Tx3-4 a toxin from the venom of spider Phoneutria nigriventer blocks calcium channels associated with exocytosis

Neuroscience Letters

Volumn 439, Issue 2, 2008, Pages 170-172

  de Castro Junior, Célio José ^a   Pinheiro, Ana Cristina N ^a   Guatimosim, Cristina ^b   Cordeiro, Marta N ^c   Souza, Alessandra H ^a   Richardson, Michael ^c   Romano Silva, Marco A ^b   Prado, Marco Antônio M ^a   Gomez, Marcus V ^a,d  

^a Departamento Farmacologia BeloHorizonte   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FUNDAÇÃO EZEQUIEL DIAS   (Brazil)

^d Universidade Federal de Minas Gerais BeloHorizonte ^*  (Brazil)

Author keywords

Aga IVA; CgTX GVIA; CgTX MVIIC; Calcium channels; Exocytosis; Phoneutria toxin; Synaptosomes

Indexed keywords

CALCIUM CHANNEL; POTASSIUM CHLORIDE; SPIDER VENOM; TX3 4 TOXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXOCYTOSIS; NONHUMAN; PHONEUTRIA NIGRIVENTER; PRIORITY JOURNAL; RAT; SPIDER; SYNAPSE VESICLE;

ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOCYTOSIS; MALE; NEUROPEPTIDES; NEUROTOXINS; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; SPIDER VENOMS; SYNAPTOSOMES;

EID: 44649200405     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.019     Document Type: Article

References (24)

1. Adams M.E., Myers R.A., Imperial J.S., and Olivera B.M. Toxityping rat brain calcium channels with omega-toxins from spider and cone snail venoms. Biochemistry 32 (1993) 12566-12570
2. 2+ channels to treat pain: T-type versus N-type. Trends Pharmacol. Sci. 25 (2004) 465-470
3. Araujo D.A., Cordeiro M.N., Diniz C.R., and Beirao P.S. Effects of a toxic fraction, PhTx2, from the spider Phoneutria nigriventer on the sodium current. Naunyn Schmiedebergs Arch. Pharmacol. 347 (1993) 205-208
4. Betz W.J., and Bewick G.S. Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science 255 (1992) 200-203
5. Cassola A.C., Jaffe H., Fales H.M., Castro Afeche S., Magnoli F., and Cipolla-Neto J. Omega-phonetoxin-IIA: a calcium channel blocker from the spider Phoneutria nigriventer. Pflugers Arch. 436 (1998) 545-552
6. Dunkley P.R., Heath J.W., Harrison S.M., Jarvie P.E., Glenfield P.J., and Rostas J.A. A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions. Brain Res. 441 (1988) 59-71
7. 2+ channels in mammalian central neurons. Trends Neurosci. 18 (1995) 89-98
8. Gomez M.V., Kalapothakis E., Guatimosim C., and Prado M.A. Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels. Cell. Mol. Neurobiol. 22 (2002) 579-588
9. Guatimosim C., Romano-Silva M.A., Cruz J.S., Beirao P.S., Kalapothakis E., Moraes-Santos T., Cordeiro M.N., Diniz C.R., Gomez M.V., and Prado M.A. A toxin from the spider Phoneutria nigriventer that blocks calcium channels coupled to exocytosis. Br. J. Pharmacol. 122 (1997) 591-597
10. 2+ oscillation frequency in GH3 cells. J. Neurochem. 72 (1999) 1472-1481
11. Marks B., and McMahon H.T. Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals. Curr. Biol. 8 (1998) 740-749
12. McDonough S.I., Boland L.M., Mintz I.M., and Bean B.P. Interactions among toxins that inhibit N-type and P-type calcium channels. J. Gen. Physiol. 119 (2002) 313-328
13. Meffert M.K., Premack B.A., and Schulman H. Nitric oxide stimulates Ca(2+)-independent synaptic vesicle release. Neuron 12 (1994) 1235-1244
14. Mintz I.M., Adams M.E., and Bean B.P. P-type calcium channels in rat central and peripheral neurons. Neuron 9 (1992) 85-95
15. Miranda D.M., Romano-Silva M.A., Kalapothakis E., Diniz C.R., Cordeiro M.N., Santos T.M., Prado M.A., and Gomez M.V. Phoneutria nigriventer toxins block tityustoxin-induced calcium influx in synaptosomes. Neuroreport 9 (1998) 1371-1373
16. 2+ channels. Neuron 17 (1996) 781-788
17. Olivera B.M., Miljanich G.P., Ramachandran J., and Adams M.E. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu. Rev. Biochem. 63 (1994) 823-867
18. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15 (1995) 2995-3012
19. Reuter H. Diversity and function of presynaptic calcium channels in the brain. Curr. Opin. Neurobiol. 6 (1996) 331-337
20. 2+ entry linked to rapid glutamate release: studies using the Phoneutria nigriventer toxin PhTX2 and potassium depolarisation. Biochem. J. 296 Pt 2 (1993) 313-319
21. Suszkiw J.B., Murawsky M.M., and Shi M. Further characterization of phasic calcium influx in rat cerebrocortical synaptosomes: inferences regarding calcium channel type(s) in nerve endings. J. Neurochem. 52 (1989) 1260-1269
22. Takahashi T., and Momiyama A. Different types of calcium channels mediate central synaptic transmission. Nature 366 (1993) 156-158
23. 2+ channel types coexist to regulate synaptosomal neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 9518-9522
24. 2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology 32 (1993) 1075-1088