Complement activation products in the urine from proteinuric patients

Journal of the American Society of Nephrology

Volumn 11, Issue 4, 2000, Pages 700-707

  Morita, Yoshiki ^a   Ikeguchi, Hiroshi ^a   Nakamura, Jiro ^a   Hotta, Nigishi ^a   Yuzawa, Yukio ^a   Matsuo, Seiichi ^a,b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C9; CREATININE; PLASMA PROTEIN;

ADULT; AGED; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULOSCLEROSIS; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FAILURE; KIDNEY TUBULE DISORDER; MAJOR CLINICAL STUDY; MALE; METABOLIC ACIDOSIS; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROTEINURIA; URINALYSIS;

EID: 0034068043     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Schainuck LI, Striker GE, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. Part II. The correlations. Hum Pathol 1: 631-640, 1970
2. Bohle A, Wehrmann M, Bogenschutz O, Batz C, Vogl W, Schmitt H, Muller CA, Muller GA: The long-term prognosis of the primary glomerulonephritis: A morphological and clinical analysis of 1747 cases. Pathol Res Pract 188: 908-924, 1992
3. Peterson JC, Adler S, Burkart JM, Greene T, Hebert LA, Hunsicker L, King AJ, Klahr S, Massry SG, Seifter JL, for the MDRD Study Group: Blood pressure control, proteinuria and the progression of renal disease. Ann Intern Med 123: 754-762, 1995
4. Remuzzi G, Ruggenenti P, Benigni A: Understanding the nature of renal disease progression. Kidney Int 51: 2-15, 1997
5. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G, on behalf of the "Gruppo Italiano di Studi Epidemiologici in Nefrologia" (GISEN): Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. Kidney Int 53: 1209-1216, 1998
6. Thomas ME, Schreiner GF: Contribution of proteinuria to progressive renal injury: Consequences of tubular uptake of fatty acid bearing albumin. Am J Nephrol 13: 385-398, 1993
7. Kees-Folts D, Sadow JL, Schreiner GF: Tubular catabolism of albumin is associated with the release of an inflammatory lipid. Kidney Int 45: 1697-1709, 1994
8. Zoja C, Donadelli R, Colleoni S, Figliuzzi M, Bonazzola S, Morigi M, Remuzzi G: Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation. Kidney Int 53: 1608-1615, 1998
9. Alfrey AC, Froment DH, Hammond WS: Role of iron in the tubulo-interstitial injury in nephrotoxic serum nephritis. Kidney Int 36: 753-759, 1989
10. Chen L, Wang Y, Tay YC, Harris DCH: Proteinuria and tubulointerstitial injury. Kidney Int 52: S60-S62, 1997
11. Ong ACM, Jowett TP, Moorhead JF, Owen JS: Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells. Kidney Int 46: 1315-1321, 1994
12. Nath KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20: 1-17, 1992
13. Eddy AA: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5: 1273-1287, 1994
14. Benigni A, Zoya C, Remuzzi G: The renal toxicity of sustained glomerular protein traffic. Lab Invest 73: 461-468, 1995
15. Burton C, Harris KPG: The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 27: 765-775, 1996
16. Bruzzi I, Benigni A, Remuzzi G: Role of increased glomerular protein traffic in the progression of renal failure. Kidney Int 52[Suppl 62]: S29-S31, 1997
17. Sato K, Ullrich KJ: Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. II. Evidence that complement is involved. Biochem Biophys Acta 354: 182-187, 1974
18. Camussi G, Rotunno M, Segoloni G, Brentjens JR, Andres GA: In vitro alternative pathway activation of complement by the brush border of proximal tubules of normal rat kidney. J Immunol 128: 1659-1663, 1982
19. Biancone L, David S, Pietra DV, Montrucchio G, Cambi V, Camussi G: Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney Int 45: 451-460, 1994
20. Williams DJ, Coles AG: Proteinuria: A direct cause of renal morbidity? Kidney Int 45: 443-450, 1994
21. Khan TN, Sinniah R: Role of complement in renal tubular damage. Histopathology 26: 351-356, 1995
22. David S, Biancone L, Caserta C, Bussolati B, Cambi V, Camussi G: Alternative pathway complement activation induces proinflammatory activity in human proximal tubular epithelial cells. Nephrol Dial Transplant 12: 51-56, 1997
