Mechanisms responsible for the vascular effect of aqueous Trigonella foenum-graecum leaf extract in diabetic rats

Indian Journal of Pharmacology

Volumn 40, Issue 2, 2008, Pages 59-63

  Mahdavi, Mohammad Reza ^a   Roghani, Mehrdad ^a   Baluchnejadmojarad, Tourandokht ^b  

^a SHAHED UNIVERSITY   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aorta; Diabetes mellitus; Rat; Streptozotocin; Trigonella foenum graecum

Indexed keywords

GLUCOSE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NORADRENALIN; POTASSIUM CHLORIDE; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN SYNTHASE; STREPTOZOCIN; TRIGONELLA FOENUM GRAECUM EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; AQUEOUS SOLUTION; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; FENUGREEK; MALE; NONHUMAN; RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

EID: 44949083405     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.41039     Document Type: Article

References (17)

1. Jeffcoate SL. Diabetes control and complications: The role of glycated haemoglobin, 25 years on. Diabetes Med 2004;21:657-65.
2. Watkins LO. Epidemiology and burden of cardiovascular disease. Clin Cardiol 2004;27:32-6.
3. Al-Habori M, Raman A, Lawrence MJ, Skett P. In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. Int J Exp Diabetes Res 2001;2:91-9.
4. Alarcon-Aguilara FJ, Roman-Ramos R, Perez-Gutierrez S, Agui-lar-Contreras A, Contreras-Weber CC, Flores-Saenz JL. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10.
5. Abdel-Barry JA, Abdel-Hassan IA, Al-Hakiem MH. Hypoglycemic and antihyperglycemic effects of Trigonella foe-num-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 1997;58:149-55.
6. Vaez-Mahdavi MR, Roghani M, Baluchnejadmojarad T, Roghani-Dehkordi F. Endothelium-dependent attenuating effect of Trigonella foenum-graecum on the contractile vascular reactivity of diabetic rats. Iran Biomed J 2005;9:129-33.
7. Macleod KM, McNeill JH. Alpha adrenoceptor mediated responses in aorta from three month streptozotocin diabetic rats. Proc West Pharmacol Soc 1982;25:245-7.
8. Roghani Dehkordi F, Roghani M, Baluchnejadmojarad T. The effect of quinapril on the aortic contractile response of streptozotocin-diabetic rats. Iran Biomed J 2003;7:173-7.
9. Abebe W, Harris KH, Macleod KM. Enhanced contractile responses of arteries from diabetic rats to 1-adrenoceptor stimulation in the absence and presence of extracellular calcium. J Cardiovas Pharmacol 1990;16:239-48.
10. Ozcelikay AT, Pekiner C, Ari N, Ozturk Y, Ozuari A, Altan VM. The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats. Diabetologia 1994;37:572-78.
11. Karasu C, Altan VM. The role of endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: Effects of insulin treatment. Gen Pharmacol 1993;24:743-55.
12. Chang KC, Chung SY, Chong WS, Suh JS, Kim SH, Noh, H.K, et al. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 1993;266:992-1000.
13. Hopfner RL, Misurski D, Wilson TW, McNeill JR, Gopalakrishnan V. Insulin and vanadate restore decreased plasma endothelin concentrations and exaggerated vascular responses to normal in the streptozotocin diabetic rat. Diabetologia 1998;41:1233-40.
14. Bonnefont-Rousselot D, Beaudeux JL, Therond P, Peynet J, Legrand A, Delattre J. Diabetes mellitus, oxidative stress and advanced glycation endproducts. Ann Pharm Fr 2004;62:147-57.
15. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1992;40:405-12.
16. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991;87:432-8.
17. Mombouli JV, Vanhoutte PM. Endothelial dysfunction: From physiology to therapy. J Mol Cell Cardiol 1999;31:61-74.