Oestrogen and benign prostatic hyperplasia: Effects on stromal cell proliferation and local formation from androgen

Journal of Endocrinology

Volumn 197, Issue 3, 2008, Pages 483-491

  Ho, Clement K M ^a   Nanda, Jyoti ^a   Chapman, Karen E ^b   Habib, Fouad K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; AROMATASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; MESSENGER RNA;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; ESTROGEN ACTIVITY; GENE EXPRESSION; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; WESTERN BLOTTING;

ANDROGENS; AROMATASE; CELL PROLIFERATION; CELLS, CULTURED; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; MALE; PROSTATE; PROSTATIC HYPERPLASIA; RNA, MESSENGER; STROMAL CELLS;

EID: 44949229146     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-07-0470     Document Type: Article

References (43)

1. Azzouzi AR, Cochand-Priollet B, Mangin P, Fournier G, Berthon P, Latil A & Cussenot O 2002 Impact of constitutional genetic variation in androgen/ oestrogen-regulating genes on age-related changes in human prostate. European Journal of Endocrinology 147 479-484.
2. Bayne CW, Donnelly F, Chapman K, Bollina P, Buck C & Habib F 1998 A novel coculture model for benign prostatic hyperplasia expressing both isoforms of5 alpha-reductase. Journal of Clinical Endocrinology and Metabolism 83 206-213.
3. Berthois Y, Katzenellenbogen JA & Katzenellenbogen BS 1986 Phenol red in issue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. PNAS 83 2496-2500.
4. BonkhoffH, Fixemer T, Hunsicker I & Remberger K 1999 Estrogen receptor expression in prostate cancer and premalignant prostatic lesions. American Journal of Pathology 155 641-647.
5. Boyan BD, Sylvia VL, Frambach T, Lohmann CH, Died J, Dean DD & Schwartz Z 2003 Estrogen-dependent rapid activation of protein kinase C in estrogen receptor-positive MCF-7 breast cancer cells and estrogen receptor-negative HCC38 cells is membrane-mediated and inhibited by Tamoxifen. Endocrinology 144 1812-1824.
6. Brodie AM, Son C, King DA, Meyer KM & Inkster SE 1989 Lack of evidence for aromatase in human prostatic tissues: effects of 4-hydroxyandrostene-dione and other inhibitors on androgen metabolism. Cancer Research 49 6551-6555.
7. Collins AT, Zhiming B, Gilmore K & Neal DE 1994 Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: oestrogen regulation of the androgen receptor. Journal of Endocrinology 143 269-277.
8. Daehlin L, Bergh A & Damber JE 1987 Direct effects of oestradiol on growth and morphology of the Dunning R3327H prostatic carcinoma. Urological Research 15 169-172.
9. DeKlerk DP, Coffey DS, Ewing LL, McDermott IR, Reiner WG, Robinson CH, Scott WW, Strandberg JD, Talalay P, Walsh PC et al. 1979 Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. Journal of Clinical Investigation 64 842-849.
10. Ehara H, Koji T, Deguchi T, Yoshii A, Nakano M, Nakane PK & Kawada Y 1995 Expression of estrogen receptor in diseased human prostate assessed by non-radioactive in situ hybridization and immunohistochemistry. Prostate 27 304-313.
11. Gray A, Feldman HA, McKinlayJB & Longcope C 1991 Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. Journal of Clinical Endocrinology and Metabolism 73 1016-1025.
12. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y & Shine 1986 Sequence and expression of human estrogen receptor complementary DNA. Science 231 1150-1154.
13. Habib FK, Ross M, Ho CK, Lyons V & Chapman K 2005 Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. International Journal of Cancer 114 190-194.
14. Harman SM, Metter EJ, Tobin JD, Pearson J & Blackman MR 2001 Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. Journal of Clinical Endocrinology and Metabolism 86 724-731.
15. Hiramatsu M, Maehara L, Ozaki M, Harada N, Orikasa S & Sasano H 1997 Arorratase in hyperplasia and carcinoma ofthe human prostate. Prostate 31 118-124.
16. Ho SM 2004 Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates. Journal of Cellular Biochemistry 91 491-503.
17. Jin B, Turner L, Walters WA & Handelsman DJ 1996 The effects of chronic high dose androgen or estrogen treatment on the human prostate [corrected]. Journal of Clinical Endocrinology and Metabolism 81 4290-4295.
18. Katzenellenbogen BS, Montano MM, Ediger TR, Sun J, Ekena K, Lazennec G, Martini PG, McInerney EM, Delage-Mourroux R, Weis K et al. 2000 Estrogen receptors: selective ligands, partners, and distinctive pharmacology. Recent Progress in Hormone Research 55 163-193 (discussion 194-165).
19. King KJ, Nicholson HD & Assinder SJ 2006 Effect of increasing ratio of estrogen: androgen on proliferation of normal human prostate stromal and epithelial cells, and the malignant cell line LNCaP. Prostate 66 105-114.
