Distinctive IgVH gene segments usage and mutation status in Chinese patients with chronic lymphocytic leukemia

Leukemia Research

Volumn 32, Issue 10, 2008, Pages 1491-1498

  Chen, Lijuan ^a   Zhang, Yaping ^a   Zheng, Wenjuan ^a   Wu, Yujie ^a   Qiao, Chun ^a   Fan, Lei ^a   Xu, Wei ^a   Li, Jianyong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CD38 antigen; Chronic lymphocytic leukemia; Immunoglobulin heavy chain gene; Somatic hypermutation; ZAP 70

Indexed keywords

CD38 ANTIGEN; PROTEIN KINASE ZAP 70;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CHINESE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MAJOR CLINICAL STUDY; MALE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC MUTATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD38; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CHROMOSOME ABERRATIONS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN HEAVY CHAIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; TUMOR MARKERS, BIOLOGICAL; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 44749086562     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2008.02.005     Document Type: Article

References (36)

1. Mauerer K., Zahrieh D., Gorgun G., Li A.H., Zhou J.B., Ansen S., et al. Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemia. Br J Haematol 129 (2005) 499-510
2. Montillo M., Hamblin T., Hallek M., Montserrat E., and Morra E. Chronic lymphocytic leukemia: novel prognostic factors and their relevance for risk-adapted therapeutic strategies. Haematologica 90 (2005) 391-399
3. Hamblin T.J., Orchard J.A., Ibbotson R.E., Davis Z., Thomas P.W., Stevenson F.K., et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99 (2002) 1023-1028
4. Durig J., Nuckel H., Cremer M., Fuhrer A., Halfmeyer K., Fandrey J., et al. ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia. Leukemia 17 (2003) 2426-2434
5. Fais F., Ghiotto F., Hashimoto S., Sellars B., Valetto A., Allen S.L., et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 102 (1998) 1515-1525
6. Matsuda F., Ishii K., Bourvagnet P., Kuma K., Hayashida H., Miyata T., et al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 188 (1998) 2151-2162
7. Johnson T.A., Rassenti L.Z., and Kipps T.J. IgVH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 158 (1997) 235-246
8. Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., and Stevenson F.K. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94 (1999) 1848-1854
9. Widhopf G.F., and Kipps T.J. Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. J Immunol 166 (2001) 95-102
10. Potter K.N., Orchard J., Critchley E., Mockridge C.I., Jose A., and Stevenson F.K. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood 101 (2003) 3082-3084
11. Cheson B.D., Bennett J.M., Grever M., Kay N., Keating M.J., O'Brien S., et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87 (1996) 4990-4997
12. Binet J.L., Lepoprier M., Dighiero G., Charron D., D'Athis P., Vaugier G., et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 40 (1977) 855-864
13. Nakamura N., Kuze T., Hashimoto Y., Tasaki K., Hojo H., Sasaki Y., et al. Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms and B cell chronic lymphocytic leukemia in the Japanese population. Pathol Int 49 (1999) 595-600
14. Koiso H., Yamane A., Mitsui T., Matsushima T., Tsukamoto N., Murakami H., et al. Distinctive immunoglobulin VH gene usage in Japanese patients with CLL. Leuk Res 30 (2006) 272-276
15. Farsangi M.H., Jeddi-Tehrani M., Sharifian R.A., Razavi S.M., Khoshnoodi J., Rabbani H., et al. Analysis of the immunoglobulin heavy chain variable region gene expression in Iranian patients with chronic lymphocytic leukemia. Leuk Lymphoma 48 (2007) 109-116
16. Widhopf G.F., Rassenti L.Z., Toy T.L., Gribben J.G., Wierda W.G., and Kipps T.J. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 104 (2004) 2499-2504
17. Tobin G., Thunberg U., Karlsson K., Murray F., Laurell A., Willander K., et al. Subset with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 104 (2004) 2879-2885
18. Crespo M., Bosch F., Villamor N., Bellosillo B., Colomer D., Rozman M., et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 348 (2003) 1764-1775
19. Nardini E., Neri F., Vicenzi E., Poli G., Capello D., Gaidano G., et al. Thymic function and immunoglobulin mutation genotype in B-cell chronic lymphocytic leukemia patients. Int J Cancer 107 (2003) 958-961
20. Duke V.M., Gandini D., Sherrington P.D., Lin K., Heelan B., Amlot P., et al. VH gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia. Haematologica 88 (2003) 1259-1271
21. Tobin G., Soderberg O., Thunberg U., and Rosenquist R. V(H)3-21 gene usage in chronic lymphocytic leukemia-characterization of a new subgroup with distinct molecular features and poor survival. Leuk Lymphoma 45 (2004) 221-228
22. Thorsélius M., Kröber A., Murray F., Thunberg U., Tobin G., Bühler A., et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood 107 (2006) 2889-2894
23. Messmer B.T., Albesiano E., Messmer D., and Chiorazzi N. The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood 103 (2004) 3490-3495
24. Donisi P.M., Di Lorenzo N., Riccardi M., Paparella A., Sarpellon C., Zupo S., et al. Pattern and distribution of immunoglobulin VH gene usage in a cohort of B-CLL patients from a Northeastern region of Italy. Diagn Mol Pathol 15 (2006) 206-215
25. Ritgen M., Lange A., Stilgenbauer S., Dohner H., Bretscher C., Bosse H., et al. Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia. Blood 101 (2003) 2049-2053
26. Stamatopoulos K., Belessi C., Moreno C., Boudjograh M., Guida G., Smilevska T., et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 109 (2007) 259-270
27. Oppezzo P., and Dighiero G. What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis?. Curr Top Microbiol Immunol 294 (2005) 71-89
28. Boonstra J.G., van Lom K., Langerak A.W., Graveland W.J., Valk P.J., Kraan J., et al. CD38 as a prognostic factor in B cell chronic lymphocytic leukaemia (B-CLL): comparison of three approaches to analyze its expression. Cytometry B Clin Cytom 70 (2006) 136-141
29. Del Poeta G., Maurillo L., Venditti A., Buccisano F., Epiceno A.M., Capelli G., et al. Clinical significance of CD38 expression in chronic lymphocytic leukemia. Blood 98 (2001) 2633-2639
30. Ibrahim S., Keating M., Do K.A., O'Brien S., Huh Y.O., Jilani I., et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 98 (2001) 181-186
31. Hamblin T.J., Orchard J.A., Ibbotson R.E., Davis Z., Thomas P.W., Stevenson F.K., et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 99 (2002) 1023-1029
32. Chen Y.H., Peterson L.C., Dittmann D., Evens A., Rosen S., Khoong A., et al. Comparative analysis of flow cytometric techniques in assessment of ZAP-70 expression in relation to IgVH mutational status in chronic lymphocytic leukemia. Am J Clin Pathol 127 (2007) 182-191
33. Gábor MeHE.S. Chromosome abnormalities with prognostic impact in B-cell chronic lymphocytic leukemia. Pathol Oncol Res 11 (2005) 205-210
34. Dewald G.W., Brockman S.R., Paternoster S.F., Bone N.D., O'Fallon J.R., Allmer C., et al. Chromosome anomalies detected by fluorescence in situ hybridisation: correlation with significant biological features in B-cell chronic lymphocytic leukemia. Br J Haematol 121 (2003) 287-295
35. Doner H., Stilgenbauer S., Doner K., Bentz M., and Lichter P. Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis. J Mol Med 77 (1999) 266-281
36. Glassman A.B., and Hayes K.J. The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic lymphocytic leukemia. Cancer Genet Cytogenet 158 (2005) 88-91