Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma

Cancer Science

Volumn 99, Issue 7, 2008, Pages 1390-1400

  Nakamura, Erina ^a   Kozaki, Ken Ichi ^a,b   Tsuda, Hitoshi ^a,b,c   Suzuki, Emina ^a   Pimkhaokham, Atiphan ^a,d   Yamamoto, Gou ^e   Irie, Tarou ^e   Tachikawa, Tetsuhiko ^e   Amagasa, Teruo ^a   Inazawa, Johji ^a,b   Imoto, Issei ^a,b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^d CHULALONGKORN UNIVERSITY   (Thailand)

^e SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MELATONIN; MELATONIN RECEPTOR; MELATONIN RECEPTOR 1A; MESSENGER RNA;

ADULT; AGED; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CELL IMMORTALIZATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CORRELATION FUNCTION; CPG ISLAND; EPIGENETICS; EPITHELIUM CELL; FEMALE; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GENE SILENCING; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUTH CARCINOMA; MULTIVARIATE ANALYSIS; ORAL SURGERY; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 4; CPG ISLANDS; DNA METHYLATION; GENE DELETION; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MOUTH NEOPLASMS; PROMOTER REGIONS (GENETICS); RECEPTOR, MELATONIN, MT1;

EID: 44449131529     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00838.x     Document Type: Article

References (38)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Nomura K, Sobue T, Nakatani H et al. Number of deaths and proportional mortality rates from malignant neoplasms by site in Japan (2003). In: Editorial Board of Cancer Statistics in Japan, eds. Cancer Statistics in Japan 2005. Tokyo: National Cancer Center, 2005; 36-9.
3. Lippman SM, Hong WK. Molecular markers of the risk of oral cancer. N Engl J Med 2001; 344: 1323-6.
4. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN): 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol 2000; 36: 256-63.
5. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-28.
6. Ha PK, Califano JA. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol 2006; 7: 77-82.
7. Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I. Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma. Cancer Sci 2006; 97: 1070-4.
8. Snijders AM, Schmidt BL, Fridlyand J et al. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene 2005; 24: 4232-42.
9. Baldwin C, Garnis C, Zhang L, Rosin MP, Lam WL. Multiple microalterations detected at high frequency in oral cancer. Cancer Res 2005; 65: 7561-7.
10. Liu CJ, Lin SC, Chen YJ, Chang KM, Chang KW. Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Mol Carcinog 2006; 45: 721-31.
11. Nakaya K, Yamagata HD, Arita N et al. Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene 2007; 26: 5300-8.
12. Inazawa J, Inoue J, Imoto I. Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes. Cancer Sci 2004; 95: 559-63.
13. Suzuki E, Imoto I, Pimkhaokham A et al. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene 2007; 26: 7921-32.
14. Tamarkin L, Cohen M, Roselle D, Reichert C, Lippman M, Chabner B. Melatonin inhibition and pinealectomy enhancement of 7,12 dimethylbenz (a) anthracene-induced mammary tumors in the rat. Cancer Res 1981; 41: 4432-6.
15. Blask DE, Sauer LA, Dauchy LA, Holowachuk EW, Ruhoff MS. New insights into melatonin regulation of cancer growth. Adv Exp Med Biol 1999; 460: 337-43.
16. Yuan L, Collins AR, Dai J, Dubocovich ML, Hill SM. Overexpression of the mt1 melatonin receptor enhances melatonin's growth-suppression of human breast cancer cells. Mol Cell Endocrinol 2002; 192: 147-56.
17. Collins A, Yuan L, Kiefer TL, Cheng Q, Lai L, Hill SM. Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells inhibits mammary tumor formation in nude mice. Cancer Lett 2003; 189: 49-57.
18. Bartsch C, Bartsch H. The anti-tumor activity of pineal melatonin and cancer enhancing life styles in industrialized societies. Cancer Causes Control 2006; 17: 559-71.
19. Vijayalaxmi Thomas CR Jr, Reiter RJ, Herman TS. Melatonin: From basic research to cancer treatment clinics. J Clin Oncol 2002; 20: 2575-601.
20. Jung B, Ahmad N. Melatonin in cancer management: Progress and promise. Cancer Res 2006; 66: 9789-93.
21. Akanuma D, Uzawa N, Yoshida MA, Negishi A, Amagasa T, Ikeuchi T. Inactivation patterns of the p16 (INK4a) gene in oral squamous cell carcinoma cell lines. Oral Oncol 1999; 35: 476-83.
22. Fujimoto R, Kamata N, Yokoyama K et al. Establishment of immortalized human oral keratinocytes by gene transfer of a telomerase component. J Jpn Oral Muco Membr (Jpn) 2002; 8: 1-8.
23. Xiong Z, Laird PW. COBRA: A sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997; 25: 2532-4.
24. Imoto I, Tsuda H, Hirasawa A et al. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res 2002; 62: 4860-6.
25. Hermsen MA, Joenje H, Arwert F et al. Assessment of chromosomal gains and losses in oral squamous cell carcinoma by comparative genomic hybridisation. Oral Oncol 1997; 33: 414-18.
26. Wolff E, Girod S, Liehr T et al. Oral squamous cell carcinomas are characterized by a rather uniform pattern of genomic imbalances detected by comparative genomic hybridisation. Oral Oncol 1998; 34: 186-90.
27. Chen YJ, Lin SC, Kao T et al. Genome profiling of oral squamous cell carcinoma. J Pathol 2004; 204: 326-32.
28. Brzezinski A. Melatonin in humans. New Eng J Med 1997; 336: 186-95.
29. Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI. Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 2003; 8: D1093-108.
30. Martin V, Herrera F, Carrera-Gonzalez P et al. Intracellular signaling pathways involved in the cell growth inhibition of glioma cells by melatonin. Cancer Res 2006; 66: 1081-8.
31. Cutando A, Gómez-Moreno G, Arana C, Acuña-Castroviejo D, Reiter RJ. Melatonin: Potential functions in the oral cavity. J Periodontol 2007; 78: 1094-102.
32. Ram PT, Dai J, Yuan L et al. Involvement of the mt1 melatonin receptor in human breast cancer. Cancer Lett 2002; 179: 141-50.
33. Jones MP, Melan MA, Witt-Enderby PA. Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner. Cancer Lett 2000; 151: 133-43.
34. Czesnikiewicz-Guzik M, Konturek SJ, Loster B, Wisniewska G, Majewski S. Melatonin and its role in oxidative stress related diseases of oral cavity. J Physiol Pharmacol 2007; 58 (Suppl 3): 5-19.
35. Kolb A. The first intron of the murine â-casein gene contains a functional promoter. Biochem Biophys Res Commun 2003; 306: 1099-105.
36. Nakagawachi T, Soejima H, Urano T et al. Silencing effect of CpG island hypermethylation and histone modifications on O 6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene 2003; 22: 8835-44.
37. Sonoda I, Imoto I, Inoue J et al. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res 2004; 64: 3741-7.
38. Misawa A, Inoue J, Sugino Y et al. Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplicon. Cancer Res 2005; 65: 10233-42.