Heterogeneous competition of Kv1 channel toxins with kaliotoxin for binding in rat brain: Autoradiographic analysis

Neurochemistry International

Volumn 45, Issue 7, 2004, Pages 1039-1047

  Bessone, Richard ^a   Martin Eauclaire, Marie France ^a   Crest, Marcel ^a   Mourre, Christiane ^b  

^a CNRS   (France)

^b AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

dendrotoxin; DTX; IC50 value; kaliotoxin; KTX; Kv channel; mast cell degranulating peptide; MCDP; the concentration of unlabelled ligand required to displace 50 of the specific labelled binding; voltage dependent potassium channel

Indexed keywords

DENDROTOXIN; IODINE 125; KALIOTOXIN; MAST CELL DEGRANULATING PEPTIDE; VOLTAGE GATED POTASSIUM CHANNEL;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN REGION; COMPETITIVE BEHAVIOR; CONTROLLED STUDY; IC 50; LIGAND BINDING; MALE; NERVE CELL PLASTICITY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; VOLTAGE GATED POTASSIUM CHANNEL KV 1;

ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; MALE; POTASSIUM CHANNELS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SCORPION VENOMS;

MAMMALIA;

EID: 4444376928     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2004.05.006     Document Type: Article

References (36)

1. + channel, have interacting receptor sites. Biochem. Biophys. Res. Commun. 143:1987;383-389
2. + channel toxins, MCD peptide and dendrotoxin I. Brain Res. 495:1989;45-57
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254
4. Chung Y.H., Shin C.M., Kim M.J., Cha C.I. Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal ganglia. Brain Res. 875:2000;164-170
5. Chung Y.H., Shin C.M., Kim M.J., Lee B.K., Cha C.I. Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat cerebellum. Brain Res. 895:2001a;173-177
6. Chung Y.H., Shin C.M., Kim M.J., Lee B.K., Cha C.I. Age-related changes in the distribution of Kv1.1 and Kv1.2 channel subunits in the rat cerebellum. Brain Res. 897:2001b;193-198
7. Chung Y.H., Kim H.S., Shin C.M., Kim M.J., Cha C.I. Immunohistochemical study on the distribution of voltage-gated K(+) channels in rat brain following transient focal ischemia. Neurosci. Lett. 308:2001c;157-160
8. Coleman S.K., Newcombe J., Pryke J., Dolly J.O. Subunit composition of Kv1 channels in human CNS. J. Neurochem. 73:1999;849-858
9. + channels characterized from Androctonus mauretanicaus mauretanicus venom. J. Biol. Chem. 267:1992;1640-1647
10. Grissmer S., Nguyen A.N., Aiyar J., Hanson D.C., Mather R.J., Gurman G.A., Karmilowicz M.J., Auperin D.D., Chandy K.G. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol. 45:1994;1227-1234
11. Harvey A.L., Vatanpour H., Rowan E.G., Pinkasfeld S., Vita C., Menez A., Martin-Eauclaire M.-F. Structure-activity studies on scorpion toxins that block potassium channels. Toxicon. 33:1995;425-436
12. Harvey A.L. Recent studies on dendrotoxins and potassium ion channels. Gen. Pharmacol. 28:1997;7-12
13. Harvey A.L. Twenty years of dendrotoxins. Toxicon. 39:2001;15-26
14. Hoffman D.A., Magee J.C., Colbert C.M., Johnston D. K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387:1997;869-875
15. Hopkins W.F. Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 285:1998;1051-1060
16. Johnston D., Hoffman D.A., Colbert C.M., Magee J.C. Regulation of back-propagating action potentials in hippocampal neuronsm. Curr. Opin. Neurobiol. 9:1999;288-292
17. 2 from Androctonus australis venom. J. Biol. Chem. 269:1994;32835-32843
18. MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350:1991;232-235
19. McNamara N.M., Averill S., Wilkin G.P., Dolly J.O., Priestley J.V. Ultrastructural localization of a voltage-gated K+ channel alpha subunit (KV 1.2) in the rat cerebellum. Eur. J. Neurosci. 8:1996;688-699
20. + channel α and β subunits in rat hippocampal formation. J. Neurosci. 21:2001;5973-5983
21. Mourre C., Bidard J.N., Lazdunski M. High affinity receptors for the bee venom MCD peptide. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity. Brain Res. 446:1988;106-112
22. Mourre C., Chernova M.N., Martin-Eauclaire M.-F., Bessone R., Jacquet G., Gola M., Alper S.L., Crest M. Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 β-subunits. J. Pharmacol. Exp. Ther. 291:1999;943-952
23. Park K.H., Chung Y.H., Shin C., Kim M.J., Lee B.K., Cho S.S., Cha C.I. Immunohistochemical study on the distribution of the voltage-gated potassium channels in the gerbil hippocampus. Neurosci. Lett. 298:2001;29-32
24. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York, p. 258.
25. Pongs O. Molecular biology of voltage-dependent potassium channels. Physiol. Rev. 72:1992;S69-S88
26. + channel complexes. J. Neurosci. 17:1997;8246-8258
27. Romi R., Crest M., Gola M., Sampieri F., Jacquet G., Zerrouk H., Mansuelle P., Sorokine O., Van Dorsselaer A., Rochat H. Synthesis and characterization of kaliotoxin. Is the 26-32 sequence essential for potassium channel recognition? J. Biol. Chem. 268:1993;26302-26309
28. + channels in bovine brain. Biochemistry. 33:1994;1617-1623
29. + channel Kv1 subtypes in synaptic membranes from bovine brain. Biochemistry. 36:1997;8195-8201
30. + channel subunit in different neurons of rat brain. J. Neurosci. 14:1994;2408-2417
31. + currents in neurons. Neurosci. Res. 42:2002;7-14
32. Stühmer W., Ruppersberg J.P., Schröter K.H., Sakmann B., Stocker M., Giese K.P., Perschke A., Baumann A., Pongs O. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO J. 8:1989;3235-3244
33. Tricaud N., Marchot P., Martin-Eauclaire M.-F. On the kaliotoxin and dendrotoxin binding sites on rat brain synaptosomes. Toxicon. 38:2000;1749-1758
34. Tytgat J., Debont T., Carmeliet E., Daenens P. The α-dendrotoxin footprint on a mammalian potassium channel. J. Biol. Chem. 270:1995;24776-24781
35. Veh R.W., Lichtinghagen R., Sewing S., Wunder F., Grumbach I.M., Pongs O. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. Eur. J. Neurosci. 7:1995;2189-2205
36. + channel subtypes fractionated from rat brain using dendrotoxins. Eur. J. Biochem. 263:1999;230-237