The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma

Journal of Pathology

Volumn 215, Issue 2, 2008, Pages 118-125

  Lucas, J M ^a   True, L ^b   Hawley, S ^a   Matsumura, M ^a   Morrissey, C ^c   Vessella, R ^c,d   Nelson, P S ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gleason grade; Immunohistochemistry; Membrane bound; Metastasis; Protease

Indexed keywords

ANDROGEN; HEPSIN; MATRIPTASE; MONOCLONAL ANTIBODY; PROTEOME; SERINE PROTEINASE; TRANSMEMBRANE SERINE PROTEASE 2;

ARTICLE; BREAST EPITHELIUM; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MEMBRANE; COLON MUCOSA; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ENZYME REGULATION; EPIDIDYMIS; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC BILE DUCT; KIDNEY; LEYDIG CELL; MALE; METASTASIS; PANCREAS ACINUS; PRIORITY JOURNAL; PROSTATE; PROSTATE ADENOCARCINOMA; PROSTATE HYPERTROPHY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEMINAL PLASMA; SENSITIVITY AND SPECIFICITY; STATISTICAL SIGNIFICANCE; STOMACH EPITHELIUM; TUMOR CELL;

ADENOCARCINOMA; ANIMALS; ANTIBODIES, MONOCLONAL; CELL MEMBRANE; CYTOPLASM; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICE; PROSTATIC NEOPLASMS; SERINE ENDOPEPTIDASES;

EID: 44649106949     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2330     Document Type: Article

References (15)

1. Lin B, Ferguson C, White JT, Wang S, Vessella R, True LD, et al. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res 1999;59(17):4180-4184.
2. Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. Genomics 1997;44(3):309-320.
3. Afar DE, Vivanco I, Hubert RS, Kuo J, Chen E, Saffran DC, et al. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. Cancer Res 2001;61(4):1686-1692.
4. Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005;310(5748):644-648.
5. Wilson S, Greer B, Hooper J, Zijlstra A, Walker B, Quigley J, et al. The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. Biochem J 2005;388(3):967-972.
6. Noguchi M, Stamey TA, McNeal JE, Nolley R. Prognostic factors for multifocal prostate cancer in radical prostatectomy specimens: lack of significance of secondary cancers. J Urol 2003;170(2, 1):459-463.
7. Utleg AG, Yi EC, Xie T, Shannon P, White JT, Goodlett DR, et al. Proteomic analysis of human prostasomes. Prostate 2003;56(2):150- 161.
8. Roudier MP, True LD, Higano CS, Vesselle H, Ellis W, Lange P, et al. Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone. Hum Pathol 2003;34(7):646-653.
9. Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, Bugge TH, et al. Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metast Rev 2003;22(2-3):237-258.
10. Szabo R, Wu Q, Dickson RB, Netzel-Arnett S, Antalis TM, Bugge TH. Type II transmembrane serine proteases. Thromb Haemost 2003;90(2):185- 193.
11. Bayer CA, Halsell SR, Fristrom JW, Kiehart DP, von Kalm L. Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. Genetics 2003;165(3):1417-1432.
12. Kim TS, Heinlein C, Hackman RC, Nelson PS. Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol 2006;26(3):965-975.
13. Bottcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J Virol 2006;80(19):9896-9898.
14. Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2004;2(7):395-402.
15. Golubkov VS, Chekanov AV, Savinov AY, Rozanov DV, Golubkova NV, Strongin AY. Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells. Cancer Res 2006;66(21):10460-10465.