Endothelial dysfunction in growth hormone deficiency

Journal of Pediatric Endocrinology and Metabolism

Volumn 21, Issue 4, 2008, Pages 319-321

  Lanes, Roberto ^a,b  

^a Hospital de Clinicas Caracas   (Venezuela)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; GROWTH HORMONE; HUMAN GROWTH HORMONE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; NITRIC OXIDE; SOMATOMEDIN C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ATHEROGENESIS; BLOOD FLOW; CELL ACTIVATION; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONAL REGULATION; HORMONE SUBSTITUTION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LONG TERM CARE; LOW DRUG DOSE; NOTE; POSTPRANDIAL STATE; PROTEIN FUNCTION; THROMBOCYTE ACTIVATION; THROMBOSIS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 44949175164     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2008.21.4.319     Document Type: Note

References (13)

1. Twickler TB, Dallinga-Thie GM, Visseren FLJ, De Vries WR, Erkelens DW, Kopperschaar HPF. Induction of postprandial inflammatory response in adult onset growth hormone deficiency is related to plasma remnant-like particle-cholesterol concentration. J Clin Endocrinol Metab 2003; 88: 1228-1233.
2. Leonsson M, Hulthe J, Johannsson G, Wiklund O, Wikstrandt J, Bengtsson BA, Oscarsson J. Increased interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness. Clin Endocrinol 2003; 59: 242-250.
3. Lanes R, Paoli M, Carrillo E, Villaroel O, Palacios A. Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency. Relation to postprandial dyslipidemia. J Pediatr 2004; 145: 659-663.
4. Elhadd TA, Abdu TA, Oxtoby J, Kennedy G, McLaren M, Neary R, Belch JJF, Clayton RN. Biochemical and biophysical markers of endothelial dysfunction in adults with hypopituitarism and severe GH deficiency. J Clin Endocrinol Metab 2001; 86: 4223-4232.
5. Kvasnicka J, Marek J, Kvasnicka T, Weiss V, Markova M, Stepan J, Umlaufova A. Increase of adhesion molecules, fibrinogen, type-1 plasminogen activator and orosomucoid in growth hormone (GH) deficient adults and their modulation by recombinant GH replacement. Clin Endocrinol 2000; 52: 543-548.
6. Lanes R, Marcano H, Villaroel O, Moriilo E, Gunczler P, Paoli M, Perez M, Maulino N, Palacios A. Circulating levels of highly sensitive C-reactive protein and soluble markers of vascular cell activation in growth hormone deficiency. Horm Res 2008; in press.
7. Borson-Chazot F, Serusclat A, Kalfallah Y, Ducottet X, Sassolas G, Bernard S, Labrousse F, Pastene J, Sassolas A, Roux Y, Berthezene F. Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency. J Clin Endocrinol Metab 1999; 84: 1329-1333
8. Colao A, Di Somma C, Rota F, Di Maoio, Salerno M, Klain A, Spiezia S, Lombardi G. Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents: a prospective study after GH withdrawal and restarting GH replacement. J Clin Endocrinol Metab 2005; 90: 2659-2665.
9. Lanes R, Soros A, Flores K, Gunczler P, Carrillo E, Bandel J. Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue and left ventricular mass and function in growth hormone deficient adolescents. J Clin Endocrinol Metab 2005; 90: 3978-3982.
10. Kostro JS, Tolwinska J, Urban M, Gardziejczyk M, Glowinska B. Cardiac mass and function, carotid artery intima media thickness, homocysteine and lipoprotein levels in children and adolescents with growth hormone deficiency. J Pediatr Endocrinol Metab 2004; 17: 1405-1413.
11. Smith JC, Evans LM, Wilkinson I, Goodfellow J, Cockcroft JR, Scanlon MF, Davies JS. Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults; a randomized, double-blind, palcebo-controlled study. Clin Endocrinol 2002; 5: 493-501.
12. Pfeifer M, Verhovec R, Zizek B, Prezelj J, Poredos P, Clayton RN. Growth hormone (GH) treatment reverses early atherosclerotic changes in GH-deficient adults. J Clin Endocrinol Metab 1999; 84: 453-457.
13. Hoffman RP. Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency. J Pediatr Endocrinol Metab 2008; 21: 323-328.