The Src-like adaptor protein regulates PDGF-induced actin dorsal ruffles in a c-Cbl-dependent manner

Oncogene

Volumn 27, Issue 24, 2008, Pages 3494-3500

  Sirvent, A ^a   Leroy, C ^a   Boureux, A ^a,b   Simon, V ^a   Roche, S ^a  

^a Centre National de la Recherche Scientifique   (France)

^b INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

Cbl; DNA synthesis; F actin assembly; PDGF; SLAP; Src

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; ADAPTOR PROTEIN; CBL PROTEIN; F ACTIN; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SRC LIKE ADAPTOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL INVASION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA SYNTHESIS; DRUG INHIBITION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ACTINS; ANIMALS; BINDING, COMPETITIVE; FIBROBLASTS; LUNG; MICE; MITOSIS; NIH 3T3 CELLS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RAC GTP-BINDING PROTEINS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 44449169867     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1211011     Document Type: Article

References (19)

1. Boureux A, Furstoss O, Simon V, Roche S. (2005). c-Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and c-myc expression induced by growth factors. 118: 3717-3726.
2. Bromann PA, Korkaya H, Courtneidge SA. (2004). The interplay between Src family kinases and receptor tyrosine kinases. Oncogene 23: 7957-7968.
3. Broome MA, Galisteo ML, Schlessinger J, Courtneidge SA. (1999). The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases. Oncogene 18: 2908-2912.
4. Ishizawar R, Parsons SJ. (2004). c-Src and cooperating partners in human cancer. Cancer Cell 6: 209-214.
5. Lanzetti L, Palamidessi A, Areces L, Scita G, Di Fiore PP. (2004). Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 429: 309-314.
6. Manes G, Bello P, Roche S. (2000). Slap inhibits the Src-mitogenic function but does not affect Src-induced cell transformation. Mol Cell Biol 20: 3396-3406.
7. Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H. (1999). Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem 274: 16619-16628.
8. Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H et al. (2006). Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol 7: 57-66.
9. Pandey A, Duan H, Dixit VM. (1995). Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem 270: 19201-19204.
10. Reddi AL, Ying G, Duan L, Chen G, Dimri M, Douillard P et al. (2007). Binding of Cbl to a PLCgamma 1-docking site on PDGFRbeta provides a dual mechanism of negative regulation. J Biol Chem 282: 29336-29347.
11. Roche S, Alonso G, Kazlauskas A, Dixit VM, Courtneidge SA, Pandey A. (1998a). Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr Biol 8: 975-978.
12. Roche S, Downward J, Raynal P, Courtneidge SA. (1998b). A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol Cell Biol 18: 7119-7129.
13. Scaife RM, Courtneidge SA, Langdon WY. (2003). The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly. J Cell Sci 116: 463-473.
14. Schmidt MH, Dikic I. (2005). The Cbl interactome and its functions. Nat Rev Mol Cell Biol 6: 907-919.
15. Sosinowski T, Killeen N, Weiss A. (2001). The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity 15: 457-466.
16. Suetsugu S, Yamazaki D, Kurisu S, Takenawa T. (2003). Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev Cell 5: 595-609.
17. Swaminathan G, Feshchenko EA, Tsygankov AY. (2007). c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl. Oncogene 26: 4095-4105.
18. Teckchandani AM, Panetti TS, Tsygankov AY. (2005). c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1. Exp Cell Res 307: 247-258.
19. Veracini L, Franco M, Boureux A, Simon V, Roche S, Benistant C. (2006). Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. J Cell Sci 20: 2921-2934.