Expecting the unexpected

Anesthesia and Analgesia

Volumn 106, Issue 6, 2008, Pages 1605-1606

  Talke, Pekka O ^a   Maze, Mervyn ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; DEXMEDETOMIDINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; HYPNOTIC SEDATIVE AGENT;

ADRENERGIC ACTIVITY; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR DISSOCIATION; BRADYCARDIA; CARDIOVASCULAR EFFECT; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG POTENCY; EDITORIAL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART OUTPUT; HEMODYNAMIC PARAMETERS; HUMAN; HYPOTENSION; MORTALITY; PRIORITY JOURNAL; SIDE EFFECT; VAGUS NERVE STIMULATION; VASOCONSTRICTION; CARDIOGENIC SHOCK; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; HEART ATRIUM FIBRILLATION; HEART FUNCTION TEST; HEMODYNAMICS; NOTE; PATHOPHYSIOLOGY; RESUSCITATION; RISK FACTOR; TREATMENT FAILURE;

ADRENERGIC ALPHA-AGONISTS; ATRIAL FIBRILLATION; CARDIOPULMONARY RESUSCITATION; DEXMEDETOMIDINE; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEMODYNAMICS; HUMANS; HYPNOTICS AND SEDATIVES; RISK FACTORS; SHOCK, CARDIOGENIC; TREATMENT FAILURE;

EID: 44649187492     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31816c3f69     Document Type: Editorial

References (12)

1. Kamibayashi T, Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology 2000;93:1345-9
2. Ebert TJ, Hall JE, Barney JA, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000;93:382-94
3. Sichrovsky TC, Mittal S, Steinberg JS. Dexmedetomidine sedation leading to refractory cardiogenic shock. Anesth Analg 2008;106:1784-6
4. Shah AN, Koneru J, Nicoara A, Goldfeder L, Thomas K, Ehlert F. Dexmedetomidine related cardiac arrest in a patient with permanent pacemaker; a cautionary tale. Pacing Clin Electrophysiol 2007;30:1158-60
5. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thornborg P, Heard S, Cheung A, Son SL, Kallio A. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg 2000;90:834-9
6. Scheinin H, Aantaa R, Anttila M, Hakola P, Heiminen A, Karhuvaara S. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers. Anesthesiology 1998;89:574-84
7. Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL. The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology 1993;78:813-20
8. Peden CJ, Cloote AH, Stratford N, Prys-Roberts C. The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil. Anaesthesia 2001;56:408-13
9. Thormann J, Neuss H, Schlepper M, Mitrovic V. Effects of clonidine on sinus node function in man. Chest 1981;80:201-6
10. Roden DM, Nadeau JH, Primm RK. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther 1988;43:648-54
11. Clementy J, Castagne D, Wicker P, Dallocchio M, Bricaud H. Study of the electrophysiologic properties of clonidine administered intravenously. J Cardiovasc Pharmacol 1986;8:S24-9
12. Hammer GB, Drover DR, Cao H, Jackson E, Williams G, Ramamoorthy C, Van Hare G, Niksch A, Dubin A. The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg 2008;106:79-83