Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats

Veterinary Journal

Volumn 177, Issue 2, 2008, Pages 297-299

  Capece, Bettencourt P S ^a,b   Castells, Gloria ^b   Godoy, Carlo ^b   Arboix, Margarita ^b   Cristòfol, Carles ^b  

^a EDUARDO MONDLANE UNIVERSITY   (Mozambique)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Albendazole sulfoxide; Enantiomers; Enantioselectivity; Pharmacokinetics; Rats

Indexed keywords

ALBENDAZOLE 2 AMINOSULFONE; ALBENDAZOLE SULFONE; ALBENDAZOLE SULFOXIDE; DRUG METABOLITE; OXIBENDAZOLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHIRALITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG FORMULATION; DRUG METABOLISM; DRUG SAFETY; DRUG URINE LEVEL; ENANTIOMER; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PLASMA CONCENTRATION-TIME CURVE; RACEMIC MIXTURE; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOMERISM; RATS;

RATTUS;

EID: 44949223357     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.04.011     Document Type: Article

References (13)

1. Berrozpe, J.D., Lanas, J.M., Pla-Delfina, J.M., 1997. Biofarmacia y farmacocinética, vol. 1, Editorial Síntesis S.A., Madrid. pp. 167-200.
2. Bolás-Fernández F., Rama-Iñiguez S., and Torrado J.J. Ex vivo anthelmintic activity of albendazole sulfoxide enantiomers. Journal of Parasitology 90 (2004) 407-409
3. Capece B.P.S., Castells G., Perez F., Arboix M., and Cristofol C. Pharmacokinetic behaviour of albendazole sulfoxide enantiomers in male and female sheep. Veterinary Research Communications 24 (2000) 339-348
4. Capece B.P.S., Navarro M., Arcalis T., Castells G., Toribio L., Pérez F., Carretero A., Ruberte J., Arboix M., and Cristòfol C. Albendazole sulfoxide enantiomers in pregnant rats. Embryo concentrations and developmental toxicity. The Veterinary Journal 165 (2003) 266-275
5. Cristòfol C., Virkel G., Alvarez L., Sanchez S., Arboix M., and Lanusse C. Albendazole sulfoxide enantiomeric ratios in plasma and target tissues after intravenous administration of ricobendazole to cattle. Journal of Veterinary Pharmacology and Therapeutics 24 (2001) 117-124
6. Delatour P., Benoit E., Caude M., and Tambute A. Species differences in the generation of the chiral sulfoxide metabolite of albendazole in sheep and rats. Chirality 2 (1990) 156-160
7. Farrier D.S. PK Solution (ver 2.0.2): a non-compartmental pharmacokinetic data analysis program (1997), Summit Research, Ashland, Ohio
8. Hennessy D.R., Steel J.W., Lacey E., Eagleson G.K., and Prichard R.K. The disposition of albendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics 12 (1989) 421-429
9. Lanchote V.L., Takayanagui O.M., and Mateus F.H. Enantioselective renal excretion of albendazole metabolites in patients with neurocysticercosis. Chirality 16 (2004) 520-525
10. Merino G., Molina A.J., García J.L., Pulido M.M., Prieto J.G., and Álvarez A.I. Intestinal elimination of albendazole sulfoxide: pharmacokinetic effects of inhibitors. International Journal of Pharmaceutics 263 (2003) 123-132
11. Sanchez S., Alvarez L.I., and Lanusse C.E. Fasting-induced changes to the pharmacokinetic behaviour of albendazole and its metabolites in calves. Journal of Veterinary Pharmacology and Therapeutics 20 (1997) 38-47
12. Teruel M.T., Felipe A.E., Solana H.D., Sallovitz J.M., and Lanusse C.E. Placental and fetal toxicity of albendazole sulfoxide in Wistar rats. Veterinary and Human Toxicology 45 (2003) 131-136
13. Toribio L., Nozal M.J., Bernal E.M., and Nieto E.M. Use of supercritical fluid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers. Journal of Chromatography A 1011 (2003) 155-161