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The medical services costs associated with infusion of medications are typically a small percentage of the acquisition costs for biologics. For example, Wu and colleagues found that the annual drug administration cost for infliximab, a biologic medication infused in the outpatient setting for the treatment of rheumatoid arthritis, was $725 and represented 4 percent of the annual cost of the drug. E. Wu et al, Cost of Care for Patients with Rheumatoid Arthritis Receiving TNF-Antagonist Therapy Using Claims Data, Current Medical Research and Opinion 23, no. 8 2007, 1749-1759
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In addition, changes in payment methodologies to physicians for drugs administered in their offices have greatly decreased reimbursement for the drug product. This may affect patient care if physicians decide not to administer drugs in their offices and refer patients to outpatient infusion centers for treatment; research on the influence of these reimbursement changes on the quality of care is needed. D. Stern and D. Reissman, Specialty Pharmacy Cost Management Strategies of Private Health Care Payers, Journal of Managed Care Pharmacy 12, no. 9 2006, 736-744
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