An assessment of genetic markers as predictors of bone turnover in healthy adults

Journal of Endocrinological Investigation

Volumn 24, Issue 4, 2001, Pages 236-245

  Sheehan, D ^a   Bennett, T ^a   Cashman, Kevin D ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Biochemical markers; Candidate genes; Osteoporosis; Polymorphisms

Indexed keywords

APOLIPOPROTEIN E; COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; ESTROGEN RECEPTOR; OSTEOCALCIN; PYRIDINOLINE; VITAMIN D RECEPTOR;

ADULT; AGED; ARTICLE; BONE TURNOVER; CAUCASIAN; DIET RESTRICTION; FREQUENCY ANALYSIS; GENETIC MARKER; GENOTYPE; HORMONE BLOOD LEVEL; HORMONE URINE LEVEL; HUMAN; IRELAND; NORMAL HUMAN; OSTEOPOROSIS; POPULATION GENETICS; RISK FACTOR; UNITED KINGDOM; URINE;

EID: 0035026913     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343853     Document Type: Article

References (37)

1. Riggs B.L., Melton L.J. III, O'Fallon W.M. Drug therapy for vertebral fractures in osteoporosis: evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy. Bone 1996, 18: S197-S201.
2. Hansen M.A., Overgaard K., Riis B.J., Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. B.M.J. 1991, 303: 961-964.
3. Parfitt A.M. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif. Tissue Int. 1984, 36: S123-S128.
4. Slemenda C.W., Christian J.C., Williams C.J., Norton J.A., Johnston C.C. Genetic determinants of bone mass in adult women: a reevaluation of the twin model and potential importance of gene interaction on heritability estimates. J. Bone Miner. Res. 1991, 6: 561 -567.
5. Arden N.K., Baker J., Hogg C., Baan K., Spector T.D. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J. Bone Miner. Res. 1996, 11: 530-534.
6. Kelly P.J., Hopper J.L., Macaskill G.T., Pocock N.A., Sambrook P.N., Eisman J.A. Genetic factors in bone turnover. J. Clin. Endocrinol. Metab. 1991, 72: 808-813.
7. Garnero P., Arden N.K., Griffiths G., Delmas P.D., Spector T.D. Genetic influence on bone turnover in postmenopausal twins. J. Clin. Endocrinol. Metab. 1996, 81: 140-146.
8. Morrison N.A., Qi J.C., Tokita A., Kelly P.J., Crofts L., Nguyen T.V., Sambrook P.N., Eisman J.A. Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367: 284-287.
9. Kobayashi S., Inoue S., Hosoi T., Ouchi Y., Shiraki M., Orimo H. Association of bone mineral density with polymorphism of the estrogen receptor gene. J. Bone Miner. Res. 1996, 11: 306-311.
10. Shiraki M., Shiraki Y., Aoki C., Hosoi T., Inoue S., Kaneki M., Ouchi Y. Association of bone mineral density and apolipoprotein E phenotype. J. Bone Miner. Res. 1997, 12: 1438-1445.
11. Grant S.F., Reid D.M., Blake G., Herd R., Fogelman I., Ralston S.H. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat. Genet. 1996, 14: 203-205.
12. Eisman J.A. Vitamin D receptor gene alleles and osteoporosis: an affirmative view. J. Bone Miner. Res. 1995, 10: 1289-1293.
13. Peacock M. Vitamin D receptor alleles and osteoporosis: a contrasting view. J. Bone Miner. Res. 1995, 10: 1294-1297.
14. Cooper G.S., Umbach D.M. Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J. Bone Miner. Res. 1996, 11: 1841-1849.
15. Riggs B.L., Nguyen T.V., Melton L.J. III, Morrison N.A., O'Fallon W.M., Kelly P.J., Egan K.S., Sambrook P.N., Muhs J.M., Eisman J.A. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J. Bone Miner. Res. 1995, 10: 991-996.
16. Gross C., Eccleshall T.R., Malloy P.J., Villa M.L., Marcus R., Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J. Bone Miner. Res. 1996, 11: 1850-1855.
17. Colwell R., Russell R.G.G., Eastell R. Factors affecting the assay of urinary 3-hydroxypyridinium crosslinks of collagen as markers of bone resorption. Eur. J. Clin. Invest. 1993, 23: 341-349.
18. Kelly P.J., Pocock N.A., Sambrook P.N., Eisman J.A. Age and menopause-related changes in indices of bone turnover. J. Clin. Endocrinol. Metab. 1989, 69: 1160-1165.
