Pharmacokinetics and analgesic effects of intravenous propacetamol vs rectal paracetamol in children after major craniofacial surgery

Paediatric Anaesthesia

Volumn 18, Issue 7, 2008, Pages 582-592

  Prins, Sandra A ^b   Van Dijk, Monique ^b   Van Leeuwen, Pim ^b   Searle, Susan ^b   Anderson, Brian J ^c   Tibboel, Dick ^b   Mathot, Ron A A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Analgesic effects; Children; Intravenous paracetamol; Pharmacokinetics

Indexed keywords

MIDAZOLAM; PARACETAMOL; PLACEBO; PROPACETAMOL;

ANALGESIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANIOFACIAL SURGERY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; INFANT; MALE; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VISUAL ANALOG SCALE;

ACETAMINOPHEN; ADMINISTRATION, RECTAL; ANALGESIA; ANALGESICS; ANESTHETICS, INTRAVENOUS; CHILD, PRESCHOOL; CRANIOFACIAL ABNORMALITIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; MIDAZOLAM; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PLACEBOS; TREATMENT OUTCOME;

EID: 44649128114     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2008.02619.x     Document Type: Article

References (29)

1. Anderson BJ, Woolard GA, Holford NH. Pharmacokinetics of rectal paracetamol after major surgery in children. Paediatr Anaesth 1995 5 : 237 242.
2. Bertin L, Pons G, d'Athis P et al. Randomized double-blind, multicenter controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children. J Pediatr 1991 119 : 811 814.
3. Anderson BJ, Holford NHG, Woollard GA et al. Perioperative pharmacodynamics of acetaminophen analgesia in children. Anesthesiology 1999 90 : 411 421.
4. Anderson BJ, Woollard GA, Holford NHG. Acetominophen analgesia in children: placebo effect and pain resolution after tonsillectomy. Eur J Clin Pharmacol 2001 57 : 559 569.
5. Gaudreault P, Guay J, Nicol O et al. Pharmacokinetics and clinical efficacy of intrarectal solution of acetaminophen. Can J Anaesth 1988 35 : 149 152.
6. Anderson B, Kanagasundarum S, Woollard G. Analgesic efficacy of paracetamol in children using tonsillectomy as a pain model. Anaesth Intensive Care 1996 24 : 669 673.
7. Van der Marel CD, van Lingen RA, Pluim MA et al. Analgesic efficacy of rectal versus oral acetaminophen in children after major craniofacial surgery. Clin Pharmacol Ther 2001 70 : 82 90.
8. Arana A, Morton NS, Hansen TG. Treatment with paracetamol in infants. Acta Anaesthesiol Scand 2001 45 : 20 29.
9. Birmingham PK, Tobin MJ, Fisher DM et al. Initial and subsequent dosing of rectal acetaminophen in children: a 24-hour pharmacokinetic study of new dose recommendations. Anesthesiology 2001 94 : 385 389.
10. Montgomery CJ, McCormack JP, Reichert CC et al. Plasma concentrations after high-dose (45 mg.kg-1) rectal acetaminophen in children. Can J Anaesth 1995 42 : 982 986.
11. Depré M, van Hecken A, Verbesselt R et al. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Fundam Clin Pharmacol 1992 6 : 259 262.
12. Autret E, Dutertre JP, Breteau M et al. Pharmacokinetics of paracetamol in the neonate and infant after administration of propacetamol chlorhydrate. Dev Pharmacol Ther 1993 20 : 129 134.
13. Van Dijk M, de Boer JB, Koot HM et al. The reliability and validity of the COMFORT scale as a postoperative pain instrument in 0 to 3-year-old infants. Pain 2000 84 : 367 377.
14. Ambuel B, Hamlett KW, Marx CM et al. Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol 1992 17 : 95 109.
15. McGrath P, Johnson G, Goodman JT et al. CHEOPS: A Behavioral Scale for Rating Postoperative Pain in Children. New York : Raven Press, 1985.
16. Hendrickson M, Myre L, Johnson DG et al. Postoperative analgesia in children: a prospective study of intermittent intramuscular injection versus continuous intravenous infusion of morphine. J Pediatr Surg 1990 25 : 185 191.
17. Romsing J, Moller-Sonnergaard J, Hertel S et al. Postoperative pain in children: comparison between ratings of children and nurses. J Pain Symptom Manage 1996 11 : 42 46.
18. Tarbell SE, Cohen IT, Marsh JL. The Toddler-Preschooler Postoperative Pain Scale: an observational scale for measuring postoperative pain in children aged 1-5. Preliminary report. Pain 1992 50 : 273 280.
19. Granry JC, Rod B, Monrigal JP et al. The analgesic efficacy of an injectable prodrug of acetaminophen in children after orthopaedic surgery. Paediatr Anaesth 1997 7 : 445 449.
20. Anderson BJ, McKee AD, Holford NHG. Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients. Clin Pharmacokinet 1997 33 : 313 327.
21. Anderson BJ, Woolard GA, Holford NHG. A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children. Br J Clin Pharmacol 2000 50 : 125 134.
22. European Medicines Agency, Committee for Medicinal Products for Human Use (CHMP). Guideline on Reporting the Results of Population Pharmacokinetic Analyses. London, 21 June, 2007, CHMP/EWP/185990/06, http://www.emea.europa.eu/ pdfs/human/ewp/18599006enfin.pdf.
23. Hahn TW, Henneberg SW, Holm-Knudsen RJ et al. Pharmacokinetics of rectal paracetamol after repeated dosing in children. Br J Anaesth 2000 85 : 512 519.
24. Coulthard KP, Nielson HW, Schröder M et al. Relative bioavailability and plasma paracetamol profiles of Panadol suppositories in children. Paediatr Child Health 1998 34 : 425 431.
25. Takatori T, Shimono N, Higaki K et al. Evaluation of sustained release suppositories prepared with fatty base including solid fats with high melting points. Int J Pharm 2004 278 : 275 282.
26. Muranishi S. Characteristics of drug absorption via the rectal route. Methods Find Exp Clin Pharmacol 1984 6 : 763 772.
27. Allegaert K, Van der Marel CD, Debeer A et al. Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age. Arch Dis Child Fetal Neonatal Ed 2004 89 : F25 F28.
28. Wurthwein G, Koling S, Reich A et al. Pharmacokinetics of intravenous paracetamol in children and adolescents under major surgery. Eur J Clin Pharmacol 2005 60 : 883 888.
29. Anderson B, Pons G., Autret-Leca E. et al. Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis. Pediatr Anesth 2005 15 : 282 292.