Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: Effect of metal cis/trans isomerism and DNA threading groups

Journal of Medicinal Chemistry

Volumn 51, Issue 11, 2008, Pages 3069-3072

  Choudhury, Jayati Roy ^a   Guddneppanavar, Rajsekhar ^a   Saluta, Gilda ^b   Kucera, Gregory L ^a,b   Bierbach, Ulrich ^a,b  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; INTERCALATING AGENT; PLATINUM COMPLEX;

ARTICLE; CELL STRAIN HL 60; CIRCULAR DICHROISM; CIS TRANS ISOMERISM; DNA CONFORMATION; DNA DETERMINATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ACRIDINES; ANTINEOPLASTIC AGENTS; CHELATING AGENTS; CIRCULAR DICHROISM; DNA; HL-60 CELLS; HUMANS; INTERCALATING AGENTS; NUCLEIC ACID CONFORMATION; PLATINUM; POLYDEOXYRIBONUCLEOTIDES; SOLUBILITY; STEREOISOMERISM; WATER;

EID: 44949122534     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8003569     Document Type: Article

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