Forum: The case for gene-environment interactions in psychiatry

Current Opinion in Psychiatry

Volumn 21, Issue 4, 2008, Pages 318-321

  Uher, Rudolf ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CANNABIS; CATECHOL METHYLTRANSFERASE; SEROTONIN TRANSPORTER;

DNA POLYMORPHISM; ENVIRONMENTAL EXPOSURE; GENE INTERACTION; GENOTYPE; HEREDITY; HUMAN; LIFE STRESS; LIPID METABOLISM; PSYCHIATRY; PSYCHOSIS; QUANTITATIVE ANALYSIS; REVIEW;

ENVIRONMENT; EPIDEMIOLOGIC METHODS; GENETIC PREDISPOSITION TO DISEASE; GENETICS, MEDICAL; HUMANS; MENTAL DISORDERS;

EID: 44649133964     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/YCO.0b013e328306a7b9     Document Type: Review

References (24)

1. Cadoret RJ. Genotype-environment interaction in antisocial behaviour. Psychol Med 1982; 12:235-239.
2. Caspi A, McClay J, Moffitt TE, et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297:851-854.
3. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301:386-389.
4. Caspi A, Moffitt TE, Cannon M, et al. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-o-methyltransferase gene: longitudinal evidence of a gene x environment interaction. Biol Psychiatry 2005; 57:1117-1127.
5. Neuman RJ, Lobos E, Reich W, et al. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry 2007; 61:1320-1328.
6. Rothman KJ, Greenland S. Modern epidemiology. 2nd ed. Philadelphia: Lippincott-Raven; 1998.
7. Aiken LS, West SG. Multiple regression: testing and interpreting interactions. Thousand Oaks: Sage Publications; 1991.
8. Sham PC. Types of gene-environment interplay and their statistical properties. In: MacCabe J, O'Daly O, Murray R, et al., editors. Beyond nature and nurture in psychiatry: genes, environment and their interplay. London: Informa Healthcare; 2006. pp. 11-17.
9. Rutter M. Genes and behavior. Oxford, UK: Blackwell; 2006.
10. Badyaev AV. Stress-induced variation in evolution: from behavioural plasticity to genetic assimilation. Proc Biol Sci 2005; 272:877-886.
11. Brown GW, Harris TO. Social origins of depression: a study of psychiatric disorder in women. 5th ed. London: Routledge; 1978.
12. Kendler KS, Myers JM, Neale MC. A multidimensional twin study of mental health in women. Am J Psychiatry 2000; 157:506-513.
13. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001; 29:306-309.
14. Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 2005; 62:473-481.
15. Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 2006; 7:583-590.
16. Caspi A, Williams B, Kim-Cohen J, et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci U S A 2007; 104:18860-18865.
17. Uher R. Gene-environment interaction: overcoming methodological challenges. In: Novartis Foundation Symposium 293: Understanding how gene-environment interactions work to predict disorder: a life course approach. Chichester: John Wiley & Sons; 2008.
18. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 2008; 13:131-146.
19. Taylor A, Kim-Cohen J. Meta-analysis of gene-environment interactions in developmental psychopathology. Dev Psychopathol 2007; 19:1029-1037.
20. Rutter M. Proceeding from observed correlation to causal inference: the use of natural experiments. Perspect Psychol Sci (in press).
21. Eaves LJ. Genotype x environment interaction in psychopathology: fact or artifact? Twin Res Hum Genet 2006; 9:1-8.
22. Knol MJ, van der Tweel I, Grobbee DE, et al. Estimating interaction on an additive scale between continuous determinants in a logistic regression model. Int J Epidemiol 2007; 36:1111-1118.
23. Brown GW. Genetic and population perspectives on life events and depression. Soc Psychiatry Psychiatr Epidemiol 1998; 33:363-372.
24. Martinez FD. CD14, endotoxin, and asthma risk: actions and interactions. Proc Am Thorac Soc 2007; 4:221-225.