Caspase-related apoptosis in chronic ischaemic microangiopathy following experimental vein occlusion in mini-pigs

Acta Ophthalmologica

Volumn 86, Issue 3, 2008, Pages 302-306

  Donati, Guy ^a   Kapetanios, Anastasios ^a   Dubois Dauphin, Michel ^a   Pournaras, Constantin Jean ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b NONE   (Switzerland)

Author keywords

Apoptosis; Caspases; Chronic ischaemia; Experimental branch vein occlusion; Retina

Indexed keywords

ALANINE; ASPARTIC ACID; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; MICROANGIOPATHY; NERVE CELL LESION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RETINA EDEMA; RETINA INNER PLEXIFORM LAYER; RETINA ISCHEMIA; RETINA NECROSIS; RETINA NERVE CELL;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; ATROPHY; CASPASES; CHRONIC DISEASE; CYSTEINE PROTEINASE INHIBITORS; EDEMA; IN SITU NICK-END LABELING; INJECTIONS; ISCHEMIA; MICROCIRCULATION; NECROSIS; NEUROPROTECTIVE AGENTS; RETINA; RETINAL DISEASES; RETINAL VEIN OCCLUSION; RETINAL VESSELS; SWINE; SWINE, MINIATURE; TIME FACTORS; VITREOUS BODY;

EID: 44649185641     PISSN: 1755375X     EISSN: 16000420     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2007.01044.x     Document Type: Article

References (18)

1. Barinaga M (1998): Stroke-damaged neurons may commit cellular suicide. Science 281: 1302-1303.
2. de Bilbao F & Dubois-Dauphin M (1996): Time-course of axotomy-induced apoptotic cell death in facial motoneurons of neonatal wild type and bcl-2 transgenic mice. Neuroscience 71: 1111-1119.
3. Donati G, Pournaras CJ, Munoz JL et al. (1995): Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci 36: 2228-2237.
4. Donati G, Pournaras CJ, Pizzolato JP et al. (1997): Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci 38: 1450-1457.
5. Donati G, Pournaras CJ, Tsacopoulos M et al. (1998): Effect of nitroprusside on arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci 39: 1910-1917.
6. Gwag BJ, Lobner D, Koh JY et al. (1995): Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro. Neuroscience 68: 615-619.
7. Hara H, Friedlander RM, Gagliardini V et al. (1997): Inhibition of interleukin-1β converting enzyme family proteases reduces ischaemic and excitotoxic neuronal damage. Proc Natl Acad Sci U S A 94: 2007-2012.
8. Joo CK, Choi JS, Ko HW et al. (1999): Necrosis and apoptosis after retinal ischaemia: Involvement of NMDA-mediated excitotoxicity and p53. Invest Ophthalmol Vis Sci 40: 713-720.
9. Kohner EM, Dollery CT, Shakib M et al. (1970): Experimental retinal branch vein occlusion. Am J Ophthalmol 69: 778-825.
10. Lam TT, Abler AS & Tso MO (1999): Apoptosis and caspases after ischaemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci 40: 967-975.
11. Loddick SA, MacKenzie A & Rothwell NJ (1996): An ICE inhibitor, z-VAD-DCB, attenuates ischaemic brain damage in the rat. Neuroreport 7: 1465-1468.
12. Martinou JC, Dubois-Dauphin M, Staple JK et al. (1994): Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischaemia. Neuron 13: 1017-1030.
13. Olney JW (1982): The toxic effects of glutamate and related compounds in the retina and the brain. Retina 2: 341-359.
14. Pournaras CJ (1995): Retinal oxygen distribution. Its role in the physiopathology of vasoproliferative microangiopathies. Retina 15: 332-347.
15. 2 in the retina of anaesthetized miniature pigs in normoxia and hyperoxia. Exp Eye Res 49: 347-360.
16. Pournaras CJ, Tsacopoulos M, Strommer K et al. (1990): Experimental retinal branch vein occlusion in miniature pigs induces local tissue hypoxia and vasoproliferative microangiopathy. Ophthalmology 97: 1321-1328.
17. Sennlaub F, Courtois Y & Goureau O (2002): Inducible nitric oxide synthase mediates retinal apoptosis in ischaemic proliferative retinopathy. J Neurosci 22: 3987-3993.
18. Zhang Y, Cho CH, Atchaneesysaul L et al. (2005): Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion. Invest Ophthalmol Vis Sci 46: 2133-2139.