Aristolochic acid: The common culprit of Chinese herbs nephropathy and Balkan endemic nephropathy

Nephrology Dialysis Transplantation

Volumn 23, Issue 1, 2008, Pages 39-41

  De Jonge, Hylke ^a   Vanrenterghem, Yves ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Aristolochic acid; Balkan endemic nephropathy; Chinese herbs nephropathy; Urothelial malignancies

Indexed keywords

ARISTOLOCHIC ACID; HERBACEOUS AGENT;

ARTICLE; BALKAN ENDEMIC NEPHROPATHY; CASE REPORT; CHINESE HERB; CHINESE HERB NEPHROPATHY; DIETARY INTAKE; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; HEREDITY; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; PRIORITY JOURNAL; UROGENITAL TRACT CANCER; WHEAT; CHEMICALLY INDUCED DISORDER; REVIEW;

ARISTOLOCHIC ACIDS; BALKAN NEPHROPATHY; DRUGS, CHINESE HERBAL; HUMANS; KIDNEY DISEASES;

EID: 44449122314     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm667     Document Type: Article

References (16)

1. Stefanovic V, Polenakovic MH. Balkan nephropathy. Kidney disease beyond the Balkans? Am J Nephrol 1991; 11: 1-11
2. Stefanovic V, Toncheva D, Atanasova S, Polenakovic MH. Etiology of Balkan endemic nephropathy and associated urothelial cancer. Am J Nephrol 2006; 26: 1-11
3. Ivic M. The problem of etiology of endemic nephropathy. Acta Fac Med Naiss 1970; 1: 29-37
4. Long DT, Voice TC. Role of exposure analysis in solving the mystery of Balkan endemic nephropathy. Croat Med J 2007; 48: 300-311
5. Hranjec T, Kovac A, Kos J et al. Endemic nephropathy: the case for chronic poisoning by aristolochia. Croat Med J 2005; 46: 116-125
6. Vanherweghem J-L, Depierreux M, Tielemans C et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-391
7. Cosyns JP. Aristolochic acid and "Chinese herbs nephropathy": a review of the evidence to date. Drug Saf 2003; 26: 33-48
8. Schmeiser HH, Bieler CA, Wiessler M et al. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996; 56: 2025-2028
9. Arlt VM, Pfohl-Leszkowicz A, Cosyns JP et al. Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. Mutat Res/Genet Toxicol Environ Mutagen 2001; 494: 143-150
10. Nortier JL, Martinez MCM, Schmeiser HH et al. Urothelial Carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 2000; 342: 1686-1692
11. Bieler CA, Stiborova M, Wiessler M et al. 32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 1997; 18: 1063-1067
12. Cosyns J-P, Jadoul M, Squifflet J-P et al. Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 1994; 45: 1680-1688
13. Arlt VM, Ferluga D, Stiborova M et al. Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer? Int J Cancer 2002; 101: 500-502
14. Grollman AP, Shibutani S, Moriya M et al. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. PNAS 2007; 104: 12129-12134
15. Arlt VM, Stiborova M, Brocke JV et al. Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer. Carcinogenesis Advance Access 2007; doi:10.1093/carcin/bgm082
16. Kessler DA. Cancer and Herbs. N Engl J Med 2000; 342: 1742-1743