2007.
24. Olson TH, Riedl MS, Vulchanova L, Ortiz-Gonzalez XR, Elde R. An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats. Neuroreport 9: 1109-1113, 1998.
25. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004.
26. Pruliere-Escabasse V, Planes C, Fanen P, Escudier E, Coste A, Clerici C. Modulation of ENaC trafficking and function by sodium 4-phenylbutyrate in human nasal epithelial cells. J Biol Chem 23: 34048-34057, 2007.
27. Rensen SS, Doevendans PA, van Eys GJ. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J 15: 100-108, 2007.
28. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809, 1993.
29. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA 71: 1207-1210, 1974.
30. Rubenstein RC, Lyons BM. Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation. Am J Physiol Lung Cell Mol Physiol 281: L43-L51, 2001.
31. Rubenstein RC, Zeitlin PL. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol 278: C259-C267, 2000.
32. Rutherford C, Martin W, Salame M, Carrier M, Anggard E, Ferns G. Substantial inhibition of neo-intimal response to balloon injury in the rat carotid artery using a combination of antibodies to platelet-derived growth factor-BB and basic fibroblast growth factor. Atherosclerosis 130: 45-51, 1997.
33. Sato S, Ward CL, Krouse ME, Wine JJ, Kopito RR. Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J Biol Chem 271: 635-638, 1996.
34. Schwab A. Function and spatial distribution of ion channels and transporters in cell migration. Am J Physiol Renal Physiol 280: F739-F747, 2001.
35. Seppa H, Grotendorst G, Seppa S, Schiffmann E, Martin GR. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol 92: 584-588, 1982.
36. Skach WR. Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator. Kidney Int 57: 825-831, 2000.
37. Tamarappoo BK, Yang B, Verkman AS. Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus. J Biol Chem 274: 34825-34831, 1999.
38. Vila-Carriles WH, Kovacs GG, Jovov B, Zhou ZH, Pahwa AK, Colby G, Esimai O, Gillespie GY, Mapstone TB, Markert JM, Fuller CM, Bubien JK, Benos DJ. Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. J Biol Chem 281: 19220-19232, 2006.
39. Vila-Carriles WH, Zhou ZH, Bubien JK, Fuller CM, Benos DJ. Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells. J Biol Chem 282: 34381-34391, 2007.
40. Zeitlin PL, Diener-West M, Rubenstein RC, Boyle MP, Lee CK, Brass-Ernst L. Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate. Mol Ther 6: 119-126, 2002.