One-pot sequential Baylis-Hillman and Michael reactions

Tetrahedron Letters

Volumn 45, Issue 38, 2004, Pages 7141-7143

  Wang, Wengui ^a   Yu, Marvin ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Baylis Hillman; DBU; Michael; Multi component; One pot; Sequential

Indexed keywords

ACRYLIC ACID; ALDEHYDE; CARBON; ORGANIC COMPOUND;

ANALYTIC METHOD; ARTICLE; BAYLIS HILLMAN REACTION; CHEMICAL BOND; MICHAEL ADDITION; STRUCTURE ANALYSIS;

EID: 4444356873     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.07.122     Document Type: Article

References (22)

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21. Typical procedure: To a solution of benzaldehyde (1 g, 1.0 equiv) in THF (2 mL) were added DBU (1.0 equiv) and methyl acrylate (1.1 equiv) subsequently. The resulting solution was stirred at ambient temperature for 16 h. 2-Nitropropane (1.2 equiv) was slowly introduced into the reaction solution and stirred for another 3 h. The reaction mixture was concentrated to dryness and purified by silica gel chromatography to afford the desired product as a diastereomeric mixture
22. ++23)