The impact of smoking on thyroid volume and function in relation to a shift towards iodine sufficiency

European Journal of Epidemiology

Volumn 23, Issue 6, 2008, Pages 423-429

  Vejbjerg, Pernille ^a,b   Knudsen, Nils ^a,b   Perrild, Hans ^a   Carlé, Allan ^c   Laurberg, Peter ^c   Pedersen, Inge Bülow ^c   Rasmussen, Lone B ^d   Ovesen, Lars ^e   Jørgensen, Torben ^b  

^a BISPEBJERG HOSPITAL   (Denmark)

^b Research Centre for Prevention and Health   (Denmark)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e The Danish National Foundation Research Center for Heart Arrhythmia   (Denmark)

Author keywords

Iodine status; Smoking; Thyroid enlargement; Thyroid volume

Indexed keywords

IODINE; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CIGARETTE SMOKING; CONFIDENCE INTERVAL; ECHOGRAPHY; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GOITER; HUMAN; IODINATION; IODINE DEFICIENCY; LIFESTYLE; LIOTHYRONINE BLOOD LEVEL; MALE; QUESTIONNAIRE; THYROID FUNCTION; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; CROSS-SECTIONAL STUDIES; DENMARK; HUMANS; HYPERTHYROIDISM; IODINE; LOGISTIC MODELS; MALE; MIDDLE AGED; QUESTIONNAIRES; SMOKING; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN;

EID: 44449108985     PISSN: 03932990     EISSN: 15737284     Source Type: Journal    
DOI: 10.1007/s10654-008-9255-1     Document Type: Article

References (34)

