Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism

American Journal of Psychiatry

Volumn 161, Issue 9, 2004, Pages 1581-1587

  Hettema, John M ^a,b   Prescott, Carol A ^a   Kendler, Kenneth S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CALCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; COVARIANCE; ENVIRONMENTAL FACTOR; FEMALE; GENDER; GENERALIZED ANXIETY DISORDER; HEREDITY; HUMAN; INTERVIEW; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL MODEL; NEUROSIS; PRIORITY JOURNAL; RISK; SEX DIFFERENCE;

ADULT; ANXIETY DISORDERS; DISEASES IN TWINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; NEUROTIC DISORDERS; PERSONALITY; PERSONALITY INVENTORY; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; SEX FACTORS; SOCIAL ENVIRONMENT; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; VARIATION (GENETICS);

EID: 4444362189     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.161.9.1581     Document Type: Article

References (30)

1. Freud S: The justification for detaching from neurasthenia a particular syndrome: the anxiety-neurosis (1894), in Collected Papers, vol 1. Edited by Jones E, translated by Riviere J. New York, Basic Books, 1959, pp 76-106
2. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 2nd ed. New York, New York State Psychiatric Institute, Biometrics Research, 1975
3. Breier A, Charney DS, Heninger GR: The diagnostic validity of anxiety disorders and their relationship to depressive illness. Am J Psychiatry 1985; 142:787-797
4. Akiskal HS: Toward a definition of generalized anxiety disorder as an anxious temperament type. Acta Psychiatr Scand Suppl 1998; 393:66-73
5. Brown TA, Barlow DH, Liebowitz MR: The empirical basis of generalized anxiety disorder. Am J Psychiatry 1994; 151:1272-1280
6. Costa PT Jr, McCrae RR: Influence of extraversion and neuroticism on subjective well-being: happy and unhappy people. J Pers Soc Psychol 1980; 38:668-678
7. Eysenck HJ, Eysenck MJ: Personality and Individual Differences: A Natural Science Approach. New York, Plenum, 1985
8. Gray JA, McNaughton N: The Neuropsychology of Anxiety, 2nd ed. Oxford, UK, Oxford University Press, 2000
9. Eysenck HJ, Eysenck SBG: Eysenck Personality Questionnaire Manual. London, Hodder and Stoughton, 1975
10. Hettema JM, Neale MC, Kendler KS: A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 2001; 158:1568-1578
11. Eaves LJ, Eysenck HJ, Martin NG: Genes, Culture and Personality: An Empirical Approach. Oxford, UK, Oxford University Press, 1989
12. Eaves LJ, Heath AC, Neale MC, Hewitt JK, Martin NG: Sex differences and non-additivity in the effects of genes on personality. Twin Res 1998; 1:131-137
13. Lake RI, Eaves LJ, Maes HH, Heath AC, Martin NG: Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents. Behav Genet 2000; 30: 223-233
14. Jardine R, Martin NG, Henderson AS: Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genet Epidemiol 1984; 1:89-107
15. Kendler KS, Prescott CA: A population-based twin study of lifetime major depression in men and women. Arch Gen Psychiatry 1999; 56:39-44
16. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ: A population-based twin study of major depression in women: the impact of varying definitions of illness. Arch Gen Psychiatry 1992; 49:257-266
17. Spence JE, Corey LA, Nance WE, Marazita ML, Kendler KS, Schieken RM: Molecular analysis of twin zygosity using VNTR DNA probes (abstract). Am J Hum Genet 1988; 43:A159
18. Spitzer RL, Williams JBW: Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1985
19. Neale MC, Eaves LJ, Kendler KS: The power of the classical twin study to resolve variation in threshold traits. Behav Genet 1994; 24:239-258
20. Hettema JM, Prescott CA, Kendler KS: A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 2001; 189:413-420
21. Neale MC, Cardon LR: Methodology for Genetic Studies of Twins and Families. Dordrecht, the Netherlands, Kluwer Academic, 1992
22. Neale MC, Boker SM, Xie G, Maes HH: Mx: Statistical Modeling, 5th ed. Richmond, Medical College of Virginia of Virginia Commonwealth University, Department of Psychiatry, 1999
23. Akaike H: Factor analysis and AIC. Psychometrika 1987; 52: 317-332
24. Fanous A, Gardner CO, Prescott CA, Cancro R, Kendler KS: Neuroticism, major depression and gender: a population-based twin study. Psychol Med 2002; 32:719-728
25. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ: Major depression and generalized anxiety disorder: same genes, (partly) different environments? Arch Gen Psychiatry 1992; 49:716-722
26. Kirk KM, Birley AJ, Statham DJ, Haddon B, Lake RI, Andrews JG, Martin NG: Anxiety and depression in twin and sib pairs extremely discordant and concordant for neuroticism: prodromus to a linkage study. Twin Res 2000; 3:299-309
27. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531
28. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale MC, Fiddy S, Mott R, Allison DB, Flint J: Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 2003; 72:879-890
29. Loehlin JC: Genes and Environment in Personality Development. Newbury Park, Calif, Sage Publications, 1992
30. Foley DL, Neale MC, Kendler KS: Reliability of a lifetime history of major depression: implications for heritability and comorbidity. Psychol Med 1998; 28:857-870