The effect of 2-methoxyestradiol, a HIF-1α inhibitor, in global cerebral ischemia in rats

Neurological Research

Volumn 30, Issue 3, 2008, Pages 268-271

  Zhou, Dachun ^a   Matchett, Gerald A ^b   Jadhav, Vikram ^a   Dach, Neal ^a   Zhang, John H ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

2 methoxyestradiol; Global ischemia; Hypoxia inducible factor

Indexed keywords

2 METHOXYESTRADIOL; DIMETHYL SULFOXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CELL COUNT; CELL SURVIVAL; CONTROLLED STUDY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; REPERFUSION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ESTRADIOL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 44449129416     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164107X229920     Document Type: Article

References (10)

1. Allen JS, Tranel D, Bruss J, et al. Correlations between regional brain volumes and memory performance in anoxia. J Clin Exp Neuropsychol 2006; 28: 457-476
2. Sugawara T, Lewen A, Noshita N, et al. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 2002; 19: 85-89
3. Popp E, Bottiger B. Cerebral resuscitation: State of the art, experimental approaches, and clinical perspectives. Neurol Clin 2006; 24: 73-87
4. Helton R, Cui J, Scheel JR, et al. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci 2005; 25: 4099-4107
5. Ricker JL, Chen Z, Yang XP, et al. 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res 2004; 10: 8665-8673
6. Smith ML, Bendek G, Dahlgren N, et al. Models for studying longterm recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model. Acta Neurol Scand 1984; 69: 385-401
7. Matchett G, Hahn J, Obenaus A, et al. Surgically induced brain injury in rats: The effect of erythropoietin. J Neurosci Methods 2006; 158: 234-241
8. Shimamura N, Matchett G, Yatsushige, et al. Inhibition of integrin alphavbeta3 ameliorates focal cerebral ischemic damage in the rat middle cerebral artery occlusion model. Stroke 2006; 37: 1902-1909
9. Picazo O, Azcoitia I, Garcia-Segura LM. Neuroprotective and neurotoxic effects of estrogens. Brain Res 2004; 990: 20-27
10. Nakagawa-Yagi Y, Nobou O, Yutaka I, et al. The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal death in vitro. Life Sci 1996; 58: 1461-1467