Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail

Peptides

Volumn 29, Issue 7, 2008, Pages 1167-1175

  Mitselos, Anna ^a   Peeters, Theo L ^a   Depoortere, Inge ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

C terminal truncation; Ca2+ luminescence; Desensitization; Internalization; Motilin receptor; Motilin receptor mutants; Phosphorylation

Indexed keywords

AEQUORIN; AMINO ACID; CALCIUM; GREEN FLUORESCENT PROTEIN; MOTILIN; MOTILIN RECEPTOR; MUTANT PROTEIN; NEUROPEPTIDE RECEPTOR;

ARTICLE; BINDING AFFINITY; CELL SURFACE; CELL VACUOLE; CONTROLLED STUDY; DESENSITIZATION; FLUORESCENCE MICROSCOPY; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AEQUORIN; AMINO ACID SEQUENCE; ANIMALS; APOPROTEINS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL AGENTS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT MEASUREMENTS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MOTILIN; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN;

EID: 44649084226     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.02.023     Document Type: Article

References (35)

1. Bhatnagar A., Willins D.L., Gray J.A., Woods J., Benovic J.L., and Roth B.L. The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J Biol Chem 276 (2001) 8269-8277
2. Chen C.Y., Dion S.B., Kim C.M., and Benovic J.L. Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation. J Biol Chem 268 (1993) 7825-7831
3. Christofides N.D., Modlin I.M., Fitzpatrick M.L., and Bloom S.R. Effect of motilin on the rate of gastric emptying and gut hormone release during breakfast. Gastroenterology 76 (1979) 903-907
4. Diviani D., Lattion A.L., and Cotecchia S. Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor. J Biol Chem 272 (1997) 28712-28719
5. Duvernay M.T., Zhou F., and Wu G. A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface. J Biol Chem 279 (2004) 30741-30750
6. Falquet L., Pagni M., Bucher P., Hulo N., Sigrist C.J., Hofmann K., et al. The PROSITE database, its status in 2002. Nucleic Acids Res 30 (2002) 235-238
7. Ferguson S.S. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53 (2001) 1-24
8. Gabilondo A.M., Hegler J., Krasel C., Boivin-Jahns V., Hein L., and Lohse M.J. A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalisation. Proc Natl Acad Sci USA 94 (1997) 12285-12290
9. Gray J.A., Sheffler D.J., Bhatnagar A., Woods J.A., Hufeisen S.J., Benovic J.L., et al. Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells. Mol Pharmacol 60 (2001) 1020-1030
10. Gurevich V.V., and Gurevich E.V. The molecular acrobatics of arrestin activation. Trends Pharmacol Sci 25 (2004) 105-111
11. Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., and Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77 (1989) 51-59
12. Itoh Z., Honda R., Hiwatashi K., Takeuchi S., Aizawa I., Takayanagi R., et al. Motilin induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol Suppl 39 (1976) 93-110
13. Jala V.R., Shao W.H., and Haribabu B. Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. J Biol Chem 280 (2005) 4880-4887
14. Janssens J., Peeters T.L., Vantrappen G., Tack J., Urbain J.L., De Roo M., et al. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. Preliminary studies. N Engl J Med 322 (1990) 1028-1031
15. Kim S.J., Kim M.Y., Lee E.J., Ahn Y.S., and Baik J.H. Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor. Mol Endocrinol 18 (2004) 640-652
16. Kishi H., Krishnamurthy H., Galet C., Bhaskaran R.S., and Ascoli M. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion. J Biol Chem 277 (2002) 21939-21946
17. Lattion A.L., Diviani D., and Cotecchia S. Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor. J Biol Chem 269 (1994) 22887-22893
18. Marion S., Oakley R.H., Kim K.M., Caron M.G., and Barak L.S. A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J Biol Chem 281 (2006) 2932-2938
19. Min L., Galet C., and Ascoli M. The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation. J Biol Chem 277 (2002) 702-710
20. Mitselos A., Vanden Berghe P., Peeters T., and Depoortere I. Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking. Biochem Pharmacol 75 (2008) 1115-1128
21. Mitselos A., Depoortere I., and Peeters T.L. Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists. Biochem Pharmacol 73 (2007) 115-124
22. Murray S.R., Evans C.J., and von Zastrow M. Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor. J Biol Chem 273 (1998) 24987-24991
23. Omura S., Tsuzuki K., Sunazuka T., Marui S., Toyoda H., Inatomi N., et al. Macrolides with gastrointestinal motor stimulating activity. J Med Chem 30 (1987) 1941-1943
24. Onorato J.J., Palczewski K., Regan J.W., Caron M.G., Lefkowitz R.J., and Benovic J.L. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30 (1991) 5118-5125
25. Peeters T., Matthijs G., Depoortere I., Cachet T., Hoogmartens J., and Vantrappen G. Erythromycin is a motilin receptor agonist. Am J Physiol 257 (1989) G470-G474
26. Peeters T.L., Muls E., Janssens J., Urbain J.L., Bex M., Van Cutsem E., et al. Effect of motilin on gastric emptying in patients with diabetic gastroparesis. Gastroenterology 102 (1992) 97-101
27. Preisser L., Ancellin N., Michaelis L., Creminon C., Morel A., and Corman B. Role of the carboxyl-terminal region, di-leucine motif and cysteine residues in signalling and internalization of vasopressin V1a receptor. FEBS Lett 460 (1999) 303-308
28. Richardson M.D., Balius A.M., Yamaguchi K., Freilich E.R., Barak L.S., and Kwatra M.M. Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. J Neurochem 84 (2003) 854-863
29. Schulein R., Hermosilla R., Oksche A., Dehe M., Wiesner B., Krause G., et al. A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS M6 cells. Mol Pharmacol 54 (1998) 525-535
30. Tack J., and Peeters T. What comes after macrolides and other motilin stimulants?. Gut 49 (2001) 317-318
31. Thielemans L., Depoortere I., Perret J., Robberecht P., Liu Y., Thijs T., et al. Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther 313 (2005) 1397-1405
32. Tokunaga H., Matsuura B., Dong M., Miller L.J., Ueda T., Furukawa S., et al. Mutational analysis of the predicted intracellular loop domains of the human motilin receptor. Am J Physiol Gastrointest Liver Physiol (2007)
33. Vantrappen G., Janssens J., Peeters T.L., Bloom S.R., Christofides N.D., and Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci 24 (1979) 497-500
34. Wang W., Loh H.H., and Law P.Y. The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells. J Biol Chem 278 (2003) 36848-36858
35. Widmann C., Dolci W., and Thorens B. Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites. Mol Endocrinol 11 (1997) 1094-1102