Time-course of GDNF and its receptor expression after brain injury in the rat

Neuroscience Letters

Volumn 439, Issue 1, 2008, Pages 24-29

  Cheng, Qingzhang ^a   Di Liberto, Valentina ^a   Caniglia, Giuseppa ^a   Mudò, Giuseppa ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Brain injury; GDNF; GFR 1; GFR 2; In situ hybridization; RET

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CONTROLLED STUDY; CORPUS CALLOSUM; GENE EXPRESSION; GLIA CELL; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WHITE MATTER;

ANIMALS; AUTORADIOGRAPHY; BRAIN INJURIES; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; IBOTENIC ACID; MALE; RATS; RATS, WISTAR; RNA, MESSENGER; TIME FACTORS;

EID: 44649195643     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.04.089     Document Type: Article

References (17)

1. Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., Leitner M.L., Araki T., Johnson Jr. E.M., and Milbrandt J. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3-RET receptor complex. Neuron 21 (1998) 1291-1302
2. Batchelor P.E., Liberatore G.T., Wong J.Y., Porritt M.J., Frerichs F., Donnan G.A., and Howells D.W. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J. Neurosci. 19 (1999) 1708-1716
3. Belluardo N., Salin T., Dell'Albani P., Mudo G., Corsaro M., Jiang X.H., Timmusk T., and Condorelli D.F. Neurotoxic injury in rat hippocampus differentially affects multiple trkB and trkC transcripts. Neurosci. Lett. 196 (1995) 1-4
4. Bespalov M.M., and Saarma M. GDNF family receptor complexes are emerging drug targets. Trends Pharmacol. Sci. 28 (2007) 68-74
5. Bresjanac M., and Antauer G. Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRα1 as well as GDNF in vivo. Exp. Neurol. 164 (2000) 53-59
6. Henderson C.E., Phillips H.S., Pollock R.A., Davies A.M., Lemeulle C., Armanini M., Simmons L., Moffet B., Vandlen R.A., and Simpson L.C. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266 (1994) 1062-1064
7. Kokaia Z., Airaksinen M.S., Nanobashvili A., Larsson E., Kujamaki E., Lindvall O., and Saarma M. GDNF family ligands and receptors are differentially regulated after brain insults in the rat. Eur. J. Neurosci. 11 (1999) 1202-1216
8. Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson Jr. E.M., and Milbrandt J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 384 (1996) 467-470
9. Lin L.F., Doherty D.H., Lile J.D., Bektesh S., and Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260 (1993) 1130-1132
10. Masure S., Cik M., Hoefnagel E., Nosrat C.A., Van D.L., Scott I.R., Van Gompel P., Lesage A.S., Verhasselt P., Ibanez C.F., and Gordon R.D. Mammalian GFRα4, a divergent member of the GFRα family of coreceptors for GDNF family ligands, is a receptor for the neurotrophic factor persephin. J. Biol. Chem. 275 (2000) 39427-39434
11. Mudo G., Persson H., Timmusk T., Funakoshi H., Bindoni M., and Belluardo N. Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience 57 (1993) 901-912
12. Nosrat C.A., Tomac A., Hoffer B.J., and Olson L. Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Exp. Brain Res. 115 (1997) 410-422
13. Paxinos G., and Watson C. The Rat Brain In Stereotaxic Coordinates (1998), Academic Press, New York
14. Tomac A., Lindqvist E., Lin L.F., Ogren S.O., Young D., Hoffer B.J., and Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373 (1995) 335-339
15. Trupp M., Belluardo N., Funakoshi H., and Ibanez C.F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor- alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17 (1997) 3554-3567
16. Trupp M., Raynoschek C., Belluardo N., and Ibanez C.F. Multiple GPI-Anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Mol. Cell. Neurosci. 11 (1998) 47-63
17. Trupp M., Scott R., Whittemore S.R., and Ibanez C.F. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J. Biol. Chem. 274 (1999) 20885-20894