The chemical development and scale-up of sampatrilat

Organic Process Research and Development

Volumn 7, Issue 3, 2003, Pages 244-253

  Dunn, Peter J ^a   Hughes, Michael L ^a   Searle, Patricia M ^a   Wood, Albert S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPROTEINASE INHIBITOR; METHACRYLIC ACID DERIVATIVE; SAMPATRILAT; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; BAYLIS HILLMAN REACTION; CHEMICAL REACTION; CHIRALITY; ENVIRONMENT; MICHAEL ADDITION; SCALE UP;

EID: 0038384719     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op020091f     Document Type: Article

References (17)

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17. The number of equivalents of PPACA required for complete reaction in these heterogeneous amide coupling reactions depends heavily on the efficiency of mixing in the reactor. For reactors with efficient stirring 2 equiv of PPACA can be used, and the third charge used in this preparation would be unnecessary.