Growth factors, muscle function and doping

Current Opinion in Pharmacology

Volumn 8, Issue 3, 2008, Pages 352-357

  Goldspink, Geoffrey ^a   Wessner, Barbara ^b   Bachl, Norbert ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Centre for Sports Sciences   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; GROWTH FACTOR; HUMAN GROWTH HORMONE; ISOPROTEIN; MECHANO GROWTH FACTOR; PROGESTERONE; SOMATOMEDIN C; SOMATOMEDIN C DERIVATIVE; TESTOSTERONE; VIRUS VECTOR;

AGING; BODY BUILDING; CELL NUCLEUS; DOPING; GENE ACTIVATION; HUMAN; MUSCLE; MUSCLE ATROPHY; MUSCLE FUNCTION; MUSCLE HYPERTROPHY; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN VARIANT; REVIEW; RNA SPLICING; SOCIAL PROBLEM; STEM CELL; TISSUE REPAIR;

ANDROGENS; ANIMALS; DOPING IN SPORTS; GENE THERAPY; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MUSCLE PROTEINS; MUSCLE STRENGTH; MUSCLE, SKELETAL; TRANSFORMING GROWTH FACTOR BETA; WASTING SYNDROME;

EID: 44649085754     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2008.02.002     Document Type: Review

References (39)