19. Eccleshall T.R., Garnero P., Gross C., Delmas P.D., Feldman D. Lack of correlation between start codon polymorphism of the vitamin D receptor gene and bone mineral density in premenopausal French women: the OFELY Study. J. Bone Miner. Res. 1998, 13: 31-35.
20. Cauley J.A., Zmuda J.M., Yaffe K., Kuller L.H., Ferrell R.E., Wisniewski S.R., Cumings S.R. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk - The study of osteoporotic fractures. J. Bone Miner. Res. 1999, 14: 1175-1181.
21. Willing M., Sowers M., Aron D., Clark M.K., Burns T., Bunten C., Crutchfield M., D'Agostino D., Jannausch M. Bone mineral density and its changes in white women: Estrogen and vitamin D receptor genotypes and their interaction. J. Bone Miner. Res. 1998, 13: 695-705.
22. Mahonen A., Turunen A.M., Kroger H., Maenpaa P.M. Estrogen receptor gene polymorphism is associated with bone mineral density in perimenopausal Finnish women. J. Bone Miner. Res. 1997, 12: S614.
23. Ongphiphadhanakul B., Rajatanavin R., Chanprasertyothin S., Piaseu N., Chailurkit L., Sirisriro R., Komindr S. Estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women but not in postmenopausal women. J. Endocrinol. Investig. 1998, 21: 487-493.
24. Cashman K., Flynn A. Optimal nutrition - calcium, magnesium and phosphorus. Proc. Nutr. Soc. 1999, 58: 477-487.
25. Uitterlinden A.G., Burger H., Huang Q., Yue F., McGuigan F., Grant S.F., Hofman A., Van Leeuwen J., Pols H.A., Ralston S.H. Relation of alleles of the collagen type I α1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N. Engl. J. Med. 1998, 338: 1016-1021.
26. Wood R.J., Fleet J.C. The genetics of osteoporosis: vitamin D receptor polymorphisms. Ann. Rev. Nutr. 1998, 18: 233-258.
27. Ralston S.H. Genetic markers of bone metabolism and bone disease. Scand. J. Clin. Lab. Invest. Suppl. 1997, 227: 114-121.
28. Ferrari S., Rizzoli R., Bonjour J.P. Genetic aspects of osteoporosis. Curr. Opin. Rheumatol. 1999, 11: 294-300.
29. Keen R.W., Woodford-Richens K.L., Grant S.F., Ralston S.H., Lanchbury J.S., Spector T.D. Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover. Arthritis Rheum. 1999, 42: 285-290.
30. Garnero P., Borel O., Grant S.F., Ralston S.H., Delmas P.D. Collagen Ialpha 1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: The OFELY Study. J. Bone Miner. Res. 1998, 13: 813-817.
31. Willing M.C., Torner J.C., Burns T.L., Segar E.T., Werner J.R. Determinants of bone mineral density in postmenopausal white lowans. J. Gerontol. 1997, 52A: M337-M342.
32. Morrison N.A., Yeoman R., Kelly P.J., Eisman J.A. Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor polymorphisms and circulating osteocalcin. Proc. Natl. Acad. Sci. USA 1992, 89: 6665-6669.
33. Sturzenbecker L., Scardaville B., Kratzeisen C., Katz M., Abarzua P., McLane J. Isolation and analysis of cDNA encoding a naturally-occurring truncated form of the human vitamin D receptor. In: Bouillon R., Norman A.W., Thomasset M. (Eds.), Vitamin D: A pluripotent steroid hormone: Structural studies, molecular endocrinology, and clinical applications. de Gruyter W., New York, 1994, p. 253.
34. Arai H., Miyamoto K., Taketani Y., Yamamoto H., Iemori Y., Morita K., Tonai T., Nishisho T., Mori S., Takeda E. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J. Bone Miner. Res. 1997, 12: 915-921.
35. Harris S.S., Eccleshall T.R., Gross C., Dawson-Hughes B., Feldman D. The vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in premenopausal American black and white women. J. Bone Miner. Res. 1997, 12: 1043-1048.
36. Ames S.K., Ellis K.J., Gunn S.K., Copeland K.C., Abrams S.A. Vitamin D receptor gene Fok I polymorphism predicts calcium absorption and bone mineral density in children. J. Bone Miner. Res. 1999, 14: 740-746.
37. Ferrari S., Rizzoli R., Manen D., Slosman D., Bonjour J.P. Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary calcium, and 3′-end region polymorphisms. J. Bone Miner. Res. 1998, 13: 925-930.