20. Kozak I, Bartsch W, Krieg M & Voigt KD 1982 Nuclei of stroma: site of highest estrogen concentration in human benign prostaric hyperplasia. Prostate 3 433-438.
21. Lau KM, LaSpina M, Long J & Ho SM 2000 Expression of estrogen receptor ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Research 60 3175-3182.
22. Levine AC, Ren M, Huber GK & Kirschenbaum A 1992 The effect of androgen, estrogen, and growth factors on the proliferation of cultured fibroblasts derived from human fetal and adult prostates. Endocrinology 130 2413-2419.
23. MacGregor JI & Jordan VC 1998 Basic guide to the mechanisms of antiestrogen action. Pharmacological Reviews 50 151-196.
24. Maghni K, Nicolescu OM & Martin JG 1999 Suitability of cell metabolic colorimetric assays for assessment of CD4+T cell proliferation: comparison to 5-bromo-2-deoxyuridine (BTdU) ELISA. Journal of Immunological Methods 223 185-194.
25. Matzkin H & Soloway MS 1992 Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate 21 309-314.
26. McPherson SJ, Ellem SJ, Simpson ER, Patchev V, Fritzemeier KH & Risbridger GP 2007 Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. Endocrinology 148 566-574.
27. Moore JT, McKee DD, Slentz-Kesler K, Moore LB, Jones SA, Horne EL, Su JL, Kliewer SA, Lehmann JM & Willson TM 1998 Cloning and characterization of human estrogen receptor beta isoforms. Biochemical and Biophysical Research Communications 247 75-78.
28. Mosselman S, Polmanj & Dijkema R 1996 ERO: identification and characterization ofa novel human estrogen receptor. FEBS Letters 392 49-53.
29. Pasquali D, Rossi V, Esposito D, Abbondanza C, Puca GA, Bellastella A & Sinisi AA 2001a Loss ofestrogen receptor beta expression in malignant human prostate cells in primary cultures and in prostate cancer tissues. Journal of Clinical Endocrinology and Metabolism 86 2051-2055.
30. Pasquali D, Staibano S, Prezioso D, Franco R, Esposito D, Notaro A, De Rosa G, Bellastella A & Sinisi AA 2001b Estrogen receptor beta expression in human prostate tissue. Molecular and Cellular Endocrinology 178 47-50.
31. Roberts RO, Bergstralh EJ, Farmer SA, Jacobson DJ, Hebbring SJ, Cunningham JM, Thibodeau SN, Lieber MM & Jacobsen SJ 2006 Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia. Prostate 66 392-404.
32. Royuela M, de Miguel NIP, Bethencourt FR, Sanchez-Chapado M, Fraile B, Arenas MI & Parnagua R 2001 Estrogen receptors alpha and beta in the normal, hyperplastic and carcinomatous human prostate. Journal of Endocrinology 168 447-454.
33. Saunders PT, Millar MR, Williams K, Macpherson S, Harkiss D, Anderson RA, Orr B, Groome, NP, Scobie G & Fraser HM 2000 Differential expression of estrogen receptor-alpha and -beta and androgen receptor in he ovaries ofmarmosets and humans. Biology of Reproduction 63 1098-1105.
34. Schweikert HU 1979 Conversion of androstenedione to estrone in human fibroblasts cultured from prostate, gerrital and nongenital skin. Hormone and Metabolic Research 11 635-640.
35. Simpson ER, Mahendroo MS, Means GD, Eilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD et al. 1994 Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocrine Reviews 15 342-355.
36. Stone NN, Fair WR & Fishman J 1986 Estrogen formation in human prostatic tissue from patients with and without benign prostatic hyperplasia. Prostate 9 311-318.
37. Sugimura Y, Cunha GR, Yonemura CU & Kawamura J 1988 Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia of the developing human prostate. Human Pathology 19 133-139.
38. Tsugaya M, Habib FK, Chisholm GD, Ross M, Tozawa K, Hayashi Y, Kohri K & Tanaka S 1996 Testosterone metabolism in primary cultures of epithelial cells and stroma from benign prostatic hyperplasia. Urological Research 24 265-271.
39. Tsurusaki T, Aoki D, Kanetake H, Inoue S, Muramatsu M, Hishikawa Y & Koji T 2003 Zone-dependent expression of estrogen receptors alpha and beta in human benign prosratic hyperplasia. Journal of Clinical Endocrinology and Metabolism 88 1333-1340.
40. Uson AC, Paez AB & Uson-Jaeger J 1991 The natural history and course of untreated benign prostatic hyperphsia. European Urology 20 (Suppl 1) 22-26.
41. Verhamme KM, Dieleman JP, Bleumink GS, van der Lei J, Sturkenboom MC, Artibani W, Begaud B, Berges R, Borkowski A, Chappel CR et al. 2002 Incidence and prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in primary care-the Triumph project. European Urology 42 323-328.
42. Vermeulen A, Kaufman JM, Goemaere S & van Pottelberg 1 2002 Estradiol in elderly men. Aging Male 5 98-102.
43. Walsh PC & Wilson JD 1976 The induction ofprostaric hypertrophy in the dog with androstenediol. Journal of Clinical Investigation 57 1093-1097.