3-Hydroxy-3-methylbutyrate administration diminishes fundectomy-induced osteopenia of the lumbar spine in pigs

Nutrition

Volumn 24, Issue 7-8, 2008, Pages 753-760

  Tatara, Marcin R ^a   Śliwa, Ewa ^a   Krupski, Witold ^b   Worzakowska, Marta ^c  

^a UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

3 Hydroxy 3 methylbutyrate; Fundectomy; Lumbar spine; Osteopenia; Pigs

Indexed keywords

AMINO ACID DERIVATIVE; CALCIUM 3 HYDROXY 3 METHYLBUTYRATE; HYDROXYAPATITE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE STRENGTH; BONE STRESS; BONE TISSUE; CONTROLLED STUDY; CORTICAL BONE; DRUG EFFECT; LUMBAR SPINE; LUMBAR VERTEBRA; MALE; MORPHOLOGY; NONHUMAN; OSTEOPENIA; PRIORITY JOURNAL; RIGIDITY; SWINE; TRABECULAR BONE; YOUNG MODULUS;

AMINO ACIDS; ANIMALS; BONE AND BONES; BONE DENSITY; BONE DISEASES, METABOLIC; GASTRIC FUNDUS; LUMBAR VERTEBRAE; MALE; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION; SWINE; VALERATES;

ANIMALIA; SUIDAE;

EID: 44749092398     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2008.03.009     Document Type: Article

References (30)