1. Griffin G.E., and Goldspink G. The increase in skeletal muscle mass in male and female mice. Anat Rec 177 (1973) 465-469
2. McPherron A.C., and Lee S.J. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A 94 (1997) 12457-12461
3. Schuelke M., Wagner K.R., Stolz L.E., Hübner C., Riebel T., Kömen W., Braun T., Tobin J.F., and Lee S.J. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 350 (2004) 2682-2688
4. McMahon C.D., Popovic L., Oldham J.M., Jeanplong F., Smith H.K., Kambadur R., Sharma M., Maxwell L., and Bass J.J. Myostatin-deficient mice lose more skeletal muscle mass than wild type controls during hind limb suspension. Am J Physiol Endocrinol Metab 285 (2003) E82-E87
5. Grobet L., Pirottin D., Farnir F., Poncelet D., Royo L.J., Brouwers B., Christians E., Desmecht D., Coignoul F., Kahn R., and Georges M. Modulating skeletal muscle mass by postnatal, muscle specific inactivation of the myostatin gene. Genesis 35 (2003) 227-238
6. Amthor H., Otto A., Macharia R., McKinnell I., and Patel K. Myostatin imposes reversible quiescence on embryonic muscle precursors. Dev Dyn 235 (2006) 672-680
7. Amthor H., Macharia R., Navarrete R., Schuelke M., Brown S.C., Otto A., Voit T., Muntoni F., Vrbóva G., Partridge T., et al. Lack of myostatin results in excessive muscle growth but impaired force generation. Proc Natl Acad Sci U S A 104 (2007) 1835-1840. This study revealed that mice deficient in myostatin showed no increase in maximum tetanic force generation despite a larger muscle mass relative to age-matched wild types.
8. Arthur P.F. Double muscling in cattle: a review. Aust J Agric Res 46 (1995) 1493-1515
9. Goldspink D.F., and Goldspink G. Age-related changes in protein turnover and ribonucleic acid of the diaphragm muscle of normal and a dystrophic hamsters. Biochem J 162 (1977) 191-194
10. Sacheck J.M., Ohtsuka A., McLary S.C., and Goldberg A.L. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 287 (2004) E591-E601
11. Latres E., Amini A.R., Amini A.A., Griffiths J., Martin F.J., Wei Y., Lin H.C., Yancopoulos G.D., and Glass D.J. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 280 (2005) 2737-2744
12. Sjögren K., Liu J.L., Blad K., Skrtic S., Vidal O., Wallenius V., LeRoith D., Törnell J., Isaksson O.G., Jansson J.O., and Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci U S A 96 (1999) 7088-7092
13. Yakar S., Liu J.L., Stannard B., Butler A., Accili D., Sauer B., and LeRoith D. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A 96 (1999) 7324-7329
14. Rudman D., Kutner M.H., Rogers C.M., Lubin M.F., Fleming G.A., and Bain R.P. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 67 (1981) 1361-1369
15. Cuneo R.C., Salomon F., Wiles C.M., Hesp R., and Sonksen P.H. Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol 70 (1991) 688-694
16. Beshyah S.A., Freemantle C., Shahi M., Anyaoku V., Merson S., Lynch S., Skinner E., Sharp P., Foale R., and Johnston D.G. Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults. Clin Endocrinol (Oxf) 42 (1995) 73-84
17. Spangenburg E.E., Le Roith D., Ward C.W., and Bodine S.C. A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol 586 (2008) 283-291
18. Yang S., Alnaqeeb M., Simpson H., and Goldspink G. Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. J Muscle Res Cell Motil 17 (1996) 487-495
19. McKoy G., Ashley W., Mander J., Yang S.Y., Williams N., Russell B., and Goldspink G. Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. J Physiol 516 (1999) 583-592
20. Goldspink G., and Yang S.Y. The splicing of the IGF-I gene to yield different muscle growth factors. Adv Genet 52 (2004) 23-49
21. Hameed M., Lange K.H., Andersen J.L., Schjerling P., Kjaer M., Harridge S.D., and Goldspink G. The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. J Physiol 555 (2004) 231-240
22. Haddad F., and Adams G.R. Selected contribution: acute cellular and molecular responses to resistance exercise. J Appl Physiol 93 (2002) 394-403
23. Hill M., and Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 549 (2003) 409-418
24. Yang S.Y., and Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 522 (2002) 156-160
25. Ates K., Yang S.Y., Orrell R.W., Sinanan A.C., Simons P., Solomon A., Beech S., Goldspink G., and Lewis M.P. IGF-I Splice variant (MGF) increases progenitor cells in ALS, dystrophic and normal muscle. FEBS Lett 581 (2007) 2727-2732. In human primary muscle cell cultures derived from healthy subjects as well as from muscular dystrophy and ALS patients the E domain peptide of IGF-IEc was able to enhance progenitor cells while blocking differentiation.
26. Mauro A. Satellite cells of skeletal muscle fibres. J Biophys Biochem Cytol 9 (1961) 493-495
27. Moss F.P., and Leblond C.P. Satellite cells are the source of nuclei in muscles of growing rats. Anat Rec 170 (1970) 421-435
28. Jacquemin V., Furling D., Bigot A., Butler-Browne G.S., and Mouly V. IGF-1 induces human myotube hypertrophy by increasing cell recruitment. Exp Cell Res 299 (2004) 148-158
29. Shavlakadze T., Davies M., White J.D., and Grounds M.D. Early regeneration of whole skeletal muscle grafts is unaffected by overexpression of IGF-1 in MLC/mIGF-1 transgenic mice. J Histochem Cytochem 52 (2004) 873-881
30. Hameed M., Orrell R.W., Cobbold M., Goldspink G., and Harridge S.D. Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol 547 (2003) 247-254
31. Owino V., Yang S.Y., and Goldspink G. Age-related loss of skeletal muscle functionand the inability to express the autocrine form of insulin-like growth factor-I (MGF) in response to mechanical overload. FEBS Lett 506 (2001) 259-262
32. Brooks S.V., and Faulkner J.A. Severity of contraction-induced injury is affected by velocity only during stretches of large strain. J Appl Physiol 91 (2001) 661-666
33. Goldspink G., Yang S.Y., Skarli M., and Vrbova G. Local growth regulation is associated with an isoform of IGF-I that is expressed in normal muscles but not in dystrophic muscles. J Physiol 495 (1996) 162-163
34. De Bari C., Dell'Accio F., Vandenbeele F., Vermeesch J.R., Raymackers J.-M., and Luyten F.P. Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane. Cell Biol 160 (2003) 909-918
35. Barton E.R. Viral expression of insulin-like growth factor-1 isoforms promotes different responses in skeletal muscle. J Appl Physiol 100 (2006) 1778-1784. This study investigates effectiveness of viral-mediated delivery of murine IGF-IB and IGF-IA to the skeletal muscle of young and old mice.
36. Goldspink G, Goldspink PH, Yang SY: US patent MGF E peptides filed March 20th 2006 published on line by US patent Office September 21st 2006.
37. Shioura K.M., Los T., Greenen D.I., Goldspink G., and Goldspink P.H. The unique E-domain of an IGF-I isoform expressed in muscle preserves cardiac function and prevents apopotosis following cardiac infarction. Circulation 114 (2006) 232-233
38. Carpenter V., Matthews K., Devlin G., Stuart S., Jensen J., Conaglen J., Jeanplong F., Goldspink P., Yang S.Y., Goldspink G., et al. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ 17 (2008) 33-39. The authors investigated whether MGF would reduce the area of 'at-risk' myocardium and improve cardiac function in the post-infarct heart of sheep.
39. Conboy I.M., and Rando T.A. The regulation of Notch signalling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell 3 (2002) 397-409