Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl- 4-substituted-1-pyrrolidinyl group as a C-10 substituent

Journal of Medicinal Chemistry

Volumn 51, Issue 11, 2008, Pages 3238-3249

  Asahina, Yoshikazu ^a   Takei, Masaya ^a   Kimura, Tetsuya ^a   Fukuda, Yasumichi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINAFLOXACIN; FENBUFEN; GATIFLOXACIN; GEMIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; NORFLOXACIN; PYRIDO[1,2,3 DE][1,4]BENZOXAZINE 6 CARBOXYLIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; IC 50; KLEBSIELLA PNEUMONIAE; MALE; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; MOUSE; NEUROTOXICITY; NONHUMAN; PHOTOTOXICITY; PSEUDOMONAS AERUGINOSA; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZOXAZINES; DRUG RESISTANCE, BACTERIAL; FLUOROQUINOLONES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MALE; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; PYRROLIDINES; QUINOLONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44949217478     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701428b     Document Type: Article

References (38)

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