Ascorbic acid augments the adenylyl cyclase-cAMP system mediated POMC mRNA expression and β-endorphin secretion from hypothalamic neurons in culture

Brain Research

Volumn 706, Issue 2, 1996, Pages 243-248

  Yang, Zhiyu ^a   Copolov, David L ^a   Lim, Alan T ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Adenylyl cyclase; Ascorbic acid; Ccll culture; Hypothalamus; Endorphin

Indexed keywords

ASCORBIC ACID; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PROOPIOMELANOCORTIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; HORMONE RELEASE; HYPOTHALAMUS; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030069045     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(95)01135-8     Document Type: Article

References (28)

1. +-dependent co-transport, J. Biol. Chem., 258 (1983) 12886-12894.
2. Eipper, B.A. and Mains, R.E., The role of ascorbate in the biosynthesis of neuroendocrine peptides, Am. J. Clin. Nutr., 54 (1991) 1153S-1156S.
3. Eipper, B.A., Mains, R.E. and Glembotski, C.C., Identification in pituitary tissue of a peptide α-amidation activity that acts on glycine-estended peptides and requires molecular oxygen, copper and ascorbic acid, Proc. Natl. Acad. Sci. USA, 80 (1983) 5144-5148.
4. Faivre, Bauman, A., Loudes, C., Barret, A., Patte, C. and Tixier, Vidal, A., Ontogenesis of peptidylglycyl α-amidation activity in the mouse hypothalamus in vivo and in serum-free medium cultures. Relation with thyroliberin (TRH) accumulation and release in vitro, Brain Res., 468 (1988) 261-267.
5. Finley, J., Lindstrom, P. and Petrusz, P., Immunocytochemical localization of β-endorphin-containing neurons in the rat brain, Neuroendocrinology, 33 (1981) 28-42.
6. Glembotski, C.C., The role of ascorbic acid in the biosynthesis of the neuroendocrine peptides α-MSH and TRH, Annu. NY. Acad. Sci., 498 (1987) 54-62.
7. Hodges, R.E., Hood, J., Canaham, J.E., Sanberlich, H.E. and Baker, E.M., Clinical manifestations of ascorbic acid deficiency in man, Am. J. Clin. Nutr., 24 (1971) 432-443.
8. Hornig, D., Distribution of ascorbic acid, metabolites and analogues in man and animals, Annu. NY. Acad. Sci., 258 (1975) 103-118.
9. Huang, W., Yang, Z., Lee, D., Copolov, D.L. and Lim, A.T., Ascorbic acid enhances forskolin-induced cyclic AMP production and pro-ANP mRNA expression of hypothalamic neurons in culture, Endocrinology, 132 (1992) 2271-2273.
10. Kalir, H.H. and Mytilineou, C., Ascorbic acid in mesencephalic cultures: effects on dopaminergic neuron development, J. Neurochemistry, 57 (2) 458-464.
11. Krupinski, J., The adenylyl cyclase family, Mol. Cell Biochem., 104 (1991) 3-79.
12. Laatikainen, T.J., Corticotropin-releasing hormone and opioid peptides in reproduction and stress, Ann. Med, 23 (1991) 489-496.
13. Lewis, M.E., Sherman, T.G., Burke, S., Akil, H., Davis, L.G., Arentzen, R. and Watson, S.J., Detection of proopiomelanocortin mRNA by in situ hybridization with an oligonucleotide probe, Proc. Nail. Acad. Sci. USA., 83 (1986) 5419-5423.
14. Mains, R.E., Cullen, E.I., May, V. and Eipper, B.A., The role of secretory granules in peptide biosynthesis, Annu. NY. Acad. Sci., 493 (1987) 278-291.
15. Marley, P.D., Thomson, K.A., Jachno, K. and Johnston, M.J., Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells, Br. J. Pharmacol., 104 (1991) 839-846.
16. Milby, K., Oke, A. and Adams, R.N., Detailed mapping of ascorbate distribution in rat brain, Neurosci. Lett., 28 (1982) 15-20.
17. Miller, B.T. and Cicero, T.J., Ascorbic acid enhances the release of luteining hormone-releasing hormone from the mediobasal hypothalamus in vitro, Life Sci., 39 (1986) 2447-2454.
18. Morre, D.J., Crane, F.L., Sun, I.L. and Navas, P., The role of ascorbate in biomembrane energetics, Annu. NY. Acad. Sci., 498 (1987) 153-171.
19. Njus, D., Knoth, J., Cook, C. and Kelly, P.M., Electron transfer across the chromaffin granule membrane, J. Biol. Chem., 258 (1983) 27-30.
20. Ojeda, S.R., Urbanski, H.F. and Ahmed, C.E., The onset of female puberty: studies in the rat, Recent Prog. Horm. Res., 42 (1986) 385-442.
21. Padh, H., Cellular functions of ascorbic acid, Biochem. Cell Biol., 68 (1990) 1166-1173.
22. Seifer, D.B. and Collins, R.L., Current concepts of β-endorphin physiology in female reproductive dysfunction, Fertil. Steril., 54 (1990) 757-771.
23. Skotland, T. and Ljones, T., Direct spectrophotometric detection of ascorbate free radical formed by dopamine β-monooxygenase and by ascorbate oxidase, Biochim. Biophys. Acta, 630 (1980) 30-50.
24. Tang, W.J., Krupinski, J. and Gilman, A.G., Expression and characterization of calmodulin-activated (type I) adenylylcyclase, J. Biol. Chem., 266 (1991) 8595-8603.
25. Xia, Z.G., Refsdal, C.D., Merchant, K.M., Dorsa, D.M. and Storm, D.R., Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: expression in areas associated with learning and memory, Neuron, 6 (1991) 431-443.
26. Yang, Z., Huang, W., Lee, D., Copolov, D.L. and Lim, A.T., The adenylyl cyclase-cAMP system modulates morphological and functional development of hypothalamic β-endorphin neurons in culture, J. Neuroendocrinology, 5 (1993) 371-380.
27. Yang, Z., Lee, D., Huang, W., Copolov, D.L. and Lim, A.T., Glucocorticoids potentiate the adenylyl cyclase-cAMP system mediated ir-β-endorphin production and secretion from hypothalamic neurons in culture, Brain Res., 648 (1994) 99-108.
28. Yang, Z., Copolov, D.L. and Lim, A.T., Progesterone but not estrogen modulates the cAMP system mediated ir-β-endorphin secretion and POMC mRNA expression from rat hypothalamic cells in culture, Brain Res., 678 (1995) 251-258.