-
1
-
-
0035908493
-
Blocking oncogenic Ras signaling for cancer therapy
-
Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001;93:1062-1074.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1062-1074
-
-
Adjei, A.A.1
-
2
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLos Med 2005;2:e17.
-
(2005)
PLos Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
5
-
-
0025293818
-
Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products
-
Suzuki Y, Orita M, Shiraishi M, Hayashi K, Sekiya T. Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene 1990;5:1037-1043.
-
(1990)
Oncogene
, vol.5
, pp. 1037-1043
-
-
Suzuki, Y.1
Orita, M.2
Shiraishi, M.3
Hayashi, K.4
Sekiya, T.5
-
7
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral anti-tumor activity and targets the Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral anti-tumor activity and targets the Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
8
-
-
33749263469
-
Analysis of transcription and protein expression changes in the 786-O human renal cell carcinoma tumor xenograft model in response to treatment with the multi-kinase inhibitor sorafenib (BAY 43-9006)
-
abstract and oral presentation
-
Levy AP, Pauloski N, Braun D, et al. Analysis of transcription and protein expression changes in the 786-O human renal cell carcinoma tumor xenograft model in response to treatment with the multi-kinase inhibitor sorafenib (BAY 43-9006). Proc Am Assoc Cancer Res 2006;47:213-214 (abstract and oral presentation).
-
(2006)
Proc Am Assoc Cancer Res
, vol.47
, pp. 213-214
-
-
Levy, A.P.1
Pauloski, N.2
Braun, D.3
-
9
-
-
27144502652
-
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
-
Yu C, Bruzek LM, Meng XW, et al. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene 2005;24:6861-6869.
-
(2005)
Oncogene
, vol.24
, pp. 6861-6869
-
-
Yu, C.1
Bruzek, L.M.2
Meng, X.W.3
-
10
-
-
23044510046
-
Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors
-
Clark JW, Eder JP, Ryan D, Lathia C, Lenz HJ. Safety and pharmacokinetics of the dual action Raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors. Clin Cancer Res 2005;11:5472-5480.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5472-5480
-
-
Clark, J.W.1
Eder, J.P.2
Ryan, D.3
Lathia, C.4
Lenz, H.J.5
-
11
-
-
20344362911
-
Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
-
Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer 2005;92:1855-1861.
-
(2005)
Br J Cancer
, vol.92
, pp. 1855-1861
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
-
12
-
-
27144527372
-
Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
-
Moore M, Hirte HW, Siu L, et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol 2005;16:1688-1694.
-
(2005)
Ann Oncol
, vol.16
, pp. 1688-1694
-
-
Moore, M.1
Hirte, H.W.2
Siu, L.3
-
13
-
-
20044382799
-
Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
Strumberg D, Richly H, Hilger RA, et al. Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005;23:965-972.
-
(2005)
J Clin Oncol
, vol.23
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
-
14
-
-
33646865114
-
Randomized phase III trial of the multi-kinase inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
-
Escudier B, Szczylik C, Eisen T, et al. Randomized phase III trial of the multi-kinase inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). Eur J Cancer Suppl 2005;3:226.
-
(2005)
Eur J Cancer Suppl
, vol.3
, pp. 226
-
-
Escudier, B.1
Szczylik, C.2
Eisen, T.3
-
15
-
-
34249093653
-
Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small-cell lung cancer
-
Adjei AA, Molina JR, Marks R, et al. Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small-cell lung cancer. Clin Cancer Res 2007;13:2684-2691.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2684-2691
-
-
Adjei, A.A.1
Molina, J.R.2
Marks, R.3
-
16
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
Rinehart J, Adjei AA, Lorusso PM, et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 2004;22:4456-4462.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
Lorusso, P.M.3
-
17
-
-
31544450194
-
A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer
-
Lorusso P, Krishnamurthi S, Rinehart JR, et al. A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer. J Clin Oncol (Meeting Abstr) 2005;23:3011.
-
(2005)
J Clin Oncol (Meeting Abstr)
, vol.23
, pp. 3011
-
-
Lorusso, P.1
Krishnamurthi, S.2
Rinehart, J.R.3
-
18
-
-
33646402805
-
Pharmacokinetics (PK) and pharmacodynamics (PD) of PD 0325901, a second generation MEK inhibitor after multiple oral doses of PD 0325901 to advanced cancer patients
-
Menon SS, Whitfield LR, Sadis S, et al. Pharmacokinetics (PK) and pharmacodynamics (PD) of PD 0325901, a second generation MEK inhibitor after multiple oral doses of PD 0325901 to advanced cancer patients. J Clin Oncol (Meeting Abstr). 2005;23:3066.
-
(2005)
J Clin Oncol (Meeting Abstr)
, vol.23
, pp. 3066
-
-
Menon, S.S.1
Whitfield, L.R.2
Sadis, S.3
-
20
-
-
84871392004
-
-
Available at:, Accessed October 15, 2007
-
Pfizer Pipeline. Available at: http://www.pfizer.com/research/pipeline. jsp. Accessed October 15, 2007.
-
Pfizer Pipeline
-
-
-
21
-
-
44649179282
-
Phase IB and pharmacodynamic study of the MEK inhibitor AZD6244 (ARRY-142886) in patients with advanced solid malignancies
-
November
-
Adjei AA, Cohen RB, Franklin WA, Molina J. Phase IB and pharmacodynamic study of the MEK inhibitor AZD6244 (ARRY-142886) in patients with advanced solid malignancies. AACR-EORTC-NCI Molecular Targets Meeting, November 2006.
-
(2006)
AACR-EORTC-NCI Molecular Targets Meeting
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.A.3
Molina, J.4
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