23. Abbate M, Zoya C, Rottoli D, Corna D, Perico N, Bertani T, Remuzzi G: Antiproteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein-and complement-dependent interstitial inflammation in experimental renal disease. J Am Soc Nephrol 10: 804-813, 1999
24. Camussi G, Stratta P, Mazzucco G, Gaido M, Tetta C, Castello R, Rotunno M, Vercellone A: In vivo localization of C3 on the brush border of proximal tubules of kidneys from nephrotic patients. Clin Nephrol 23: 134-141, 1985
25. Schulze M, Baker PJ, Perkinson DT, Johnson RJ, Ochi RF, Stahl RAK, Couser WG: Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat. Kidney Int 35: 60-68, 1989
26. Schulze M, Donadio JV, Pruchno CJ, Baker PJ, Johnson RJ, Stahl RAK, Watkins S, Martin DC, Wurzner R, Gotze O, Couser WG: Elevated urinary excretion of the C5b-9 complex in membranous nephropathy. Kidney Int 40: 533-538, 1991
27. Kerjaschki D, Schulze M, Binder S, Kain R, Ojha PP, Susani M, Horvat R, Baker PJ, Couser WG: Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143: 546-552, 1989
28. Ogrodowski JL, Hebert LA, Sedmak D, Cosio FG, Tamerius J, Kolb W: Measurement of SC5b-9 in urine patients with the nephrotic syndrome. Kidney Int 40: 1141-1147, 1991
29. Morita Y, Nomura A, Yuzawa Y, Nishikawa K, Hotta N, Shimizu F, Matsuo S: The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis. J Am Soc Nephrol 8: 1363-1372, 1997
30. Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S: Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis. Am J Pathol 151: 539-547, 1997
31. Ichida S, Yuzawa Y, Okada H, Yoshioka K, Matsuo S: Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 46: 89-96, 1994
32. Tack BF, Harrison RA, Janatova J, Thomas ML, Prahl JW: Evidence for presence of an internal thiolester bond in the third component of human complement. Proc Natl Acad Sci USA 77: 5764-5788, 1980
33. Howard JB: Methylamine reaction and denaturation-dependent fragmentation of complement component 3. J Biol Chem 255: 7082-7084, 1980
34. Schoolwerth AC, Sandler RS, Hoffman PM, Klahr S: Effects of nephron reduction and dietary protein content on renal ammoniagenesis in the rat. Kidney Int 7: 397-404, 1975
35. Nath KA, Hostetter MK, Hostetter TH: Pathophysiology of chronic tubulo-interstitial disease in rats: Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 76: 667-675, 1985
36. Tolins JP, Hostetter MK, Hostetter TH: Hypokalemic nephropathy in the rat: Role of ammonia in chronic tubular injury. J Clin Invest 79: 1447-1458, 1987
37. Rustom R, Jackson MJ, Critchley M, Bone JM: Tubular metabolism of aprotinin 99mTc and urinary ammonia: Effects of proteinuria. Miner Electrolyte Metab 18: 108-112, 1992
38. Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y: Proteinuria and damage to tubular cells: Is complement a culprit? Nephrol Dial Transplant 13: 2723-2726, 1998
39. Rustom R, Maltby P, Grime JS, Hughes A, Costigan M, Shenkin A, Critchley M, Bone JM: Tubular peptide hypermetabolism and urinary ammonia in chronic renal failure in man: A maladaptive response? Nephron 79: 306-311, 1998
40. Weisman HF, Bartow T, Leppo MK, Marsh JHC, Carson GR, Concino MF, Boyle MP, Roux KH, Weisfeldt ML, Fearon DT: Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249: 146-151, 1990
41. Nadasdy T, Silva FG, Hogg RJ: Minimal change nephrotic syndrome-focal sclerosis complex (including IgM nephropathy and diffuse mesangial hypercellularity). In: Renal Pathology with Clinical and Functional Correlations, edited by Tisher CC, Brenner BM, Philadelphia, Lippincott, 1994, pp 330-389
42. Volanakis JE, Barnum SR, Guddens M, Galla JH: Renal filtration and catabolism of complement protein D. N Engl J Med 312: 395-399, 1985
43. Rustom R, Grime JS, Costigan M, Maltby P, Hughes A, Taylor W, Shenkin A, Critchley M, Bone JM: Oral sodium bicarbonate reduces proximal renal tubular peptide catabolism, ammoniogenesis, and tubular damage in renal patients. Ren Failure 20: 371-382, 1998