Independent measures of insulin secretion and insulin sensitivity during the same test: The glucagon-insulin tolerance test

Journal of Internal Medicine

Volumn 264, Issue 1, 2008, Pages 62-71

  Dorkhan, M ^a   Tripathy, D ^b   Malm, G ^c   Asgharian, H ^a   Tuomi, T ^d,e   Groop, L ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c Health Care Centre Eden   (Sweden)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Disposition index; Euglycaemic clamp; Insulin secretion; Insulin sensitivity; Insulin tolerance test; Type 2 diabetes

Indexed keywords

C PEPTIDE; INSULIN;

ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REPRODUCIBILITY; VALIDATION PROCESS;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HORMONES; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS;

EID: 44949174021     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2008.01921.x     Document Type: Article

References (27)

1. Beck-Nielsen H, Groop LC. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus. J Clin Invest 1994 94 : 1714 21.
2. Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest 2000 106 : 329 33.
3. Eriksson J, Franssila-Kallunki A, Ekstrand A et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1989 321 : 337 43.
4. Tripathy D, Carlsson AL, Lehto M, Isomaa B, Tuomi T, Groop L. Insulin secretion and insulin sensitivity in diabetic subgroups: studies in the prediabetic and diabetic state. Diabetologia 2000 43 : 1476 83.
5. Kahn SE, Prigeon RL, McCulloch DK et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993 42 : 1663 72.
6. Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol 1979 236 : E667 77.
7. Korytkowski MT, Berga SL, Horwitz MJ. Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose. Metabolism 1995 44 : 1121 5.
8. Saad MF, Anderson RL, Laws A et al. A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study. Diabetes 1994 43 : 1114 21.
9. Saad MF, Steil GM, Riad-Gabriel M et al. Method of insulin administration has no effect on insulin sensitivity estimates from the insulin-modified minimal model protocol. Diabetes 1997 46 : 2044 8.
10. Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 2000 43 : 1507 11.
11. Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 2002 51 (Suppl. 1 S212 20.
12. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 9.
13. Ferrara CM, Goldberg AP. Limited value of the homeostasis model assessment to predict insulin resistance in older men with impaired glucose tolerance. Diabetes Care 2001 24 : 245 9.
14. Groop L, Forsblom C, Lehtovirta M et al. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 1996 45 : 1585 93.
15. Tripathy D, Wessman Y, Gullstrom M, Tuomi T, Groop L. Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp. Diabetes Care 2003 26 : 1395 401.
16. Scheen AJ, Castillo MJ, Lefebvre PJ. Glucagon-induced plasma C-peptide response in diabetic patients. Influence of body weight and relationship to insulin requirement. Diabetes Metab 1996 22 : 455 8.
17. Scheen AJ, Castillo MJ, Lefebvre PJ. Assessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications. Diabetes Metab 1996 22 : 397 406.
18. Akinmokun A, Selby PL, Ramaiya K, Alberti KG. The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp. Diabet Med 1992 9 : 432 7.
19. Zimmet PZ. Diabetes epidemiology as a tool to trigger diabetes research and care. Diabetologia 1999 42 : 499 518.
20. Segal KR, Van Loan M, Fitzgerald PI, Hodgdon JA, Van Itallie TB. Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr 1988 47 : 7 14.
21. Utzschneider KM, Prigeon RL, Carr DB et al. Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses. Diabetes Care 2006 29 : 356 62.
22. Hirst S, Phillips DI, Vines SK, Clark PM, Hales CN. Reproducibility of the short insulin tolerance test. Diabet Med 1993 10 : 839 42.
23. Hermans MP, Levy JC, Morris RJ, Turner RC. Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes. Diabetologia 1999 42 : 678 87.
24. Ahren B, Nobin A, Schersten B. Insulin and C-peptide secretory responses to glucagon in man: studies on the dose-response relationships. Acta Med Scand 1987 221 : 185 90.
25. Hermans MP, Levy JC, Morris RJ, Turner RC. Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes. Diabetes 1999 48 : 1779 86.
26. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001 50 (Suppl. 1 S154 9.
27. Gerich J, Cryer P, Rizza R. Hormonal mechanisms in acute glucose counterregulation: the relative roles of glucagon, epinephrine, norepinephrine, growth hormone, and cortisol. Metabolism 1980 29 : 1164 75.