Heavy metal and mineral concentrations and their relationship to histopathological findings in the bowhead whale (Balaena mysticetus)

Science of the Total Environment

Volumn 399, Issue 1-3, 2008, Pages 165-178

  Rosa, Cheryl ^a,d   Blake, John E ^a   Bratton, Gerald R ^b   Dehn, Larissa A ^a,e   Gray, Matthew J ^c   O'Hara, Todd M ^a  

^a UNIVERSITY OF ALASKA FAIRBANKS   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d DEPARTMENT OF WILDLIFE MANAGEMENT   (United States)

^e ALASKA DEPARTMENT OF FISH AND GAME   (United States)

Author keywords

Balaena mysticetus; Bowhead whale; Cadmium; Histology; Marine mammals; Toxicology

Indexed keywords

HEAVY METALS; HISTOLOGY; HYDROCARBONS; PATHOLOGY;

BALAENA MYSTICETUS; BOWHEAD WHALES; MARINE MAMMALS; TOXICOLOGY;

MAMMALS;

CADMIUM; COPPER; MERCURY; SELENIUM; SILVER; ZINC;

ARCTIC ENVIRONMENT; BIOACCUMULATION; CADMIUM; CONCENTRATION (COMPOSITION); ENDANGERED SPECIES; EPIDEMIOLOGY; HEALTH IMPACT; HEALTH STATUS; HEAVY METAL; HISTOLOGY; HISTOPATHOLOGY; HYDROCARBON; POLLUTION EFFECT; PUBLIC HEALTH; TOXICOLOGY; WHALE;

ANIMAL CARE; ANIMAL HEALTH; ANIMAL TISSUE; ARTICLE; BOWHEAD WHALE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; KIDNEY FIBROSIS; LUNG FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL;

AGE FACTORS; ALASKA; ANIMALS; ARCTIC REGIONS; BOWHEAD WHALE; CADMIUM; FIBROMUSCULAR DYSPLASIA; FIBROSIS; HISTOLOGICAL TECHNIQUES; KIDNEY; LIVER; LUNG; METALS, HEAVY; MINERALS; RISK ASSESSMENT; TISSUE DISTRIBUTION; WATER POLLUTANTS, CHEMICAL;

ALASKA; BARROW; BARTER ISLAND; KAKTOVIK; NORTH AMERICA; UNITED STATES; WAINWRIGHT;

BALAENA MYSTICETUS; BALAENIDAE; CETACEA; MAMMALIA;

EID: 44649097532     PISSN: 00489697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2008.01.062     Document Type: Article

References (71)

