Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 24, Issue 9, 2004, Pages 1696-1702

  Dichek, Helén L ^a   Qian, Kun ^a   Agrawal, Nalini ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Bridging function; Fatty liver; Hepatic lipase; Mouse models

Indexed keywords

ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN; ASPARTATE AMINOTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN; LIVER ENZYME; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FAST PROTEIN LIQUID CHROMATOGRAPHY; FATTY LIVER; FEMALE; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID DIET; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; APOLIPOPROTEINS; ARTERIOSCLEROSIS; BLOOD GLUCOSE; CATALYSIS; CHOLESTEROL; CROSSES, GENETIC; DIET, ATHEROGENIC; FEMALE; HUMANS; INSULIN; LIPASE; LIPOPROTEINS; LIVER; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 4444384650     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000135981.61827.9d     Document Type: Article

References (43)

1. Jackson RL. Lipoprotein lipase and hepatic lipase. In: Boyer PD, ed. The Enzymes. New York: Academic Press; 1983.
2. Brunzell JD, Deeb SS. Familial lipoprotein lipase deficiency, apoC-II deficiency, and hepatic lipase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B, eds. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill Medical Publishing Company; 2001.
3. Jansen H, van Berkel TJC, Hülsmann WC. Binding of liver lipase to parenchymal and non-parenchymal rat liver cells. Biochem Biophys Res Commun. 1978;85:148-152.
4. Sanan DA, Fan J, Bensadoun A, Taylor JM. Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver. J Lipid Res. 1997;38:1002-1013.
5. Dichek HL, Brecht W, Fan J, Ji Z-S, McCormick SPA, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high-density lipoproteins. J Biol Chem. 1998;273:1896-1903.
6. Ji Z-S, Lauer SJ, Fazio S, Bensadoun A, Taylor JM, Mahley RW. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J Biol Chem. 1994;269:13429-13436.
7. Diard P, Malewiak M-I, Lagrange D, Griglio S. Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes. Biochem J. 1994;299:889-894.
8. Ji Z-S, Dichek HL, Miranda RD, Mahley RW. Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high-density lipoproteins. J Biol Chem. 1997;272:31285-31292.
9. Dugi KA, Amar MJA, Haudenschild CC, Shamburek RD, Bensadoun A, Hoyt RF Jr, Fruchart-Najib J, Madj Z, Brewer HB Jr, Santamarina-Fojo S. In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL. Arterioscler Thromb Vasc Biol. 2000;20:793-800.
10. Dichek HL, Qian K, Agrawal N. The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient "apoB-48-only" and "apoB-100-only" mice. J Lipid Res. 2003;45:551-560.
11. Santamarina-Fojo S, Haudenschild C. Role of hepatic and lipoprotein lipase in lipoprotein metabolism and atherosclerosis: studies in transgenic and knockout animal models and somatic gene transfer. Int J Tissue React. 2000;22:39-47.
12. Jansen H, Verhoevenm AJM, Sijbrands EJG. Hepatic lipase: a pro-or anti-atherogenic protein? J Lipid Res. 2002;43:1352-1362.
13. Austin MA, King, M-C, Vranizan KM, Krauss, RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82:495-506.
14. Campos H, Dreon DM, Krauss RM. Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low-density lipoprotein subclasses. J Lipid Res. 1995;36:462-472.
15. 2 cholesterol. Arteriosclerosis. 1985;5:273-182.
16. Berg GA, Siseles N, Gonzalez AI, Ortiz OC, Tempone A, Wikinski RW. Higher values of hepatic lipase activity in postmenopause: relationship with atherogenic intermediate density and low-density lipoproteins. Menopause. 2001;8:51-57.
17. Rizzo M, Taylor JM, Barbagallo CM, Berneis K, Blanche PJ, Krauss RM. Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apo-B in transgenic rabbits. Arterioscler Thromb Vasc Biol. 2004;24:141-146.
18. Mezdour H, Jones R, Dengremont C, Castro G, Maeda N. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 1997;272:13570-13575.
