Formulation of monolayered films with drug and polymers of opposing solubilities

International Journal of Pharmaceutics

Volumn 358, Issue 1-2, 2008, Pages 184-191

  Perumal, V A ^a   Lutchman, D ^b   Mackraj, I ^a   Govender, T ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Buccal; Drug release; Films; Physicochemical mechanical characterisation

Indexed keywords

CHITOSAN; EUDRAGIT; POLYMER; PROPRANOLOL; SILICONE;

ARTICLE; BUCCAL DRUG ADMINISTRATION; CONTROLLED DRUG RELEASE; DRUG SOLUBILITY; ELASTICITY; EMULSION; ENERGY; FILM; HYDROPHILICITY; MOLECULAR MECHANICS; PRIORITY JOURNAL; STATISTICAL ANALYSIS; THICKNESS;

ACRYLIC RESINS; ADRENERGIC BETA-ANTAGONISTS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG COMPOUNDING; EXCIPIENTS; HALF-LIFE; HARDNESS; HYDROGEN-ION CONCENTRATION; KINETICS; PHARMACEUTICAL PREPARATIONS; PROPRANOLOL; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SURFACE PROPERTIES; TISSUE ADHESIVES;

EID: 44449179705     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.03.005     Document Type: Article

References (26)

1. Ahmed A., Barry B.W., Williams A.C., and Davis A.F. Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques. J. Pharm. Biomed. Anal. 34 (2004) 945-956
2. Akhgari A., Faramand F., Garekani H.A., Sadeghi F., and Vandamme T.F. Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery. Eur. J. Pharm. Sci. 28 (2006) 307-314
3. Amnuaikit C., Ikeuchi I., Ogawara K., Higaki K., and Kimura T. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. Int. J. Pharm. 289 (2005) 167-178
4. Bottenberg P., Cleymaet R., Muynck C.D., Renon J., Coomans D., and Slop Y. Development and testing of bioadhesive, fluoride-containing slow release tablets for oral use. J. Pharm. Pharmacol. 43 (1991) 457-464
5. Bromberg L.E., Buxton D.K., and Friden P.M. Novel periodontal drug delivery system for the treatment of periodontitis. J. Control. Release 71 (2001) 251-259
6. British Pharmacopoeia III. Her Majesty's (2003), Stationery Office Ltd., London pp. 2598-2599
7. Dhanikula A.B., and Panchagnula R. Development and characterisation of biodegradable chitosan films for local delivery of paclitaxel. AAPS J. 3 (2004) 1-12
8. Eouani C., Piccerelle P., Prinderre P., Bouret E., and Jaochim J. In vitro comparative study of buccal mucoadhesive performance of different polymeric films. Eur. J. Pharm. Biopharm. 52 (2001) 45-55
9. Gomeni R., Bianchetti G., Sega R., and Morselli P.L. Pharmacokinetics of propranolol in normal healthy volunteers. J. Pharmacokinet. Biopharm. 5 (1997) 183-191
10. Heng P.W.S., Chan L.W., and Ong K.T. Influence of storage conditions and type of plasticisers on ethylcellulose and acrylate films formed from aqueous dispersions. J. Pharm. Pharm. Sci. 6 (2003) 334-344
11. Huntsberger J.R. The mechanisms of adhesion. In: Patrick R.L. (Ed). Treatise on Adhesion and Adhesives (1967), Marcel Dekker, New York 119-149
12. Munasur A., Pillay V., Chetty D.J., and Govender T. Statistical optimisation of the mucoadhesivity and characterization of multipolymeric propranolol matrices for buccal therapy. Int. J. Pharm. 323 (2006) 43-51
13. Nigalaye A.G., Adusumilli P., and Bolton S. Investigation of prolonged drug release from matrix formulations of chitosan. Drug Dev. Ind. Pharm. 16 (1990) 449-467
14. Nunthanid J., Puttipipatkhachorn S., Yamamoto K., and Peck G.E. Physical properties and molecular behaviour of chitosan films. Drug Dev. Ind. Pharm. 27 (2001) 143-157
15. Padula C., Colombo G., Nicoli S., Luigi P., Massimo G., and Santi P. Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behaviour. J. Control. Release 88 (2003) 277-285
16. Peh K.K., and Wong C.F. Polymeric films as vehicles for buccal delivery: swelling, mechanical and bioadhesive properties. J. Pharm. Pharm. Sci. 2 (1999) 53-61
17. Perioli L., Ambrogi V., Angelici F., Ricci M., Giovagnoli S., Capuccella M., and Rossi C. Development of mucoadhesive patches for buccal administration of ibuprofen. J. Control. Release 99 (2004) 73-82
18. Perugini P., Genta I., Conti B., Modena T., and Pavanetto F. Periodontal delivery of ipriflavone: new chitosan/PLGA film delivery system for lipophilic drug. Int. J. Pharm. 252 (2003) 1-9
19. Perumal, V.A., Lutchman, D., Mackraj, I., Govender, T., in press. Investigating a new approach to film casting for enhanced drug content uniformity in polymeric films. Drug Dev. Ind. Pharm. (Ref: UT2007-344) and Manuscript ID: 293061.
20. Remunan-Lopez C., Portero A., Vila-Jato J.L., and Alonso M.J. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J. Control. Release 55 (1998) 143-152
21. Salomon G. Adhesives. In: Houwink R., and Salomon G. (Eds). Adhesion and Adhesives (1970), Elsevier Publishers, New York 1-140
22. Senel S., Ikinci G., Kas S., Yousefi-Rad A., Sargon M.F., and Hincal A.A. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int. J. Pharm. 193 (2000) 197-203
23. Wang Y., Challa P., Epstein D.L., and Yuan F. Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. Biomaterials 25 (2004) 4279-4285
24. Woolfson A.D., McCafferty D.F., McCarron P.A., and Price J.H. A bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue. J. Control. Release 35 (1995) 49-58
25. Yang, R.K., Fuisz, R.C., Myers, G.L., Fuisz, J.M., 2004. Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom, US Patent 60/443,741.
26. Yoo J.W., Dharmala K., and Lee C.H. The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Int. J. Pharm. 309 (2006) 139-145