Activation of integrin αIIbβ3 in the glycoprotein lb-high population of a megakaryocytic cell line, CMK, by inside-out signaling

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 1, 2004, Pages 177-186

  Kashiwagi, Hirokazu ^a,b   Shiraga, M ^a,b   Honda, S ^a,b   Kosugi, S ^a,b   Kamae, T ^a,b   Kato, H ^a,b   Kurata, Y ^a,b   Tomiyama, Y ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

Author keywords

IIb 3; CMK cells; Inside out signaling

Indexed keywords

ALPHA2 INTEGRIN; ALPHA2B INTEGRIN; BETA3 INTEGRIN; CALCIMYCIN; CYTOCHALASIN D; FIBRINOGEN; GLYCOPROTEIN IB; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROSTAGLANDIN E1; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C THETA; RIBAVIRIN; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; FIBRINOGEN RECEPTOR; IONOPHORE; ISOENZYME; PROTEIN KINASE C; THROMBIN RECEPTOR;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL LINE; CELL POPULATION; CELL STRUCTURE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; LIGAND BINDING; MEGAKARYOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOLUBILITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; METABOLISM;

ALPROSTADIL; ANDROSTADIENES; CALCIMYCIN; CELL LINE; CYTOCHALASIN D; HUMANS; IONOPHORES; ISOENZYMES; MEGAKARYOCYTES; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN KINASE C; RIBAVIRIN; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE;

EID: 4444379805     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2003.00529.x     Document Type: Article

References (44)

1. Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood 1998; 91: 2645-57.
2. 3 deficiency. Int J Hematol 2000; 72: 448-54.
3. Rittenhouse SE. Phosphoinositide 3-kinase activation and platelet function. Blood 1996; 88: 4401-14.
4. 3. J Biol Chem 2001; 276: 42226-32.
5. 3 for fibrinogen. J Biol Chem 1999; 274: 25301-7.
6. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994; 124 1047-59.
7. 3 in a lymphocyte expression system. J Biol Chem 1995; 270: 18631-6.
8. 3 is different and cooperative with each other in a megakaryoblastic leukemia cell line, CMK. Blood 1998; 92: 1277-86.
9. Cichowski K, Orsini MJ, Brass LF. PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells. Biochim Biophys Acta 1999; 1450: 265-76.
10. 3 using a reconstituted mammalian cell expression model. J Cell Biol 1999; 147: 1085-96.
11. 3 activation both in platelets and a transfected Chinese hamster ovary cell system. J Biol Chem 2000; 275: 16779-87.
12. 3 and the platelet-activating factor: dissociation between adhesion and aggregation. Blood 2002; 99: 2819-27.
13. 3 signaling. J Cell Biol 1999; 147: 1419-30.
14. Faraday N, Rade JJ, Johns DC, Khetawat G, Noga SJ, DiPersio JF, Jin Y, Nichol JL, Haug JS, Bray PF. Ex vivo cultured megakaryocytes express functional glycoprotein IIb-IIIa receptors and are capable of adenovirus-mediated transgene expression. Blood 1999; 94: 4084-92.
15. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD, Shattil SJ. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci USA 2002; 99: 12819-24.
16. Sato T, Fuse A, Eguchi M, Hayashi Y, Ryo R, Adachi M, Kishimoto Y, Teramura M, Mizoguchi H, Shima Y, Komori I, Sunami S, Okimoto Y, Nakajima H. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryocytic leukaemia. Br J Haematol 1989; 72: 184-90.
17. Majumdar A, Kerby S, Mullikin B, Beckstead JH, Stenberg PE, Seidman MM. IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line. J Cell Physiol 1995; 165: 530-7.
18. Hagiwara S, Sato T, Itoh Y. Effects of recombinant human interleukin-3 on maturation of megakaryocytic cell line, CMK. Leuk Res 1997; 21: 153-62.
19. Matsumura I, Ishikawa J, Nakajima K, Oritani K, Tomiyama Y, Miyagawa J, Kato T, Miyazaki H, Matsuzawa Y, Kanakura Y. Thrombo-poietin-induced differentiation of a human megakaryocytic leukemia cell line, CMK, involves transcriptional activation of p21 (WAF1/Cip1) by STAT5. Mol Cell Biol 1997; 17: 2933-43.
20. Aoki T, Cox D, Senzaki K, Seki J, Tanaka A, Takasugi H, Motoyama Y. The anti-platelet and anti-thrombotic effects of FK633, a peptide-mimetic GPIIB/IIIA antagonist. Thromb Res 1996; 81: 439-50.
21. 3 integrin). Thromb Haemost 1996; 76: 1038-46.
22. 3 integrin cytoplasmic tail. J Cell Biol 1997; 137: 1433-43.
23. 3. Blood 1999; 93: 2559-68.
24. 3. Blood 1998; 91: 4206-15.
25. Salinovich O, Montelaro RC. Reversible staining and peptide mapping of proteins transferred to nitrocellulose after separation by sodium dodecylsulfate-polyacrylamide gel electrophoresis. Anal Biochem 1986; 156: 341-7.
26. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-14.
27. Abrams CS, Kazanietz MG. Platelet signaling: protein kinase C. In: Gresele P, Page C, Fuster V, Vermylem J, eds. Platelets in Thrombotic and Non-Thrombotic Disorders. Cambridge: Cambridge University Press, 2002: 272-80.
28. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 1993; 268 9194-7.
29. Szallasi Z, Smith CB, Pettit GR, Blumberg PM. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J Biol Chem 1994; 269: 2118-24.
30. Brodie C, Bogi K, Acs P, Lorenzo PS, Baskin L, Blumberg PM. Protein kinase C δ (PKC δ) inhibits the expression of glutamine synthetase in glial cells via the PKC δ regulatory domain and its tyrosine phosphorylation. J Biol Chem 1998; 273: 30713-8.
31. Sturk A, Schaap MC, ten Cate JW, Heymans HS, Schutgens RB, Przyrembel H, Borst P. Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis. J Clin Invest 1987; 79: 344-50.
32. Nagano T, Kishimoto Y, Kimura T, Yasunaga K, Adachi M, Ryo R, Sato T. Ultrastructural analysis of a human megakaryocytic leukemia cell line (CMK11-5) in response to platelet agonists. Int J Hematol 1993; 57: 73-80.
33. Adachi M, Ryo R, Sato T, Yamaguchi N. Platelet factor 4 gene expression in a human megakaryocytic leukemia cell line (CMK) and its differentiated subclone (CMK11-5). Exp Hematol 1991; 19: 923-7.
34. Ueda N, Yamashita R, Yamamoto S, Ishimura K. Induction of cyclooxygenase-1 in a human megakaryocytic cell line (CMK) differentiated by phorbol ester. Biochim Biophys Acta 1997; 1344: 103-10.
35. Suzuki T, Watanabe K, Kanaoka Y, Sato T, Hayaishi O. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochem Biophys Res Commun 1997; 241: 288-93.
36. Wright DG. A role for guanine ribonucleotides in the regulation of myeloid cell maturation. Blood 1987; 69: 334-7.
37. Kiguchi K, Collart FR, Henning-Chubb C, Huberman E. Cell differentiation and altered IMP dehydrogenase expression induced in human T-lymphoblastoid leukemia cells by mycophenolic acid and tiazofurin. Exp Cell Res 1990; 187: 47-53.
38. Takada M, Morii N, Kumagai S, Ryo R. The involvement of the rho gene product, a small molecular weight GTP-binding protein, in polyploidization of a human megakaryocytic cell line, CMK. Exp Hematol 1996; 24: 524-30.
39. 3 adhesion contacts under high shear. J Biol Chem 2002; 277: 14738-44.
40. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J 1997; 11: 649-69.
41. 3 functions as a molecular anchor for proteins that mediate integrin signaling. Blood 2002; 100: 122a (Abstract).
42. Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem 1992; 267: 18424-31.
43. Moussazadeh M, Haimovich B. Protein kinase C-δ activation and tyrosine phosphorylation in platelets. FEBS Lett 1998; 438 225-30.
44. Quinton TM, Kim S, Dangelmaier C, Dorsam RT, Jin J, Daniel JL, Kunapuli SP. Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem J 2002; 368: 535-43.