19. Nong Z, Gonzalez-Navarro H, Amar M, Freeman L, Knapper C, Neufeld EB, Paigen BJ, Hoyt RF, Fruchart-Najib J, Santamarina-Fojo S. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. J Clin Invest. 2003;112:367-378.
20. Havel RJ, Kane JP. Structure and metabolism of plasma lipoproteins. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Kinzler KW, Vogelstein B, eds. The Metabolic and Molecular Bases of Inherited Disease. New York: McGraw-Hill; 2001.
21. Connelly PW. The role of hepatic lipase in lipoprotein metabolism. Clin Chim Acta. 1999;286:243-255.
22. 2. A study comparing liver perfusion to in vitro incubation with lipases. J Biol Chem. 1994;269:11572-11577.
23. Kuusi T, Kinnunen PKJ, Nikkilä EA. Hepatic endothelial lipase antiserum influences rat plasma low and high density lipoproteins in vivo. FEBS Lett. 1979;104:384-388.
24. Van Tol A, Van Gent T, Jansen H. Degradation of high-density lipoprotein by heparin-releasable liver lipase. Biochem Biophys Res Comm. 1980;92:101-108.
25. Busch SJ, Barnhart RL, Martin GA, Fitzgerald MC, Yates MT, Mao SJT, Thomas CE, Jackson RL. Human hepatic triglyceride lipase expression reduces high-density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J Biol Chem. 1994;269:16376-16382.
26. Braschi S, Couture N, Gambarotta A, Gauthier BR, Coffill CR, Sparks DL, Maeda N, Schultz JR. Hepatic lipase affects both HDL and ApoB-containing lipoprotein levels in the mouse. Biochim Biophys Acta. 1998;1392:276-290.
27. Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, Mahley RW. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res. 2001;42:201-210.
28. Homanics GE, de Silva HV, Osada J, Zhang SH, Wong H, Borensztajn J, Maeda N. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene. J Biol Chem. 1995;270:2974-2980.
29. Gaw A, Mancini FP, Ishibashi S. Rapid genotyping of low density lipoprotein receptor knockout mice using a polymerase chain reaction technique. Lab Anim. 1995;29:447-449.
30. Iverius P-H, Brunzell JD. Human adipose tissue lipoprotein lipase: Changes with feeding and relation to postheparin plasma enzyme. Am J Physiol. 1985;249:E107-E114.
31. McCormick SPA, Ng JK, Véniant M, Borén J, Pierotti V, Flynn LM, Grass DS, Connolly A, Young SG. Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene. J Biol Chem. 1996;271:11963-11970.
32. Véniant MM, Pierotti V, Newland D, Cham CM, Sanan DA, Walzem RL, Young SG. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest. 1997;100:180-188.
33. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 1997;46:3-10.
34. Rossmeisl M, Rim JS, Koza RA, Kozak LP. Variation in Type 2 Diabetes-related traits in mouse strains susceptible to diet-induced obesity. Diabetes. 2003;52:1958-1966.
35. Salmon DM, Flatt JP. Effect of dietary fat on the incidence of obesity among ad libitum fed mice. Intl J Obes. 1985;9:443-449.
36. Horobi RW. Conn's Biological Stains: A Handbook of Dyes, Stains, and Fluorochromes for Use in Biology and Medicine. Oxfordshire, UK: Bios Scientific Publisher; 2002.
37. Peterson J, Bengtsson-Olivecrona G, Olivecrona T. Mouse preheparin plasma contains high levels of hepatic lipase with low affinity for heparin. Biochim Biophys Acta. 1986;878:65-70.
38. Amar MJ, Dugi KA, Haudenschild CC, Shamburek RD, Foger B, Chase M, Bensadoun A, Hoyt RFJ, Brewer HBJ, Santamarina-Fojo S. Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice. J Lipid Res. 1998;39:2436-2442.
39. Willnow TE, Sheng Z, Ishibashi S, Herz J. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. 1994;264:1471-1474.
40. Shafi S, Brady SE, Bensadoun A, Havel RJ. Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver. J lipid Res. 1994;35:709-720.
41. Cooper AD. Hepatic uptake of chylomicron remnants. J Lipid Res. 1997;38:2173-2192.
42. Fuki IV, Meyer ME, Williams KW. Transmembrane and cytoplasmic domains of syndecan mediate a multi-step endocytic pathway involving detergent-insoluble membrane rafts. Biochem J. 2000;351:607-612.
43. Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids. 1993;28:599-605.