4,4′-Disubstituted BINAPs for highly enantioselective Ru-catalyzed asymmetric hydrogenation of ketones

Organic Letters

Volumn 6, Issue 17, 2004, Pages 2937-2940

  Hu, Aiguo ^a   Ngo, Helen L ^a   Lin, Wenbin ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; PHOSPHINE DERIVATIVE; RUTHENIUM DERIVATIVE;

ARTICLE; ASYMMETRIC CATALYSIS; CATALYST; CHEMICAL REACTION; CHIRALITY; ENANTIOSELECTIVITY; HYDROGENATION; SYNTHESIS; X RAY ANALYSIS;

EID: 4444371631     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol048993j     Document Type: Article

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21. Since these precatalysts were synthesized on relatively small scales, we found it more convenient to purify them by column chromatography than recrystallization.
22. Purified precatalysts showed slightly higher ee's (typically 1-2% higher) than the crude precatalysts prepared in situ.
23. 3. R1 = 0.062, wR2 = 0.176, and GOF = 1.12. Flack parameter = -0.01(3).
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