Design considerations for a minimally invasive high-throughput automation system for radiation biodosimetry

Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007

Volumn , Issue , 2007, Pages 846-852

  Salerno, A ^a   Zhang, J ^a   Bhatla, A ^a   Lyulko, O V ^b   Nie, J ^b   Dutta, A ^b   Garty, G ^b   Simaan, N ^a   Randers Pehrson, G ^b   Yao, Y L ^a   Brenner, D J ^b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIQUID HANDLING MODULE; SYSTEM THROUGHPUT;

BIOASSAY; DOSIMETRY; IMAGE ACQUISITION; RADIOLOGY; ROBOTICS;

NONINVASIVE MEDICAL PROCEDURES;

EID: 44449166195     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/COASE.2007.4341709     Document Type: Conference Paper

References (20)

1. International Atomic Energy Agency, The radiological accident at Goiânia, ed. I.A.E.A. 1988, Vienna.
2. T.C. Pellmar and S. Rockwell, Priority list of research areas for radiological nuclear threat countermeasures. Radiation Research, 2005. 163: p. 115-123.
3. Meldrum, D.R., et al., Sample Preparation in Glass Capillaries for High-Throughput Biochemical Analyses, in International Conference on Automation Science and Engineering. 2005: Edmonton, Canada.
4. V. Kachel, G.Sindelar, and S. Grimm, High-throughput isolation of ultra-pure plasmid DNA by a robotic system. BMC Biotechnology, 2006. 6(9).
5. Prasanna, P.G.S., et al., Cytogenetic Biodosimetry for Radiation Disasters: Recent Advances. 2005, Technical Report. (AFRRI CD 05-2). Armed Forces Radiobiology Research Institute.
6. Soldatova, L.N., et al., An ontology for a robot scientist. Bioinformatics, 2006. 22(14): p. 464-471.
7. Hayata, I., et al., Robot system for preparing lymphocyte chromosome. J. Radiation Research, 1992. 33(Supplement): p. 231-241.
8. Amundson, S.A., et al., Biological indicators for the identification of ionizing radiation exposure in humans. Expert Rev. Mol. Diagn., 2001. 1: p. 211-219.
9. Durante, M., Potential applications of biomarkers of radiation exposure in nuclear terrorism events. Phisica Medica, 2003. XIX(3): p. 191-212.
10. M. Fenech and A.A. Morley, Measurement of Micronuclei in Lymphocytes. Mutation Research, 1985. 147(1-2): p. 29-36.
11. International Atomic Energy Agency, Cytogenetic analysis for radiation dose assessment : a manual, ed. I.A.E.A. 2001, Vienna. 127 p.
12. Bonassi, S., et al., An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis, 2007. 28(3): p. 625-631.
13. Livingston, G.K., et al., Radiobiological evaluation of immigrents from the vicinity of Chernobyl. International Journal of Radiation Biology, 1997. 72: p. 703-713.
14. da Cruz, A.D., et al., Human micronucleus counts are correlated with age, smoking and cesium-137 dose in the Goiânia (Brazil) radiological accident. Mutation Research, 1994(313): p. 57-68.
15. Rogakou, E.P., et al., DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139. J. Biol. Chem., 1998. 273(10): p. 5858-5868.
16. MacPhail, S., et al., Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. International Journal of Radiation Biology, 2003. 79(5): p. 351-358.
17. Rogakou, E.P., et al., Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol., 1999. 146: p. 905-916.
18. K. Rothkamm and M. Lobrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. USA, 2003. 100: p. 5057-5062.
19. Pilch, D.R., et al., Characteristics of gamma-H2AX foci at DNA double strand breaks sites. Biochemistry and cell biology, 2003. 81(3): p. 123-129.
20. J. P. Banath, S. H. Macphail, and P.L. Olive, Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Research, 2004. 64: p. 7144-7149.