1. Aughey E., Fell G.S., Scott R., and Black M. Histopathology of early effects of oral cadmium in the rat kidney. Environ Health Perspect 54 (1984) 153-161
2. Barbier O., Jaquillet G., Tauc M., Cougnon M., and Poujeol P. Effect of heavy metals on, and handling by, the kidney. Nephron Physiol 99 (2005) 105-110
3. Barbier O., Dauby A., Jaquillet G., Tauc M., Poujeol P., and Cougnon M. Zinc and cadmium interactions in a renal cell line derived from rabbit proximal tubule. Nephron Physiol 99 (2005) 74-84
4. Bard S.M. Global transport of anthropogenic contaminants and the consequences for the Arctic marine ecosystem. Mar Pollut Bull 38 (1999) 356-379
5. Becker P.R., Mackey E.A., Demiralp R., Suydam R., Early G., Koster B.J., et al. Relationship of silver with selenium and mercury in the liver of two species of toothed whales (odontocetes). Mar Pollut Bull 30 (1995) 262-271
6. Becker PR, Mackey EA, Schantz MM, Demiralp R, Greenberg RR. Concentrations of chlorinated hydrocarbons, heavy metals and other elements in tissues banked by the Alaska marine mammal tissue archival project. In: National Inst. of Standards and Technology [CSTL], Gaithersburg, MD, United States, 1995b; 124 pp.
7. Beiglbock C., Steineck T., Tataruch F., and Ruf T. Environmental cadmium induces histopathological changes in kidneys of roe deer. Environ Toxicol Chem 21 (2002) 1811-1816
8. Bernard A. Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals 17 (2004) 519-523
9. Bratton GR, Spainhour CB, Flory W, Reed M, Jayko K. Presence and potential effects of contaminants. In Burns, J.J., Montague, J.J., Cowles, C.J., editors. The Bowhead Whale. Special Publication Number 2 The Society for Marine Mammalogy. Lawrence, KS Allen Press, Inc. 1993; pp. 701-744.
10. Bratton G.R., Flory W., Spainhour C.B., and Haubold E.M. Assessment of selected heavy metals in liver, kidney, muscle, blubber, and visceral fat of Eskimo harvested bowhead whales from Alaska's north coast. Final Report (North Slope Borough, Department of Wildlife Management) Barrow, Alaska (1997) [233 pp]
11. Braune B.M., Norstrom R.J., Wong M.P., Collins B.T., and Lee J. Geographical distribution of metals in livers of polar bears from the Northwest Territories, Canada. Sci Total Environ 100 (1991) 283-299
12. Caurant F., Navarro M., and Amiard J.-C. Mercury in pilot whales: possible limits to the detoxification process. Sci Total Environ 186 (1996) 95-104
13. Damek-Poprawa M., and Sawicka-Kapusta K. Damage to the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworks and zinc smelters in Poland. Toxicology 186 (2003) 1-10
14. Das K., Debacker V., and Bouquegneau J.M. Metallothioneins in marine mammals. Cell Mol Biol 46 (2000) 283-294
15. Dehn L.-A., Sheffield G.G., Follmann E.H., Duffy L.K., Thomas D.L., Bratton G.R., et al. Trace elements in tissues of phocid seals harvested in the Alaskan and Canadian Arctic: influence of age and feeding ecology. Can J Zool 83 (2005) 726-746
16. Dehn L.-A., Follmann E.H., Rosa C., Duffy L.K., Thomas D.L., Bratton G.R., et al. Stable isotope and trace element status of subsistence-hunted bowhead and beluga whales in Alaska and gray whales in Chukotka. Mar Pollut Bull 52 (2006) 301-319
17. Dehn L.-A., Follmann E.H., Thomas D.L., Sheffield G.G., Rosa C., Duffy L.K., et al. Trophic relationships in an Arctic food web and implications for trace metal transfer. Sci Total Environ 362 (2006) 103-123
18. Dietz R., Riget F., and Johansen P. Lead, cadmium, mercury and selenium in Greenland marine animals. Sci Total Environ 186 (1996) 67-93
19. Dietz R., Norgaard J., and Hansen J.C. Have Arctic marine mammals adapted to high cadmium levels?. Mar Pollut Bull 36 (1998) 490-492
20. Dietz R., Riget F., and Born E.W. An assessment of selenium to mercury in Greenland marine animals. Sci Tot Environ 245 (1999) 15-24
21. Dietz R., Riget F., and Born E.W. Geographical differences of zinc, cadmium, mercury and selenium in polar bears (Ursus maritimus) from Greenland. Sci Total Environ 245 (1999) 25-47
22. George J.C., Bada J., Zeh J., Scott L., Brown S., O'Hara T., et al. Age and growth estimates of bowhead whales (Balaena mysticetus) via aspartic acid racemization. Can J Zool 77 (1999) 571-580
23. Goyer R.A. Toxic Effects of Metals. In: Klaassen C.D. (Ed). Casarett and Doull's Toxicology: the basic science of poisons (1996), McGraw-Hill, New York 691-736
24. Herwig R.P., Staley J.T., Nerini M.K., and Braham H.W. Baleen whales: preliminary evidence for forestomach microbial fermentation. Appl Environ Microbiol 47 (1984) 421-423
