Part II: Fibroblasts preferentially migrate in the direction of principal strain

Biomechanics and Modeling in Mechanobiology

Volumn 7, Issue 3, 2008, Pages 215-225

  Raeber, G P ^a   Lutolf, M P ^a   Hubbell, J A ^a  

^a EPFL   (Switzerland)

Author keywords

Cell migration; Local effective stiffness; Mechanical stimulation; PEG hydrogels

Indexed keywords

CELL ADHESION; CELL GROWTH; CYCLIC LOADS; ENZYME ACTIVITY; HYDROGELS; PARAMETER ESTIMATION; POLYETHYLENE GLYCOLS; STIFFNESS;

CELL MIGRATION; LOCAL EFFECTIVE STIFFNESS; MECHANICAL STIMULATION; PEG HYDROGELS;

FIBROBLASTS;

ARTICLE; BIOMECHANICS; CELL CULTURE; CELL MOTION; CELL POLARITY; CYTOLOGY; FIBROBLAST; HUMAN; TIME;

BIOMECHANICS; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; FIBROBLASTS; HUMANS; TIME FACTORS;

EID: 44449167178     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-007-0090-1     Document Type: Article

References (46)

1. Balaban NQ, Schwarz US, Riveline D, Goichberg P, Tzur G, Sabanay I, Mahalu D, Safran S, Bershadsky A, Addadi L, Geiger B (2001) Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates. Nat Cell Biol 3:466-472
2. Bray D (1984) Axonal growth in response to experimentally applied mechanical tension. Dev Biol 102:379-389
3. Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes RT, Stetler-Stevenson WG, Quigley JP, Cheresh DA (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85:683-693
4. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE (1997) Geometric control of cell life and death. Science 276:1425-1428
5. Choquet D, Felsenfeld DP, Sheetz MP (1997) Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 88:39-48
6. Cukierman E, Pankov R, Stevens DR, Yamada KM (2001) Taking cell-matrix adhesions to the third dimension. Science 294:1708-1712
7. Cukierman E, Pankov R, Yamada KM (2002) Cell interactions with three-dimensional matrices. Curr Opin Cell Biol 14:633-639
8. Dickinson RB, Tranquillo RT (1993) Optimal estimation of cell movement indices from the statistical analysis of cell tracking data. AIChE J 39:1995-2010
9. Duncan R, Turner C (1995) Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57:344-358
10. Engler AJ, Sen S, Sweeney HL, Discher DE (2006) Matrix elasticity directs stem cell lineage specification. Cell 126:677-698
11. Geiger B, Bershadsky A (2001) Assembly and mechanosensory function of focal contacts. Curr Opin Cell Biol 13:584-592
12. Goldmann WH (2002) Mechanical aspects of cell shape regulation and signaling. Cell Biol Int 26:313-317
13. Henderson JH, Carter DR (2002) Mechanical induction in limb morphogenesis: the role of growth-generated strains and pressures. Bone 31:645-653
14. Hern DL, Hubbell JA (1998) Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res 39:266-276
15. Ingber DE (1997) Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol 59:575-599
16. Ingber DE (2002) Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circ Res 91:877-887
17. Katsumi A, Orr AW, Tzima E, Schwartz MA (2004) Integrins in mechanotransduction. J Biol Chem 279:12001-12004
18. Katz BZ, Zamir E, Bershadsky A, Kam Z, Yamada KM, Geiger B (2000) Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. Mol Biol Cell 11:1047-1060
19. Knapp DM, Barocas VH, Moon AG, Yoo K, Petzold LR, Tranquillo RT (1997) Rheology of reconstituted type I collagen gel in confined compression. J Rheol 41:971-993
20. Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG (2002) Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci 115:1423-1433
21. Korff T, Augustin HG (1999) Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci 112:3249-3258
22. Li C, Wernig F, Leitges M, Hu Y, Xu Q (2003) Mechanical stress-activated PKCdelta regulates smooth muscle cell migration. FASEB J 17:2106-2108
23. Lo CM, Wang HB, Dembo M, Wang YL (2000) Cell movement is guided by the rigidity of the substrate. Biophys J 79:144-152
24. Lutolf MP, Hubbell JA (2003) Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules 4:713-722
25. Lutolf MP, Hubbell JA (2005) Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 23:47-55
26. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA (2003a) Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc Natl Acad Sci USA 100:5413-5418
27. Lutolf MP, Raeber GP, Zisch AH, Tirelli N, Hubbell JA (2003b) Cell-responsive synthetic hydrogels. Adv Mater 15:888-892
28. Parker KK, Brock AL, Brangwynne C, Mannix RJ, Wang N, Ostuni E, Geisse NA, Adams JC, Whitesides GM, Ingber DE (2002) Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J 16:1195-1204
29. Parkhurst MR, Saltzman WM (1992) Quantification of human neutrophil motility in three-dimensional collagen gels. Effect of collagen concentration. Biophys J 61:306-315
30. Pedersen JA, Swartz MA (2005) Mechanobiology in the third dimension. Ann. Biomed. Eng. 33:1469-1490
31. Pierschbacher MD, Ruoslahti E (1984) Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30-33
32. Prajapati RT, Chavally-Mis B, Herbage D, Eastwood M, Brown RA (2000a) Mechanical loading regulates protease production by fibroblasts in three-dimensional collagen substrates. Wound Repair Regen 8:226-237
33. Prajapati RT, Eastwood M, Brown RA (2000b) Duration and orientation of mechanical loads determine fibroblast cyto-mechanical activation: monitored by protease release. Wound Repair Regen 8:238-246
34. Raeber GP, Mayer J, Hubbell JA (2007a) Part I: A novel in vitro system for simultaneous stimulation and time-lapse microscopy in 3D. Biomech. Model Mechanobiol (in press)
35. Raeber GP, Lutolf MP, Hubbell JA (2007b) Mechanisms of 3D migration and matrix remodeling of fibroblasts within artificial ECMs. Acta Biomater (in press)
36. Raeber GP, Lutolf MP, Hubbell JA (2005) Molecularly engineered PEG hydrogels: a novel model system for proteolytically-mediated cell migration. Biophys J 89:1374-1388
37. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD (2001) Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK- independent mechanism. J Cell Biol 153:1175-1186
38. Sachs F, Morris CE (1998) Mechanosensitive ion channels in nonspecialized cells. Rev Physiol Biochem Pharmacol 132:1-77
39. Shreiber DI, Barocas VH, Tranquillo RT (2003) Temporal variations in cell migration and traction during fibroblast-mediated gel compaction. Biophys J 84:4102-4114
40. Shyy JY, Chien S (1997) Role of integrins in cellular responses to mechanical stress and adhesion. Curr Opin Cell Biol 9:707-713
41. Takakuda K, Miyairi H (1996) Tensile behaviour of fibroblasts cultured in collagen gel. Biomaterials 17:1393-1397
42. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349-363
43. Van Essen DC (1997) A tension-based theory of morphogenesis and compact wiring in the central nervous system. Nature 385:313-318
44. von Offenberg Sweeney N, Cummins PM, Birney YA, Redmond EM, Cahill PA (2004) Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration. Biochem Biophys Res Commun 320:325-333
45. Wang N, Butler JP, Ingber DE (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science 260:1124-1127
46. Williams B (1998) Mechanical influences on vascular smooth muscle cell function. J Hypertens 16:1921-1929