A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation

Oncogene

Volumn 27, Issue 24, 2008, Pages 3414-3423

  Pan, Q ^a,c   Zhu, Y J ^b   Gu, B W ^a   Cai, X ^a   Bai, X T ^a   Yun, H Y ^a   Zhu, J ^a   Chen, B ^a   Weng, L ^a   Chen, Z ^a   Xue, Y Q ^b   Chen, S J ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SOOCHOW UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Acute T lymphoid myeloid leukemia; Fusion gene; NUP98 IQCG

Indexed keywords

CYTARABINE; HOMODIMER; HYBRID PROTEIN; NUCLEOPORIN 98;

ACUTE DISEASE; AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; COILED BODY; CONTROLLED STUDY; DRUG INHIBITION; FUSION GENE; GENE REPRESSION; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; T CELL LEUKEMIA;

ADULT; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 3; COS CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, ACUTE; LEUKEMIA-LYMPHOMA, ADULT T-CELL; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; PHYLOGENY; RAS GTPASE-ACTIVATING PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSLOCATION, GENETIC;

ARA;

EID: 44449088416     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210999     Document Type: Article

References (25)

1. Bai XT, Gu BW, Yin T, Niu C, Xi XD, Zhang J et al. (2006). Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats. Cancer Res 66: 4584-4590.
2. Chung KY, Morrone G, Schuringa JJ, Plasilova M, Shieh JH, Zhang Y et al. (2006). Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Cancer Res 66: 11781-11791.
3. Gervais C, Mauvieux L, Perrusson N, Helias C, Struski S, Leymarie V et al. (2005). A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Leukemia 19: 145-148.
4. Gu BW, Wang Q, Wang JM, Xue YQ, Fang J, Wong KF et al. (2003). Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity. Leukemia 17: 1858-1864.
5. Gurevich RM, Aplan PD, Humphries RK. (2004). NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood 104: 1127-1136.
6. Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M et al. (2005). Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse mode. Blood 105: 784-793.
7. Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM. (1999). CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol 19: 764-776.
8. Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. (2001). NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 20: 350-361.
9. Lavau C, Szilvassy SJ, Slany R, Cleary ML. (1997). Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J 16: 4226-4237.
10. Lin YW, Slape C, Zhang Z, Aplan PD. (2005). NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood 106: 287-295.
11. Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S et al. (2000). Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Mol Cell 5: 811-820.
12. Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P et al. (2007). NUP98 dysregulation in myeloid leukemogenesis. Ann N Y Acad Sci 1106: 114-142.
13. Nakamura T. (2005). NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins. Int J Hematol 82: 21-27.
14. Nebral K, Schmidt HH, Haas OA, Strehl S. (2005). NUP98 is fused to topoisomerase (DNA) IIbeta 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15). Clin Cancer Res 11: 6489-6494.
15. Ohta H, Sekulovic S, Bakovic S, Eaves CJ, Pineault N, Gasparetto M et al. (2007). Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Exp Hematol 35: 817-830.
16. Panagopoulos I, Kerndrup G, Carlsen N, Strombeck B, Isaksson M, Johansson B. (2007). Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12). Br J Haematol 136: 294-296.
17. Radu A, Moore MS, Blobel G. (1995). The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell 81: 215-222.
18. Reader JC, Meekins JS, Gojo I, Ning Y. (2007). A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17) (p15;p13) in acute myeloid leukemia. Leukemia 21: 842-844.
19. Shaffer LG, Tommerup N. (2005). An International System for Human Cytogenetic Nomenclature (Cytogenetic & Genome Research). S Karger Pub: Basel, Switzerland.
20. Slape C, Aplan PD. (2004). The role of NUP98 gene fusions in hematologic malignancy. Leuk Lymphoma 45: 1341-1350.
21. Takeda A, Goolsby C, Yaseen NR. (2006). NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells. Cancer Res 66: 6628-6637.
22. Tosi S, Ballabio E, Teigler-Schlegel A, Boultwood J, Bruch J, Harbott J. (2005). Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. Genes Chromosomes Cancer 44: 225-232.
23. van Zutven LJ, Onen E, Velthuizen SC, van Drunen E, von Bergh AR, van den Heuvel-Eibrink MM et al. (2006). Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. Genes Chromosomes Cancer 45: 437-446.
24. Wang GG, Cai L, Pasillas MP, Kamps MP. (2007). NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 9: 804-812.
25. Xu L, Zhao WL, Xiong SM, Su XY, Zhao M, Wang C et al. (2001). Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia. Leukemia 15: 1359-1368.