Statistical evaluation of an acute dermal toxicity test using the dermal fixed dose procedure

Human and Experimental Toxicology

Volumn 23, Issue 8, 2004, Pages 405-412

  Stallard, Nigel ^a   Whitehead, Anne ^a   Indans, Ian ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b Department of Heath and Safety ^*  (United Kingdom)

Author keywords

Acute dermal toxicity testing; LD50 test; Median lethal dose; OECD Test Guideline 402

Indexed keywords

ARTICLE; DISEASE CLASSIFICATION; DOSE RESPONSE; FATALITY; FEMALE; LETHAL DOSE; MALE; MORTALITY; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; SKIN TOXICITY; STATISTICAL MODEL; TOXICITY TESTING;

ADMINISTRATION, CUTANEOUS; ANIMAL WELFARE; ANIMALS; ANIMALS, LABORATORY; ENDPOINT DETERMINATION; GUIDELINES; LETHAL DOSE 50; MODELS, STATISTICAL;

ANIMALIA;

EID: 4444338411     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht465oa     Document Type: Article

References (12)

1. OECD. Guidelines for the testing of chemical substances. No. 402 Acute dermal toxicity. Paris: OECD, 1987.
2. OECD. Harmonized integrated hazard classification system for human health and environmental effects of chemical substances. Paris: OECD, 1998.
3. OECD. Guidelines for the testing of chemical substances. No. 401 Acute oral toxicity. Paris: OECD, 1987.
4. OECD. Guidelines for the testing of chemical substances. No. 420 Acute oral toxicity - fixed dose method. Paris: OECD, 2001.
5. OECD. Guidelines for the testing of chemical substances. No. 423 Acute oral toxicity - acute toxic class method. Paris: OECD, 2001.
6. OECD. Guidelines for the testing of chemical substances. No. 425 Acute oral toxicity - up and down method. Paris: OECD, 2001.
7. Russell WMS, Burch RL. The principles of humane experimental technique. London: Methuen, 1959.
8. Stallard N, Whitehead A, Ridgway P. Statistical evaluation of the revised fixed dose procedure. Hum Exp Toxicol 2002; 21: 183-96.
9. Finney DJ. Probit analysis. Cambridge: Cambridge University Press, 1971.
10. Stallard N, Whitehead A, Indans I. Statistical evaluation of the fixed concentration procedure for acute inhalation toxicity assessment. Hum Exp Toxicol 2003; 22: 575-85.
11. Council Directive 67/548/EEC of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances. Off J Eur Communities 1967; 196: 1-5.
12. Council Directive 2001/59/EC of 6 August 2001 adapting for the 28th time Council Directive 67/548/EEC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances. Off J Eur Communities 2001; 225: 1-333.