The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats

Journal of Neural Transmission

Volumn 115, Issue 5, 2008, Pages 677-681

  Kolasiewicz, W ^a   Maj, J ^a   Ossowska, K ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Cerebellum; Dopamine D3 receptors; Locomotor activity; Rat

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; N [4 (8 CYANO 1,3A,4,9B TETRAHYDRO 3H BENZOPYRANO[3,4 C]PYRROL 2 YL)BUTYL] (4 PHENYL) BENZAMIDE; S 33084;

ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; DOSE RESPONSE; DRUG INHIBITION; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR, ANIMAL; BENZOPYRANS; CEREBELLUM; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG INTERACTIONS; MALE; MOTOR ACTIVITY; PYRROLES; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D3; TETRAHYDRONAPHTHALENES;

EID: 44749090396     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0009-0     Document Type: Article

References (28)

1. Audinot V, Newman-Tancredi A, Gobert A, Rivet J-M, Brocco M, Lejeune F, Gluck L, Desposte I, Bervoets K, Dekeyne A, Millan MJ (1998) A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther 287:187-197
2. 3H]PD 128907, a putatively selective ligand for the D3 dopamine receptor, in rat brain: a receptor binding and quantitative autoradiographic study. Neuropsychopharmacology 18:305-316
3. Barik S, De Baurepaire R (1996) Evidence for a functional role of the dopamine D3 receptors in the cerebellum. Brain Res 737:347-350
4. Barik S, De Beaurepaire R (2005) Dopamine D3 modulation of locomotor activity and sleep in the nucleus accumbens and lobules 9 and 10 of the cerebellum in the rat. Progr Neuro-Psychopharmacol Biol Psychiat 29:718-726
5. Barili P, Bronzetti E, Ricci A, Zaccheo D, Amenta F (2000) Microanatomical localization of dopamine receptor protein immunoreactivity in the rat cerebellar cortex. Brain Res 854:130-138
6. Berthie B, Axelrad H, Verney C, Marc ME (1993) A small population of Purkinje cells in the posterior vermis is specifically labeled by tyrosine hydroxylase antibody. In: Trouillas P, Fuxe K (eds) Serotonin, the cerebellum and ataxia, Raven Press Ltd, New York, pp 121-127
7. 3 receptor mediated effect? Prog Neuro Psychopharmacol Biol Psychiat 24:39-49
8. Daly SA, Waddington JL (1993) Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like' agonists. Neuropharmacology 32:509-510
9. 3 receptor in the rat brain. Neuroscience 65:731-745
10. Diaz J, Pilon C, Le Foll B, Gross C, Triller A, Schwartz JC, Sokoloff P (2000) Dopamine D3 receptors expressed by all mesencephalic neurons. J Neurosci 20:8677-8684
11. Hurley MJ, Mash DC, Jenner P (2003) Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR. Eur J Pharmacol 18:2668-2672
12. Ikai Y, Takada M, Shinonaga Y, Mizuno N (1992) Dopaminergic and non-dopaminergic neurons in the ventral tegmental area of the rat project, respectively, to the cerebellar cortex and deep cerebellar nuclei. Neuroscience 51:719-728
13. Ishibashi T, Wakabayashi J, Ohno Y (2002) 7-Hydroxy-N,N′-di-n- propyl-2-aminotetraline, a preferential dopamine D3 agonist, induces c-fos mRNA expression in the rat cerebellum. Jpn J Pharmacol 89:309-315
14. Joyce JN, Millan MJ (2005) Dopamine D3 receptor antagonists as therapeutic agents. Drug Discov Today 10:917-925
15. Kizer JS, Palkovits M, Brownstein MJ (1976) The projections of the A8, A9 and A10 dopaminergic cell bodies: evidence for a nigral-hypothalamic-median eminence dopaminergic pathway. Brain Res 108:363-370
16. 3 receptor agonists. Pol J Pharmacol 53:509-515
17. Levant B, Bancroft GN, Selkirk CM (1996) In vivo occupancy of D2 dopamine receptors by 7-OH-DPAT. Synapse 24:60-64
18. Melchitzky DS, Lewis DA (2000) Tyrosine hydroxylase- and dopamine transporter-immunoreactivity axons in the primate cerebellum. Evidence for a lobular- and laminar-specific dopamine innervation. Neuropsychopharmacology 22:466-472
19. Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet J-M, Aubinot V, Dubuffet T, Lavielle G (2000a) S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther 293:1048-1062
20. 3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther 293:1063-1073
21. Millan MJ, Seguin L, Gobert A, Cussac D, Brocco M (2004) The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174:341-357
22. Panagopoulos NT, Panagopoulos GC, Matsokis NA (1991) Dopaminergic innervation and binding in the rat cerebellum. Neurosci Lett 130:208-212
23. Paxinos G, Watson C (1998) The rat brain, 4th edn. Academic Press, London
24. Perciavalle V, Beretta F, Raffaelle R (1989) Projections from the intracerebellar nuclei to the ventral midbrain tegmentum in the rat. Neuroscience 29:109-119
25. 3 receptor in the rat cerebellar cortex: a light microscope autoradiographic study. Neurosci Lett 190:163-166
26. Snider RS, Maiti A, Snider SR (1976) Cerebellar pathways to ventral midbrain and nigra. Exp Neurol 53:714-728
27. Takada M, Sugimoto T, Hattori T (1993) Tyrosine hydroxylase immunoreactivity in cerebellar Purkinje cells of the rat. Neurosci Lett 150:61-64
28. Voogd J, Glickstein M (1998) The anatomy of the cerebellum. Trends Cogn Sci 9:307-313