25. Hoekstra P.F., Letcher R.J., Backus S.M., O'Hara T.M., Solomon K.R., and Muir D.C.G. Hydroxylated and methylsulfone-containing metabolites of polychlorinated biphenyls in plasma and blubber of bowhead whales (Balaena mysticetus). Environ Toxicol Chem 22 (2003) 2650-2658
26. Honda K., Yamamoto Y., Kato H., and Tatsukawa R. Heavy metal accumulations and their recent changes in southern minke whales Balaenoptera acutorostrata. Arch Environ Contam Toxicol 16 (1987) 209-216
27. Ikemoto T., Kunito T., Tanaka H., Baba N., Miyazaki N., and Tanabe S. Detoxification mechanism of heavy metals in marine mammals and seabirds: interaction of selenium with mercury, silver, copper, zinc, and cadmium in liver. Arch Environ Contam Toxicol 47 (2004) 402-413
28. Johnson R.A., and Wichern D.W. Applied multivariate statistical analysis. Fourth edition (1998), Prentice Hall, Upper Saddle River, New Jersey [428 pp]
29. Kirkegaard M., Sonne C., Leifsson P.S., Dieitz R., Born E.W., Letcher R.J., et al. Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants. Sci Total Environ 341 (2005) 119-132
30. Koeman J.H., and Van de Ven W.S. Mercury and selenium in marine mammals and birds. Sci Total Environ 3 (1975) 279-287
31. Koeman J.H., Peeters W.H.M., and Koudstaal-Hol C.H.M. Mercury-selenium correlations in marine mammals. Nature 245 (1973) 271-274
32. Krone C.A., Robisch P.A., Tilbury K.L., Stein J.E., Mackey E.A., Becker P.R., et al. Elements in liver tissues of bowhead whales (Balaena mysticetus). Mar Mamm Sci 15 (1999) 123-142
33. Lowry LF. Foods and feeding ecolgy. In Burns, J.J., Montague, J.J., Cowles, C.J., editors. The Bowhead Whale. Special Publication Number 2 The Society for Marine Mammalogy. Lawrence, KS Allen Press, Inc. 1993; pp. 701-744.
34. Lubetkin S., Zeh J., Rosa C., and George J.C. Deriving von Bertalanffy age-length relationships for bowhead whales using a synthesis of aging techniques (2004) [Paper SC/56/BRG3 presented to the IWC SC, June 2004]
35. Mackey E.A., Becker P.R., Demiralp R., Greenberg R.R., Koster B.J., and Wise S.A. Bioaccumulation of vanadium and other trace metals in livers of Alaskan cetaceans and pinnipeds. Arch Environ Contam Toxicol 30 (1996) 503-512
36. Milton J.S., and Arnold J. Introduction to probability and statistics. Third edition (1995), McGraw-Hill, New York, New York [228 pp]
37. Muir D.C.G., Wagemannn R., Hargrave B.T., Thomas D.J., Peakall D.B., and Norstrom R.J. Arctic marine ecosystem contamination. Sci Total Environ 122 (1992) 75-134
38. Muir D., Braune B., DeMarch B., Norstrom R., Wagemannn R., Lockhart L., et al. Spatial and temporal trends and effects of contaminants in the Canadian Arctic marine ecosystem: a review. Sci Total Environ 230 (1999) 83-144
39. Norstrom R.J., Schweinsburg R.E., and Collins B.T. Heavy metals and essential elements in livers of the polar bear (Ursus maritimus) n the Canadian arctic. Sci Total Environ 48 (1986) 195-212
40. O'Hara T., and O'Shea T.J. In: Reynolds J.E., and Rommel S.A. (Eds). Biology of Marine Mammals (2002), Smithsonin Books, Washington, D.C. [578 pp]
41. O'Hara T.M., George J.C., Tarpley R.J., Burek K., and Suydam R.S. Sexual maturation in male bowhead whales (Balaena mysticetus) of the Bering-Chukchi-Beaufort Seas stock. J Cetacean Res Manag 4 (2002) 143-148
42. O'Shea T.J., and Brownell R.L. Organochlorine and metal contaminants in baleen whales: a review and evaluation of conservation implications. Sci Total Environ 154 (1994) 179-200
43. Percy C., Pat B., Poronnik P., and Gobe G. Role of oxidative stress in age-associated chronic kidney pathologies. Adv Chromatogr Kid Dis 12 (2005) 78-83
44. Puls R. Mineral levels in animal health: Diagnostic data. 2nd edition (1994), Sherpa International Clearbrook, British Columbia, Canada [223 pp]
45. Rawson A.J., Bradley J.P., Teetsov A., Rice S.B., Haller E., and Patton G.W. A role for airborne particulates in high mercury levels of some cetaceans. Ecotoxicol Environ Saf 30 (1995) 309-314
46. Rosa C. Health assessment in the bowhead whale. Thesis, University of Alaska Fairbanks. 2006. 262 pp.
47. Rosa C., George J.C., Zeh J., Botta O., Zauscher M., Bada J., et al. Update on age estimation of bowhead whales (Balaena mysticetus) using aspartic acid racemization (2004) [Paper SC/56/BRG6 presented to the IWC SC, June 2004]
48. Sasaki T., Nikaido M., Hamilton H., Goto M., Kato H., Kanda N., et al. Mitochondrial phylogenetics and evolution of mysticete whales. Syst Biol 54 (2005) 77-90
49. Skaare J.U. Environmental pollutants in marine mammals from the Norwegian coast and Arctic. Sci Total Environ 186 (1996) 25-27
