Chiral DNA Gyrase Inhibitors. 2. Asymmetric Synthesis and Biological Activity of the Enantiomers of 9-Fluoro-3-methyl-10-(4-methyl-l-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[l,2,3-de]-l,4-benzoxazine-6-carboxylic Acid (Ofloxacin)

Journal of Medicinal Chemistry

Volumn 30, Issue 12, 1987, Pages 2283-2286

  Mitscher, Lester A ^a   Sharma, Padam N ^a   Chu, Daniel T W ^b   Shen, Linus L ^b   Pernet, Andre G ^b  

^a UNIVERSITY OF KANSAS   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); NORFLOXACIN; OFLOXACIN;

ANIMAL CELL; BACTERIUM; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; DNA TOPOISOMERASES, TYPE II; OFLOXACIN; OXAZINES; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023628552     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00395a017     Document Type: Article

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