1. Zittel T.T., Zeeb B., Maier G.W., Kaiser W., Zwirner M., Liebich H., et al. High prevalence of bone disorders after gastrectomy. Am J Surg 174 (1997) 431-438
2. Heiskanen J.T., Kröger H., Pääkkönen M., Parviainen M.T., Lamberg-Allardt C., and Alhava E. Bone mineral metabolism after total gastrectomy. Bone 28 (2001) 123-127
3. Filipponi P., Gregorio F., Cristallini S., Mannarelli C., Blass A., Scarponi A.M., et al. Partial gastrectomy and mineral metabolism effects on gastrin-calcitonin release. Bone Miner 11 (1990) 199-208
4. Nilas L., Christiansen C., and Christiansen J. Regulation of vitamin D and calcium metabolism after gastrectomy. Gut 26 (1985) 252-257
5. Lehto-Axtelius D., Stenström M., and Johnell O. Osteopenia after gastrectomy, fundectomy or antrectomy: an experimental study in the rat. Regul Peptides 78 (1998) 41-50
6. Puzio I., Kapica M., Filip R., Bieńko M., and Radzki P.R. Fundectomy evokes elevated gastrin and lowered ghrelin serum levels accompanied by decrease in geometrical and mechanical properties of femora in rats. Bull Vet Inst Pulawy 49 (2005) 69-73
7. Suzuki Y., Fukushima S., Iwai T., Ishibashi Y., Omura N., Hanyu N., et al. Bisphosphonate incadronate prevents total gastrectomy-induced osteopenia in rats. Bone 35 (2004) 1346-1352
8. Tatara M.R., Krupski W., Śliwa E., Maciejewski R., and Dabrowski A. Fundectomy-evoked osteopenia in pigs is mediated by the gastric-hypothalamic-pituitary axis. Exp Biol Med 232 (2007) 1449-1457
9. Van Koevering M., and Nissen S. Oxidation of leucine and α-ketoisokaproate to β-hydroxy-β-methylbutyrate in vivo. Am J Physiol 262 (1992) E27-E31
10. Williams J., Abumrad N., and Barbul A. Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg 236 (2002) 369-375
11. Nissen S., and Abumrad N.N. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). J Nutr Biochem 8 (1997) 300-311
12. Nissen S., Sharp R., Ray M., Rathmacher J.A., Rice D., Fuller Jr. J.C., et al. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol 81 (1996) 2095-2104
13. Tatara M.R., Śliwa E., and Krupski W. Prenatal programming of skeletal development in the offspring: Effects of maternal treatment with β-hydroxy-β-methylbutyrate (HMB) on femur properties in pigs at slaughter age. Bone 40 (2007) 1615-1622
14. Tatara M.R., Brodzki A., Krupski W., Śliwa E., Silmanowicz P., Majcher P., et al. Effects of α-ketoglutarate on bone homeostasis and plasma amino acids in turkeys. Poult Sci 84 (2005) 1604-1609
15. Tatara M.R., Śliwa E., Krupski W., Brodzki A., and Pasternak K. Ornithine alpha-ketoglutarate increases mineralization and mechanical properties of tibia in turkeys. Bone 39 (2006) 100-105
16. Svedlund J., Sullivan M., Liedman B., and Lundell L. Long term consequences of gastrectomy for patients' quality of life: the impact of reconstructive techniques. Am J Gastroenterol 94 (1999) 438-445
17. Surve V.V., Andersson N., Alatalo S., Letho-Axtelius D., Halleen J., Vaananen K., et al. Does combined gastrectomy and ovariectomy induce greater osteopenia in young female rats than gastrectomy alone?. Calcif Tissue Int 69 (2001) 274-280
18. Schölmerich J. Postgastrectomy syndromes-diagnosis and treatment. Best Pract Res Cl Ga 18 (2004) 917-933
19. Surve V.V., Andersson N., Letho-Axtelius D., and Håkanson R. Comparison of osteopenia after gastrectomy, ovariectomy and prednisolone treatment in the young female rat. Acta Orthop Scand 72 (2001) 525-532
20. Piert M., Machulla H.-J., Jahn M., Stahlschmidt A., Becker G.A., and Zittel T.T. Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by [15O]H2O and [18F]fluoride ion positron emission tomography. Eur J Nucl Med 29 (2002) 907-914
21. Piert M., Zittel T.T., Jahn M., Stahlschmidt A., Becker G.A., and Machulla H.-J. Increased sensitivity in detection of a porcine high-turnover osteopenia after total gastrectomy by dynamic 18F-fluoride ion PET and quantitative CT. J Nucl Med 44 (2003) 117-124
22. Nissen S., Faidley T.D., Zimmerman D.R., Izard R., and Fisher T. Colostral milk fat percentage and pig performance are enhanced by feeding the leucine metabolite β-hydroxy-β-methyl butyrate to sows. J Anim Sci 72 (1994) 2331-2337
23. Tatara M.R., Krupski W., Majcher P., and Studziński T. Long-term denervation of the humerus in turkeys as an experimental model for osteopenia. Poult Sci 84 (2005) 718-722
24. Śliwa E., Kowalik S., Tatara M.R., Majcher P., Krupski W., and Studziński T. Effects of dexamethasone on physical properties and mineral density of long bones in piglets. Bull Vet Inst Pulawy 49 (2005) 97-100
25. Ferretti J.L., Gaffuri O., Capozza R., Cointry G., Bozzini C., Olivera M., Zanchetta J.R., et al. Dexamethasone effects on mechanical, geometric and densitometric properties of rat femur diaphyses as described by peripheral quantitative computerized tomography and bending tests. Bone 16 (1995) 119-124
26. Ito M., Nishida A., Nakamura T., Uetani M., and Hayashi K. Differences of three-dimensional trabecular microstructure in osteopenic rat models caused by ovariectomy and neurectomy. Bone 30 (2002) 594-598
27. Daugherty G. Quantitative CT in the measurement of bone quantity and bone quality for assessing osteoporosis. Med Eng Phys 18 (1996) 557-568
28. Stenström M., Olander B., Lehto-Axtelius D., Madsen J.E., Nordsletten L., and Carlsson G.A. Bone mineral density and bone structure parameters as predictors of bone strength: an analysis using computerized microtomography and gastrectomy-induced osteopenia in the rat. J Biomech 33 (2000) 289-297
29. Wallace J.M., Rajchar R.M., Chen X.-D., Shi S., Allen M.R., Bloomfield S.A., et al. The mechanical phenotype of biglycan-deficient mice is bone- and gender specific. Bone 39 (2006) 106-116
30. Xu T., Fisher L.W., Logenecker G., Smith E., Goldstein S., Bonadio J., et al. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet 20 (1998) 78-82