Prolactin levels during long-term risperidone treatment in children and adolescents: A cross-sectional study

German Journal of Psychiatry

Volumn 11, Issue 2, 2008, Pages 45-50

  Buhagiar, Kurt ^a,b   Cassar, Joseph R ^a  

^a Mount Carmel Hospital   (Malta)

^b St Ita's Hospital   (Ireland)

Author keywords

Adolescents; Antipsychotic drugs; Children; Hyperprolactinaemia; Prolactin; Risperidone

Indexed keywords

PROLACTIN; RISPERIDONE;

ADOLESCENT; AGE; ARTICLE; AUTISM; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISRUPTIVE BEHAVIOR; DRUG DOSE COMPARISON; FEMALE; HUMAN; HYPERPROLACTINEMIA; MALE; MALTA; MEDICAL RECORD REVIEW; MEDICAL RESEARCH; MENTAL DEFICIENCY; PRESCRIPTION; PROLACTIN BLOOD LEVEL; PSYCHOSIS; SCHOOL CHILD; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; TREATMENT DURATION;

EID: 44849139151     PISSN: None     EISSN: 14331055     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Alfaro, C. L., Wudarsky, M., Nicolson, R., et al (2002) Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine. J Chid Adolesc Psychopharm 12, 83-91.
2. Aman, M. G., De Smedt, G., Derivan, A., et al (2002) Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligence. Am J Psychiatry 159, 1337-1346.
3. Aman, M., Buitelaar, J., De Smedt, G., et al (2005) Pharmacotherapy of disruptive behavior on a standardized rating scale: pooled analysis of risperidone - Effects in children with subaverage IQ. J Child Adolesc Psychopharm 15, 220-232.
4. Armenteros, J. L., Whitaker, A. H., Welikson, M., et al (1997) Risperidone in adolescents with schizophrenia: an open pilot study. J Am Acad Child Adolesc Psychiatry 36, 694-700.
5. Biederman, J., Mick, E., Wozniak, J., et al (2002) An open-label trial of Risperidone in children and adolescents with bipolar disorder. J Child Adolesc Psychopharm 15, 311-317.
6. Bruun, R. D. & Budman, C. L. (1996) Risperidone as a treatment for Tourette's syndrome. J Clin Psychiatry 57, 29-31.
7. Cesena, M., Gonzalez-Heydrich, J., Szigethy, E., et al (2002) A case series of eight aggressive young children treated with risperidone. J Child Adolesc Psychopharm 12, 337-345.
8. Cohen, L. G. & Biederman, J. (2001) Treatment of risperidone-induced hypeprolactinaemia with a dopamine agonist in children. J Child Adolesc Psychopharm 11, 435-440.
9. Colao, A., Loche, S., Cappa, M., et al (1998) Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab 83, 2777-2780.
10. Croonbhergs, J., Fegert, J. M., Findling R.L., et al (2005) Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients. J Am Acad Child Adolesc Psychiatry 44, 64-72.
11. Dion, Y., Annable, L., Sandor, P., et al (2002) risperidone in the treatment of Tourette syndrome: a double-blind, placebo-controlled trial. J Clin Psychopharmacol 22, 31-399.
12. Findling, R. L., Kusumakar, V., Danema, D., et al (2003) Prolactin levels during long-term risperidone treatment in children and adolescents. J Clin Psychiatry 64, 1362-1369.
13. Findling, R. L., Aman, M.G., Eerdekens, M., et al (2004) Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQ. Am J Psychiatry 161, 677-684.
14. Fitzgerald, K. D., Stewart, C. M., Tawile V., et al (1999) Risperidone augmentation of serotonin reuptake inhibitor treatment of paediatric obsessive compulsive disorder. J Child Adolesc Psychopharm 9, 115-123.
15. Green, B. (2000) Focus on risperidone. Curr Med Res Opin, 16, 57-65.
16. Halbreich, U. & Kahn, L. S. (2003) Hyperprolactinaemia and schizophrenia: mechanisms and clinical aspects. J Psychiatr Prac, 9, 344-353.