1. Meikle AW, Stringham JD, Woodward MG, Nelson JC. Hereditary and environmental influences on the variation of thyroid hormones in normal male twins. J Clin Endocrinol Metab. 1988;66:588-92.
2. Knudsen N, Laurberg P, Perrild H, Bulow I, Ovesen L, Jorgensen T. Risk factors for goiter and thyroid nodules. Thyroid. 2002;12:879-88.
3. Hansen PS, Brix TH, Bennedbaek FN, Bonnema SJ, Kyvik KO, Hegedus L. Genetic and environmental causes of individual differences in thyroid size: a study of healthy Danish twins. J Clin Endocrinol Metab. 2004;89:2071-7.
4. Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H. Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status. Clin Endocrinol (Oxf). 2000;53:479-85.
5. Knudsen N, Bulow I, Laurberg P, Ovesen L, Perrild H, Jorgensen T. Association of tobacco smoking with goiter in a low-iodine-intake area. Arch Intern Med. 2002;162:439-43.
6. Hegedus L, Karstrup S, Veiergang D, Jacobsen B, Skovsted L, Feldt-Rasmussen U. High frequency of goitre in cigarette smokers. Clin Endocrinol (Oxf). 1985;22:287-92.
7. Georgiadis E, Papapostolou C, Korakis T, Evagelopoulou K, Mantzoros C, Batrinos M. The influence of smoking habits on thyroid gland volume: an ultrasonic approach. J R Soc Health. 1997;117:355-8.
8. Barrere X, Valeix P, Preziosi P, Bensimon M, Pelletier B, Galan P, et al. Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clin Endocrinol (Oxf). 2000;52:273-8.
9. Volzke H, Schwahn C, Kohlmann T, Kramer A, Robinson DM, John U, et al. Risk factors for goiter in a previously iodine-deficient region. Exp Clin Endocrinol Diabetes. 2005;113:507-15.
10. Berghout A, Wiersinga WM, Smits NJ, Touber JL. Determinants of thyroid volume as measured by ultrasonography in healthy adults in a non-iodine deficient area. Clin Endocrinol (Oxf). 1987;26:273-80.
11. Petersen K, Lindstedt G, Lundberg PA, Bengtsson C, Lapidus L, Nystrom E. Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking. J Intern Med. 1991;229:407-13.
12. Prummel MF, Wiersinga WM. Smoking and risk of Graves' disease. JAMA. 1993;269:479-82.
13. Gomez JM, Maravall FJ, Gomez N, Guma A, Soler J. Determinants of thyroid volume as measured by ultrasonography in healthy adults randomly selected. Clin Endocrinol (Oxf). 2000;53:629-34.
14. Christensen SB, Ericsson UB, Janzon L, Tibblin S, Melander A. Influence of cigarette smoking on goiter formation, thyroglobulin, and thyroid hormone levels in women. J Clin Endocrinol Metab. 1984;58:615-8.
15. Olbricht T, Hoff HG. Factors affecting thyroid gland volume. A contribution to the epidemiology of struma. Med Klin (Munich). 1988;83:279-84.
16. Bartalena L, Martino E, Marcocci C, Bogazzi F, Panicucci M, Velluzzi F, et al. More on smoking habits and Graves' ophthalmopathy. J Endocrinol Invest. 1989;12:733-7.
17. Galanti MR, Granath F, Cnattingius S, Ekbom-Schnell A, Ekbom A. Cigarette smoking and the risk of goitre and thyroid nodules amongst parous women. J Intern Med. 2005;258:257-64.
18. Ericsson UB, Lindgarde F. Effects of cigarette smoking on thyroid function and the prevalence of goitre, thyrotoxicosis and autoimmune thyroiditis. J Intern Med. 1991;229:67-71.
19. Jorde R, Sundsfjord J. Serum TSH levels in smokers and non-smokers. The 5th Tromso study. Exp Clin Endocrinol Diabetes. 2006;114:343-7.
20. Knudsen N, Bulow I, Laurberg P, Perrild H, Ovesen L, Jorgensen T. High occurrence of thyroid multinodularity and low occurrence of subclinical hypothyroidism among tobacco smokers in a large population study. J Endocrinol. 2002;175:571-6.
21. Belin RM, Astor BC, Powe NR, Ladenson PW. Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2004;89:6077-86.
22. Rasmussen LB, Ovesen L, Bulow I, Jorgensen T, Knudsen N, Laurberg P, et al. Dietary iodine intake and urinary iodine excretion in a Danish population: effect of geography, supplements and food choice. Br J Nutr. 2002;87:61-9.
23. Vejbjerg P, Knudsen N, Perrild H, Carle A, Laurberg P, Pedersen IB, et al. Effect of a mandatory iodization program on thyroid gland volume based on individuals' age, gender, and preceding severity of dietary iodine deficiency: a prospective, population-based study. J Clin Endocrinol Metab. 2007;92:1397-401.
24. Laurberg P, Jorgensen T, Perrild H, Ovesen L, Knudsen N, Pedersen IB, et al. The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives. Eur J Endocrinol. 2006;155:219-28.
25. Gutekunst R, Becker W, Hehrmann R, Olbricht T, Pfannenstiel P. Ultrasonic diagnosis of the thyroid gland. Dtsch Med Wochenschr. 1988;113:1109-12.
26. Knudsen N, Bols B, Bulow I, Jorgensen T, Perrild H, Ovesen L, et al. Validation of ultrasonography of the thyroid gland for epidemiological purposes. Thyroid. 1999;9:1069-74.
27. WHO, UNICEFF and ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination. A guide for programme managers. Geneva: WHO; 2001.
28. Gehan EA, George SL. Estimation of human body surface area from height and weight. Cancer Chemother Rep. 1970;54:225-35.
29. Greenland S, Rothman KJ. Measures of effect and association. In: Rothman KJ, Greenland S, editors. Modern epidemiology. Philadelphia: Lippincott-Raven Publishers; 1998. p. 47-64.
30. Lio S, Napolitano G, Marinuzzi G, Monaco F. Role of smoking in goiter morphology and thyrotropin response to TRH in untreated goitrous women. J Endocrinol Invest. 1989;12:93-7.
31. Fukayama H, Nasu M, Murakami S, Sugawara M. Examination of antithyroid effects of smoking products in cultured thyroid follicles: only thiocyanate is a potent antithyroid agent. Acta Endocrinol (Copenh). 1992;127:520-5.
32. Brauer VF, Below H, Kramer A, Fuhrer D, Paschke R. The role of thiocyanate in the etiology of goiter in an industrial metropolitan area. Eur J Endocrinol. 2006;154:229-35.
33. Cryer PE, Haymond MW, Santiago JV, Shah SD. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med. 1976;295:573-7.
34. Colzani R, Fang SL, Alex S, Braverman LE. The effect of nicotine on thyroid function in rats. Metabolism. 1998;47:154-7.