50. Sonne-Hansen C., Dietz R., Leifsson P.S., Hyldstrup L., and Riget F.F. Cadmium toxicity to ringed seals (Phoca hispida): an epidemiological study of possible cadmium-induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from Qaanaaq in Northwest Greenland. Sci Total Environ 295 (2002) 167-181
51. Sonne C., Dietz R., Leifsson P.S., Born E.W., Kirkegaard M., Riget F.F., et al. Do Organohalogen Contaminants Contribute to Liver Histopathology in East Greenland Polar Bears (Ursus maritimus)?. Environ Health Perspect 113 (2005) 1569-1574
52. Sonne C., Dietz R., Leiffson P.S., Born E.W., Kirkegaard M., and Riget E.F. Are liver and renal lesions in East Greenland polar bears (Ursus maritimus) associated with high mercury levels?. Environ Health 6 (2007) 11
53. Spears J.W. Trace mineral bioavailability in ruminants. J Nutr 133 (2003) 1506S-1509S
54. Stine, K.E., Brown, T.M., editors. Principles of Toxicology. CRC Press, Inc., Lewis Publishers, Boca Raton, Florida, USA, 1996, 259 pp.
55. Stirling I., Lunn N.J., and Iacozza J. Long-term trends in the population ecology of polar bears in western Hudson Bay in relation to climatic change. Arctic 52 (1999) 294
56. Takaki A., Jimi S., Segawa M., Hisano S., Takebayashi S., and Iwasaki H. Long-term cadmium exposure accelerates age-related mitochondrial changes in renal epithelial cells. Toxicology 203 (2004) 145-154
57. Tarpley R.J., and Hillmann D.J. Observations on ovary morphology, fetal size and functional correlates in the bowhead whale (Balaena mysticetus). A final report to the Department of Wildlife Management (1999), North Slope Borough, Barrow, AK
58. Teigen S.W., Andersen R.A., Daae H.L., and Skaare J.U. Heavy metal content in liver and kidneys of grey seals (Halichoerus grypus) in various life stages correlated with metallothionein levels: some metal binding characteristics of this protein. Environ Toxicol Chem 18 (1999) 2364-2369
59. ter Braak C.J. Cannonical correspondence analysis: a new eigenvector technique for multivariate direct gradient analysis. Ecology 67 (1986) 1167-1179
60. ter Braak C.J. Cannonical community ordination. Part I: basic theory and linear methods. Ecoscience 1 (1994) 127-140
61. ter Braak C.J. Ordination. In: Jongman R.H., ter Braak C.J., and Van Tongeren O.F. (Eds). Data analysis in community and landscape ecology (1995), Cambridge University, Cambridge, UK 91-173
62. ter Braak C.J., and Smilauer P. CANOCO reference manual and user's guide to CANOCO for windows: software for canonical community ordination (version 4). Microcomputer Power (1998), Ithaca, New York, New York, USA [245 pp]
63. Van Metre D.C., and Callan R.J. Selenium and vitamin E. Vet Clin North Am, Food Anim Pract 17 (2001) 373-402
64. Wagemann R., and Stewart R.E.A. Concentrations of heavy metals and selenium in tissues and some foods of walrus (Odobenus rosmarus rosmarus) from the Eastern Canadian Arctic and Sub-Arctic, and associations between metals, age and gender. Can J Fish Aquat Sci 51 (1994) 426-436
65. Wagemannn R., Hunt R., and Klaverkamp J.F. Subcellular distribution of heavy metals in liver and kidney of a narwhale (Monodon monoceros): an evaluation for the presence of metallothionein. Comp Biochem Physiol, Part C Comp Pharm Toxicol 78 (1984) 301-307
66. Wagemannn R., Innes S., and Richard P.R. Overview and regional and temporal differences of heavy metals in Arctic whales and ringed seals in the Canadian Arctic. Sci Total Environ 186 1,2 (1996) 41-66
67. Wagemannn R., Trebacz E., Boila G., and Lockhart W.L. Methylmercury and total mercury in tissues of arctic marine mammals. Sci Total Environ 218 (1998) 19-31
68. Wichtel J.J. A review of selenium deficiency in grazing ruminants. Part 1: new roles for selenium in ruminant metabolism. N Z Vet J 46 (1998) 47-52
69. Woshner V. Concentrations and interactions of selected elements in tissues of four marine mammal species harvested by Inuit hunters with an intensive histological assessment emphasizing the beluga whale. Thesis, University of Illinois, Urbana-Champaign. 2000. 302 pp.
70. Woshner V.M., O'Hara T.M., Bratton G.R., Suydam R.S., and Beasley V.R. Concentrations and interactions of selected essential and non-essential elements in bowhead and beluga whales of arctic Alaska. J Wildl Dis 37 (2001) 693-710
71. Woshner V.M., O'Hara T.M., Eurell J.A., Wallig M.A., Bratton G.R., Suydam R.S., et al. Distribution of inorganic mercury in liver and kidney of beluga and bowhead whales through autometallographic development of light microscopic tissue sections. Toxicol Pathol 30 (2002) 209-215