17. Hardan, A., Johnson, K., Johnson, C., et al (1996) Case Study: Risperidone treatment of children and adolescents with developmental disorders. J Am Acad Child Adolesc Psychiatry 35, 1551-1556.
18. Hellings, J. A., Zarcone, J. R., Valdovinos, M. G., et al (2005) Risperidone-induced prolactin elevation in a prospective Study of children, 1 Adolescents, and adults with mental retardation and pervasive developmental disorders. J Child Adolesc Psychopharm 15, 885-892.
19. Kinon, B. J., Gilmore, J. A., Liu, H., et al (2003) Prevalence of hyperprolactinaemia in schizophrenic patients treated with conventional antipsychotic medications or risperidone. Psychoneuroendocrinol, 28, (suppl. 2), 55-68.
20. Kleinbetg, D. L., Davis, J. L., De Coster, R., et al (1999) Prolactin levels and adverse events in patients treated with risperidone. J Clin Psychopharmacol 19, 57-61.
21. Malone, R. P., Maishn, G., Choudhury, M. S., et al (2002) risperidone Treatment in children and adolescents with autism: short- and long-term safety and effectiveness. J Am Acad Child Adolesc Psychiatry 41, 140-147.
22. Masi, G., Cosenza, A., & Mucci, M. (2001) Prolactin levels in young children with pervasive developmental disorders during risperidone treatment. J Child Adolesc Psychopharm 11, 389-394.
23. McDougle, C. J., Holmes, J. P., Carlson, D. C., et al (1998) A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Arch Gen Psychiatry 55, 633-641.
24. Nicolson, R., Awad, G., & Sloman L. (1998) An open trial of risperidone in young autistic children. J Am Acad Child Adolesc Psychiatry 37, 372-376.
25. Pappagallo, M. & Silva, R. (2004) The effect of atypical antipsychotic agents on prolactin levels in children and adolescents. J Child Adolesc Psychophasm 14, 359-371.
26. Saito, E., Correll, C. U., Gallelli, K., et al (2004) A prospective study of hyperprolactinaemia in children and adolescents treated with atypical antipsychotic agents. J Child Adolesc Psychopharm 14, 350-358.
27. Stevens, J. R., Kymissis, P. I. & Baker, A. J. L. (2005) Elevated prolactin in male youth treated with risperidone and quetiapine. J Child Adolesc Psychopharm 15, 893-900.
28. Snyder, R., Turgay, A., Aman, M. G., et al (2002) Effects of risperidone on conduct and disruptive behavior disorders in children with suhaverage IQs. J Am Acad Child Adolesc Psychiatry 41, 1026-1036.
29. Toren, P., Ratner, S., Laor, N., et al (2004) Benefit-risk assessment of atypical antipsychotics in the treatment of schizophrenia and comorbid disorders in children and adolescents. Drug Saf 27, 1135-1156.
30. Turgay, A., Binder, C., Snyder, R., et al (2002) Long-term safety and efficacy of Risperidone for the treatment of disruptive behavior disorders in children with subaverage IQs. Pediatrics 110, e34.
31. Turrone P., Kapur, S., Seeman, M. V., et al (2002) Elevation of prolactin levels by atypical antipsychotics. Am J Psychiatry 159, 133-135.
32. Wieck, A. & Haddad, P. M. (2003) Antipsychotic-induced hyperprolactinaemia in women: pathophysiology, severity and consequences. Br J Psychiatry, 182, 199-204.
33. Zarcone, J., R., Hellings, J., A., Crandall, K., et al (2001) Effects of risperidone on aberrant behavior of persons with developmental disabilities: I. A double-blind crossover study using multiple measures. Am J Ment Retard, 106, 25-538.
34. Zelaschi, N. M., Delucchi G. A. & Rodríguez, J. L. (1996) High plasma prolactin levels after long-term neuroleptic treatment. Biol Psychiatry, 39, 900-901.