Tracking and trapping somatic mutations in Ig genes

Journal of Immunology

Volumn 180, Issue 9, 2008, Pages 5763-5764

  Radic, Marko ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(4 HYDROXY 3 NITRO PHENYL)ACETYL PHOSPHORYLCHOLINE; 2 PHENYL OXAZOLONE; 4 AZOPHENYLARSONATE; BENZENE DERIVATIVE; CHOLINE; IMMUNOGLOBULIN M ANTIBODY; MESSENGER RNA; OXAZOLONE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN KAPPA CHAIN; MONOCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS HEMAGGLUTININ;

AMINO ACID SEQUENCE; B LYMPHOCYTE; BACTERIAL GENE; GENE EXPRESSION; GENETIC RECOMBINATION; GENETIC VARIABILITY; HUMORAL IMMUNITY; HYBRIDOMA; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN BINDING; SHORT SURVEY; SOMATIC MUTATION; STOP CODON; ANIMAL; BAGG ALBINO MOUSE; COMPLEMENTARITY DETERMINING REGION; CYTOLOGY; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; INFLUENZA VIRUS A H1N1; MOUSE; NOTE; QUANTITATIVE TRAIT LOCUS; SOMATIC HYPERMUTATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; COMPLEMENTARITY DETERMINING REGIONS; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; HEMAGGLUTININS, VIRAL; HYBRIDOMAS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE; MICE, INBRED BALB C; QUANTITATIVE TRAIT LOCI; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 44449092112     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.9.5763     Document Type: Short Survey

References (22)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302: 575-581.
2. Weigert, M. G., I. M. Cesari, S. J. Yonkovich, and M. Cohn. 1970. Variability in the λ light chain sequences of mouse antibody. Nature 228: 1045-1047.
3. Weigert, M. G., and A. Garen. 1965. Base composition of nonsense codons in E. coli. Evidence from amino-acid substitutions at a tryptophan site in alkaline phosphatase. Nature 206: 992-994.
4. Wu, T. T., and E. A. Kabat. 1970. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp. Med. 132: 211-250.
5. Tonegawa, S. 1976. Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity. Proc. Natl. Acad. Sci. USA 73: 203-207.
6. Weigert, M., L. Gatmaitan, E. Loh, J. Schilling, and L. Hood. 1978. Rearrangement of genetic information may produce immunoglobulin diversity. Nature 276: 785-790. (Pubitemid 9061979)
7. Valbuena, O., K. B. Marcu, M. Weigert, and R. P. Perry. 1978. Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity. Nature 276: 780-784. (Pubitemid 9061978)
8. Bothwell, A. L., M. Paskind, M. Reth, T. Imanishi-Kari, K. Rajewsky, and D. Baltimore. 1981. Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ 2a variable region. Cell 24: 625-637. (Pubitemid 11071302)
9. Lieberman, R., M. Potter, E. B. Mushinski, W. Humphrey, Jr., and S. Rudikoff. 1974. Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine. J. Exp. Med. 139: 983-1001.
10. Siekevitz, M., M. L. Gefter, P. Brodeur, R. Riblet, and A. Marshak-Rothstein. 1982. The genetic basis of antibody production: the dominant anti-arsonate idiotype response of the strain A mouse. Eur. J. Immunol. 12: 1023-1032. (Pubitemid 13168047)
11. Griffiths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312: 271-275. (Pubitemid 15202003)
12. Gearhart, P. J., N. D. Johnson, R. Douglas, and L. Hood. 1981. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature 291: 29-34. (Pubitemid 11125250)
13. Rudikoff, S., A. M. Giusti, W. D. Cook, and M. D. Scharff. 1982. Single amino acid substitution altering antigen-binding specificity. Proc. Natl. Acad. Sci. USA 79: 1979-1983. (Pubitemid 12088552)
14. McKean, D., K. Huppi, M. Bell, L. Staudt, W. Gerhard, and M. Weigert. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81: 3180-3184. (Pubitemid 14110702)
15. Wabl, M., P. D. Burrows, A. von Gabain, and C. Steinberg. 1985. Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. Proc. Natl. Acad. Sci. USA 82: 479-482. (Pubitemid 15128290)
16. Staudt, L. M., and W. Gerhard. 1983. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice. J. Exp. Med. 157: 687-704. (Pubitemid 13145069)
17. Clarke, S. H., K. Huppi, D. Ruezinsky, L. Staudt, W. Gerhard, and M. Weigert. 1985. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J. Exp. Med. 161: 687-704. (Pubitemid 15083770)
18. Berek, C., G. M. Griffiths, and C. Milstein. 1985. Molecular events during maturation of the immune response to oxazolone. Nature 316: 412-418. (Pubitemid 16238451)
19. Shlomchik, M. J., A. Marshak-Rothstein, C. B. Wolfowicz, T. L. Rothstein, and M. G. Weigert. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805-811. (Pubitemid 17118532)
20. Shlomchik, M., M. Mascelli, H. Shan, M. Z. Radic, D. Pisetsky, A. Marshak-Rothstein, and M. Weigert. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171: 265-292. (Pubitemid 20040614)
21. Nemazee, D., and M. Weigert. 2000. Revising B cell receptors. J. Exp. Med. 191: 1813-1817. (Pubitemid 30390345)
22. Muramatsu, M., H. Nagaoka, R. Shinkura, N. A. Begum, and T. Honjo. 2007. Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Adv. Immunol. 94: 1-36. (Pubitemid 46863447)